Citation: Qing Feng JIANG, You Jun ZHOU, Jian Zhong YAO, Jia Guo LU, Ju ZHU, Chun Quan SHENG, Can Hui ZHENG, Bing YAO. Total Synthesis of Phakellistatin 13 by Solution Method[J]. Chinese Chemical Letters, ;2006, 17(8): 995-998. shu

Total Synthesis of Phakellistatin 13 by Solution Method

Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433

Received Date: 3 March 2006

Phakellistatin 13 is a good antitumor lead compound isolated from halobios. It was synthesized first time by solution method in combination of stepwise coupling and segment condensation. Final deprotection and cyclization were achieved according to our designed method, which was different from the reported process. The spectral data of synthetic product is consisted with literatureal data of natural product. Total synthesis of phakellistatin 13 is a significant achievement to further study of its derivatives and developing novel antitumor drugs.
- Phakellistatin 13,
- solution-phase synthesis,
- cyclopeptide
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