Citation: Ying Zhou, Yan Zhang. Design and Reform on Application of Photocatalysis to Experimental Teatching of Drug Synthesis Reactions[J]. Chemistry, ;2021, 84(6): 627-631, 626. shu

Design and Reform on Application of Photocatalysis to Experimental Teatching of Drug Synthesis Reactions

Ying Zhou ,
Yan Zhang ^,

School of Pharmaceutical Sciences, Jiangnan University, Wuxi, 214122

Corresponding author: Yan Zhang, zhangyanchem@163.com
Received Date: 14 December 2020
Accepted Date: 3 January 2021

Figures(3)

Photocatalysis induced by visible light is green, efficient and sustainable, which is very innovative in the synthesis of organic pharmaceutical intermediates and drug molecules. Application of the cutting-edge and innovative scientific research results into the undergraduate experimental teaching projects has become one of the focuses and trends of the reform of experimental teaching in universities. In this program, perylene diimide was used as a photocatalyst to obtain sulfoxide by selective sulfide under mild illumination conditions. Through this experiment, we provide an ideal platform for students to practice green, low energy consumption of organic chemistry, expand the students for today's synthetic technological frontier field of vision, mobilize the interest for the synthesis of new technology, new application, stimulated the enthusiasm of the challenge to the traditional synthetic method, cultivating the concept of scientific research innovation and independent thinking with problem-solving skills.
- Photocatalysis,
- Perylene diimide,
- Drug synthesis reactions
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
  Prier C K, Rankic D A, MacMillan D W. Chem. Rev., 2013, 113(7): 5322~5363.
7. [7]
  Yoon T P, Ischay M A, Du J. Nat. Chem., 2010, 2(7): 527~532.
8. [8]
  Lima C G S, de M. Lima T, Duarte M, et al. Catalysis, 2016, 6(3): 1389~1407.
9. [9]
  Artico M, Silvestri R, Massa S, et al. J. Med. Chem., 1996, 39(2): 522~530.
10. [10]
  Doherty G A, Kamenecka T, McCauley E, et al. Bioorg. Med. Chem. Lett., 2002, 12(5): 729~731.
11. [11]
  Hartz R A, Arvanitis A G, Arnold C, et al. Bioorg. Med. Chem. Lett., 2006, 16(4): 934~937.
12. [12]
  Bryliakov K P, Talsi E P. Curr. Org. Chem., 2012, 16(10): 1215~1242.
13. [13]
  Wasielewski M R. J. Org. Chem., 2006, 71(14): 5051~5066.
14. [14]
  Regar R, Mishra R, Mondal P K, et al. J. Org. Chem., 2018, 83(16): 9547~9552.
15. [15]
  Ghosh I, Ghosh T, Bardagi J I, et al. Science. 2014, 346(6210): 725~728.
16. [16]
  Zeng L, Liu T, He C, et al. J. Am. Chem. Soc., 2016, 138(12): 3958~3961.
17. [17]
  Gao Y, Xu H, Zhang S, et al. Org. Biomol. Chem., 2019, 17(30): 7144~7149.
18. [18]
19. [19]
20. [20]
21. [21]
  Tian S P, Bello I A, Peng J H, et al. J. Alloy. Compd., 2021, 854: 157223.
1. [1]
  Tongyan Yu , Pan Xu . Visible-Light Photocatalyzed Radical Rearrangement Reaction. University Chemistry, 2025, 40(7): 169-176. doi: 10.12461/PKU.DXHX202409070
2. [2]
  Yurong Tang , Yunren Shi , Yi Xu , Bo Qin , Yanqin Xu , Yunfei Cai . Innovative Experiment and Course Transformation Practice of Visible-Light-Mediated Photocatalytic Synthesis of Isoquinolinone. University Chemistry, 2024, 39(5): 296-306. doi: 10.3866/PKU.DXHX202311087
3. [3]
  Dan Liu . 可见光-有机小分子协同催化的不对称自由基反应研究进展. University Chemistry, 2025, 40(6): 118-128. doi: 10.12461/PKU.DXHX202408101
4. [4]
  Jiatong Hu , Qiyi Wang , Ruiwen Tang , Jiajing Feng . Photocatalytic Journey of Perylene Diimides in a Competitive Arena. University Chemistry, 2025, 40(5): 328-333. doi: 10.12461/PKU.DXHX202407015
5. [5]
  Jie Li , Huida Qian , Deyang Pan , Wenjing Wang , Daliang Zhu , Zhongxue Fang . Efficient Synthesis of Anethaldehyde Induced by Visible Light. University Chemistry, 2024, 39(4): 343-350. doi: 10.3866/PKU.DXHX202310076
6. [6]
  Zhen Yao , Bing Lin , Youping Tian , Tao Li , Wenhui Zhang , Xiongwei Liu , Wude Yang . Visible-Light-Mediated One-Pot Synthesis of Secondary Amines and Mechanistic Exploration. University Chemistry, 2024, 39(5): 201-208. doi: 10.3866/PKU.DXHX202311033
7. [7]
  Bo YANG , Gongxuan LÜ , Jiantai MA . Nickel phosphide modified phosphorus doped gallium oxide for visible light photocatalytic water splitting to hydrogen. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 736-750. doi: 10.11862/CJIC.20230346
8. [8]
  Xinzhe HUANG , Lihui XU , Yue YANG , Liming WANG , Zhangyong LIU , Zhongjian WANG . Preparation and visible light responsive photocatalytic properties of BiSbO₄/BiOBr. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 284-292. doi: 10.11862/CJIC.20240212
9. [9]
  Lirui Shen , Kun Liu , Ying Yang , Dongwan Li , Wengui Chang . Synthesis and Application of Decanedioic Acid-N-Hydroxysuccinimide Ester: Exploration of Teaching Reform in Comprehensive Applied Chemistry Experiment. University Chemistry, 2024, 39(8): 212-220. doi: 10.3866/PKU.DXHX202312035
10. [10]
  Qin Li , Huihui Zhang , Huajun Gu , Yuanyuan Cui , Ruihua Gao , Wei-Lin Dai . In situ Growth of Cd_0.5Zn_0.5S Nanorods on Ti₃C₂ MXene Nanosheet for Efficient Visible-Light-Driven Photocatalytic Hydrogen Evolution. Acta Physico-Chimica Sinica, 2025, 41(4): 2402016-0. doi: 10.3866/PKU.WHXB202402016
11. [11]
  Bing LIU , Huang ZHANG , Hongliang HAN , Changwen HU , Yinglei ZHANG . Visible light degradation of methylene blue from water by triangle Au@TiO₂ mesoporous catalyst. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 941-952. doi: 10.11862/CJIC.20230398
12. [12]
  Yikai Wang , Xiaolin Jiang , Haoming Song , Nan Wei , Yifan Wang , Xinjun Xu , Cuihong Li , Hao Lu , Yahui Liu , Zhishan Bo . Thickness-Insensitive, Cyano-Modified Perylene Diimide Derivative as a Cathode Interlayer Material for High-Efficiency Organic Solar Cells. Acta Physico-Chimica Sinica, 2025, 41(3): 2406007-0. doi: 10.3866/PKU.WHXB202406007
13. [13]
  Yuanqing Wang , Yusong Pan , Hongwu Zhu , Yanlei Xiang , Rong Han , Run Huang , Chao Du , Chengling Pan . Enhanced Catalytic Activity of Bi₂WO₆ for Organic Pollutants Degradation under the Synergism between Advanced Oxidative Processes and Visible Light Irradiation. Acta Physico-Chimica Sinica, 2024, 40(4): 2304050-0. doi: 10.3866/PKU.WHXB202304050
14. [14]
  Kexin Feng , Jie Zhang , Yujia Sun , Qiong Ai , Longchun Li . 乙酰二茂铁和二茂铁甲酰丙酮的合成、纯化及表征. University Chemistry, 2025, 40(8): 307-314. doi: 10.12461/PKU.DXHX202409045
15. [15]
  Yan Kong , Wei Wei , Lekai Xu , Chen Chen . Electrochemical Synthesis of Organonitrogen Compounds from N-integrated CO₂ Reduction Reaction. Acta Physico-Chimica Sinica, 2024, 40(8): 2307049-0. doi: 10.3866/PKU.WHXB202307049
16. [16]
  Yuanyuan Ping , Wangqing Kong . 光催化碳氢键官能团化合成1-苯基-1,2-乙二醇. University Chemistry, 2025, 40(6): 238-247. doi: 10.12461/PKU.DXHX202408092
17. [17]
  Lewang Yuan , Yaoyao Peng , Zong-Jie Guan , Yu Fang . Insights into the development of 2D covalent organic frameworks as photocatalysts in organic synthesis. Acta Physico-Chimica Sinica, 2025, 41(8): 100086-0. doi: 10.1016/j.actphy.2025.100086
18. [18]
  Tianlong Zhang , Rongling Zhang , Hongsheng Tang , Yan Li , Hua Li . Online Monitoring and Mechanistic Analysis of 3,5-diamino-1,2,4-triazole (DAT) Synthesis via Raman Spectroscopy: A Recommendation for a Comprehensive Instrumental Analysis Experiment. University Chemistry, 2024, 39(6): 303-311. doi: 10.3866/PKU.DXHX202312006
19. [19]
  Renxiao Liang , Zhe Zhong , Zhangling Jin , Lijuan Shi , Yixia Jia . A Palladium/Chiral Phosphoric Acid Relay Catalysis for the One-Pot Three-Step Synthesis of Chiral Tetrahydroquinoline. University Chemistry, 2024, 39(5): 209-217. doi: 10.3866/PKU.DXHX202311024
20. [20]
  Lili Jiang , Shaoyu Zheng , Xuejiao Liu , Xiaomin Xie . Copper-Catalyzed Oxidative Coupling Reactions for the Synthesis of Aryl Sulfones: A Fundamental and Exploratory Experiment for Undergraduate Teaching. University Chemistry, 2025, 40(7): 267-276. doi: 10.12461/PKU.DXHX202408004

Get Citation

PDF

XML

Metrics

PDF Downloads(64)
Abstract views(3602)
HTML views(656)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142