Citation: Xiao Feng LI, Jian Yu LIU, Zhong Xian GUO, Yuan Zong LI, Ai Jin HUANG, Wen Bao CHANG. Water-Soluble Metalloporphyrins as Mimics of Heme-containing Enzymes[J]. Chinese Chemical Letters, ;2001, 12(11): 979-982. shu

Water-Soluble Metalloporphyrins as Mimics of Heme-containing Enzymes

The key laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871

Received Date: 26 March 2001

Fund Project: The authors are grateful for the financial supports from the Trans-Century Talent Foundation and the Key Laboratory of Bioorganic Chemistry & Molecular Engineering, Ministry of Education, China.

This letter compared catalase-, peroxidase-and cytochrome P450-1ike catalytic activities of 15 water-soluble metalloporphyrins produced from Fe, Mn and Co ions and 5 porphyrins. The metalloporphyrins with Fe and Mn as central ions show relatively high catalytic activities of catalase and peroxidase at pH 11.0. Only Mn-meso-tetrakis (4-N-methylpyridinium) porpho-phine of the 15 metalloporphyfins exhibits high cytochrome P450-1ike activity. Effects of imidazole on the catalytic reactions were also studied.
- Metalloporphyrin,
- biomimetic catalysis,
- peroxidase,
- catalase,
- cytochrome P450
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