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Citation: Xue Liangmin, Wang Meng, Liu Junyi, Zhang Zhili. Cyclization Reaction of Pyridanopurine Derivatives as Novel Antifolate[J]. Chemistry, ;2018, 81(7): 653-656. shu

Cyclization Reaction of Pyridanopurine Derivatives as Novel Antifolate

1.
School of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Peking University, Beijing 100191
2.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191

Corresponding author: Zhang Zhili, lilybmu@bjmu.edu.cn
Received Date: 19 March 2018
Accepted Date: 7 May 2018

Figures(4)

7-Substituted 2-amine-8, 9-dihydro-7H-pyrido[1, 2, 3-gh]purin derivatives were synthesized by one-pot reaction with 6-substituted-2, 4-diaminopyrido[3, 2-d] pyrimidine, DMF and trichloroacetyl chloride at 25℃ for 2 h. The effects of different substrate, reaction substrate ratio, reaction time and temperature on reaction yield were investigated. The structures of the products were determined by NMR and HRMS, and the possible reaction mechanism was proposed. The reaction conditions are mild and easy to operate.
- DMF,
- Trichloroacetyl chloride,
- Cyclization reaction
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