Citation: Wang Ting, Cai Zhaosheng, Xu Qing. Progress in Preparation and Application of PEGylated Chitosans[J]. Chemistry, ;2020, 83(6): 536-545. shu

Progress in Preparation and Application of PEGylated Chitosans

Wang Ting ^1,2 ,
Cai Zhaosheng ^2,, ,
Xu Qing ^1,,

1.
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002
2.
School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, 224051

Corresponding author: Cai Zhaosheng, jsyc_czs@163.com Xu Qing, 6574394@qq.com
Received Date: 26 November 2019
Accepted Date: 2 January 2020

Figures(9)

Polyethylene glycol (PEG) is a non-toxic, lipophilic and hydrophilic compound which characterized with high biocompatibility and non-immunogenicity. Chitosan (CTS) can be transformed into PEGylated chitosan by introducing PEG into its sugar chain. It not only maintains the natural and excellent biodegradability of chitosan, but also has better water solubility and ability to bind organic compounds. The fields concerned with the application of CTS can be expanded through PEGylated modification. On basis of the relevant research traits in the past 20 years, the preparation of PEGylated chitosans and their application in the domains of drug loading and controlled release, tissue engineering, antibacterial materials, bioactive material delivery and environmental protection are summarized, and the future development trend is prospected.
- Chitosan,
- Polyethyleneglycol,
- Modification,
- Application
1. [1]
  Jin R, Moreira-Teixeira L P, Karperien M, et al. Biomaterials, 2009, 30(13): 2544~2551.
2. [2]
  Malhotra M, Tomaro-Duchesneau C, Prakash S. Biomaterials, 2013, 34(4): 1270~1280.
3. [3]
  Chen J, Huang L, Lai H, et al. Mol. Pharm., 2014, 11(7): 2213~2223
4. [4]
  Poon Y F, Cao Y, Liu Y, et al. ACS Appl. Mater. Interf., 2010, 2(7): 2012~2025.
5. [5]
  Casettari L, Vllasaliu D, Castagnino E, et al. Prog. Polym. Sci., 2012, 37(5): 659~685.
6. [6]
  Belabassi Y, Moreau J, Gheran V, et al. Biomacromolecules, 2017, 18(9): 2756~2766.
7. [7]
  Mao S, Shuai X, Unger F, et al. Biomaterials, 2005, 26(32): 6343~6356.
8. [8]
  Yang C, Gao S, Dagnæs-Hansen F, et al. ACS Appl. Mater. Interf., 2017, 9(14): 12203~12216.
9. [9]
  Li W, Zhan P, Clercq E D, et al. Prog. Polym. Sci., 2013, 38(3-4): 421~444.
10. [10]
  Waheed S, Ahmad A, Khan S M, et al. Desalination, 2014, 351: 59~69.
11. [11]
  Kolhe P, Kannan R M. Biomacromolecules, 2003, 4(1): 173~180.
12. [12]
  Mishra S K, Raveendran S, Ferreira J M F, et al. Langmuir, 2016, 32(40): 10305~10316.
13. [13]
  Gunbas I D, Sezer D U, Gülce-Iz S, et al. Ind. Eng. Chem. Res., 2012, 51(37): 11946~11954.
14. [14]
  Harris J M, Struck E C, Case M G, et al. J. Polym. Sci., 1984, 22(2): 341~352.
15. [15]
16. [16]
  Xie Y, Qiao H, Su Z, et al. Biomaterials, 2014, 35(27): 7978~7991.
17. [17]
  Shutava T G, Livanovich K S, Pankov V V. Colloid. Surf. A, 2018, 539: 69~79.
18. [18]
  Ma G, Zhang X, Han J, et al. Int. J. Biol. Macromol., 2009, 45(5): 499~503.
19. [19]
  Zhang X, Yang D, Nie J. Int. J. Biol. Macromol., 2008, 43(5): 456~462.
20. [20]
  El-Sherbiny I M, Smyth H D C. Carbohyd. Res., 2010, 345(14): 2004~2012.
21. [21]
  Bozuyuk U, Dogan N O, Kizilel S. ACS Appl. Mater. Interf., 2018, 10(40): 33945~33955.
22. [22]
  Hu Y, Jiang H, Xu C, et al. Carbohyd. Polym., 2005, 61(4): 472~479.
23. [23]
  Gorochovceva N, Makuška R. Eur. Polym. J., 2004, 40(4): 685~691.
24. [24]
25. [25]
  Yoksan R, Matsusaki M, Akashi M, et al. Colloid Polym. Sci., 2004, 282(4): 337~342.
26. [26]
  Fangkangwanwong J, Akashi M, Kida T, et al. Biopolymers, 2010, 82(6): 580~586.
27. [27]
  Poon Y F, Cao Y, Liu Y, et al. ACS Appl. Mater. Interf., 2010, 2(7): 2012~2025.
28. [28]
  Kiuchi H, Kai W, Inoue Y. J. Appl. Polym. Sci., 2008, 107(6): 3823~3830.
29. [29]
  Tanuma H, Saito T, Nishikawa K, et al. Carbohyd. Polym., 2010, 80(1): 260~265.
30. [30]
  Kulkarni A R, Hukkeri V I, Sung H W, et al. Macromol. Biosci., 2005, 5(10): 925~928.
31. [31]
  Yang X, Zhang Q, Wang Y, et al. Colloid. Surf. B, 2008, 61(2): 125~131.
32. [32]
  Pozzo A D, Vanini L, Fagnoni M, et al. Carbohyd. Polym., 2000, 42(2): 201~206.
33. [33]
  Dodi G, Hritcu D, Lisa G, et al. Chem. Eng. J., 2012, 203: 130~141.
34. [34]
  Hsiao M, Mu Q X, Stephen Z R, et al. ACS Macro Lett., 2015, 4(4), 403~407.
35. [35]
36. [36]
37. [37]
38. [38]
  Ganguly K, Aminabhavi T M, Kulkarni A R. Ind. Eng. Chem. Res., 2011, 50(21): 11797~11807.
39. [39]
40. [40]
  Liu N, Chen J, Zhang J, et al. Int. J. Biol. Macromol., 2018, 117: 553~558.
41. [41]
  Ma G, Yang D, Li Q, et al. Carbohyd. Polym., 2010, 79(3): 620~627.
42. [42]
43. [43]
44. [44]
  Doulabi A H, Mirzadeh H, Imani M, et al. Carbohyd. Polym., 2013, 92(1): 48~56.
45. [45]
  Shariatinia Z. Adv. Colloid Interf. Sci., 2019, 263: 131~194.
46. [46]
47. [47]
  F Zhou, X Jia, Q Yang, et al. Biomater. Sci., 2016, 4(5): 849~856.
48. [48]
  Park I K, Kim T H, Park Y H, et al. J. Control. Rel., 2001, 76(3): 349~362.
49. [49]
50. [50]
  Rahmi, Lelifajri, Nurfatimah R. Carbohyd. Polym., 2018, 199: 499~505.
1. [1]
  Dong-Bing Cheng , Junxin Duan , Haiyu Gao . Experimental Teaching Design on Chitosan Extraction and Preparation of Antibacterial Gel. University Chemistry, 2024, 39(2): 330-339. doi: 10.3866/PKU.DXHX202308053
2. [2]
  Xinhao Yan , Guoliang Hu , Ruixi Chen , Hongyu Liu , Qizhi Yao , Jiao Li , Lingling Li . Polyethylene Glycol-Ammonium Sulfate-Nitroso R Salt System for the Separation of Cobalt (II). University Chemistry, 2024, 39(6): 287-294. doi: 10.3866/PKU.DXHX202310073
3. [3]
  Yingtong Shi , Guotong Xu , Guizeng Liang , Di Lan , Siyuan Zhang , Yanru Wang , Daohao Li , Guanglei Wu . PEG-VN改性PP隔膜用于高稳定性高效率锂硫电池. Acta Physico-Chimica Sinica, 2025, 41(7): 100082-0. doi: 10.1016/j.actphy.2025.100082
4. [4]
  Xiaosong PU , Hangkai WU , Taohong LI , Huijuan LI , Shouqing LIU , Yuanbo HUANG , Xuemei LI . Adsorption performance and removal mechanism of Cd(Ⅱ) in water by magnesium modified carbon foam. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1537-1548. doi: 10.11862/CJIC.20240030
5. [5]
  Xuejiao Wang , Suiying Dong , Kezhen Qi , Vadim Popkov , Xianglin Xiang . Photocatalytic CO₂ Reduction by Modified g-C₃N₄. Acta Physico-Chimica Sinica, 2024, 40(12): 2408005-0. doi: 10.3866/PKU.WHXB202408005
6. [6]
  Tiantian Zheng , Huiyi Wang , Huimin Li , Xuanhe Liu , Hong Shang . Anti-Counterfeiting National Salvation Chronicle of 006. University Chemistry, 2024, 39(9): 254-258. doi: 10.3866/PKU.DXHX202307032
7. [7]
  Wenli FENG , Lu ZHAO , Yunfeng BAI , Feng FENG . Research progress on ultralong room temperature phosphorescent carbon dots. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 833-846. doi: 10.11862/CJIC.20240308
8. [8]
  Yuanyin Cui , Jinfeng Zhang , Hailiang Chu , Lixian Sun , Kai Dai . Rational Design of Bismuth Based Photocatalysts for Solar Energy Conversion. Acta Physico-Chimica Sinica, 2024, 40(12): 2405016-0. doi: 10.3866/PKU.WHXB202405016
9. [9]
  Miaomiao He , Zhiqing Ge , Qiang Zhou , Jiaqing He , Hong Gong , Lingling Li , Pingping Zhu , Wei Shao . Exploring the Fascinating Realm of Quantum Dots. University Chemistry, 2024, 39(6): 231-237. doi: 10.3866/PKU.DXHX202310040
10. [10]
  Laiying Zhang , Yaxian Zhu . Exploring the Silver Family. University Chemistry, 2024, 39(9): 1-4. doi: 10.12461/PKU.DXHX202409015
11. [11]
  Yuanyuan Ping , Wangqing Kong . 光催化碳氢键官能团化合成1-苯基-1,2-乙二醇. University Chemistry, 2025, 40(6): 238-247. doi: 10.12461/PKU.DXHX202408092
12. [12]
  Zhaoxuan ZHU , Lixin WANG , Xiaoning TANG , Long LI , Yan SHI , Jiaojing SHAO . Application of poly(vinyl alcohol) conductive hydrogel electrolytes in zinc ion batteries. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 893-902. doi: 10.11862/CJIC.20240368
13. [13]
  Nan Xiao , Fang Sun . 二芳基硫醚化合物的构建及应用. University Chemistry, 2025, 40(6): 360-363. doi: 10.12461/PKU.DXHX202407099
14. [14]
  Guilan He , Yaofeng Yuan . 手性二茂铁双膦配体Xyliphos的合成及应用. University Chemistry, 2025, 40(8): 130-137. doi: 10.12461/PKU.DXHX202409122
15. [15]
  Shasha SUN , Weichun HUANG , Mengke WANG . Research progress of interface regulation strategies and applications of two‑dimensional MXenes. Chinese Journal of Inorganic Chemistry, 2025, 41(8): 1465-1482. doi: 10.11862/CJIC.20240430
16. [16]
  Lirui Shen , Kun Liu , Ying Yang , Dongwan Li , Wengui Chang . Synthesis and Application of Decanedioic Acid-N-Hydroxysuccinimide Ester: Exploration of Teaching Reform in Comprehensive Applied Chemistry Experiment. University Chemistry, 2024, 39(8): 212-220. doi: 10.3866/PKU.DXHX202312035
17. [17]
  Huiwei Ding , Bo Peng , Zhihao Wang , Qiaofeng Han . Advances in Metal or Nonmetal Modification of Bismuth-Based Photocatalysts. Acta Physico-Chimica Sinica, 2024, 40(4): 2305048-0. doi: 10.3866/PKU.WHXB202305048
18. [18]
  Yan Xin , Yunnian Ge , Zezhong Li , Qiaobao Zhang , Huajun Tian . Research Progress on Modification Strategies of Organic Electrode Materials for Energy Storage Batteries. Acta Physico-Chimica Sinica, 2024, 40(2): 2303060-0. doi: 10.3866/PKU.WHXB202303060
19. [19]
  Chengqian Mao , Yanghan Chen , Haotong Bai , Junru Huang , Junpeng Zhuang . Photodimerization of Styrylpyridinium Salt and Its Application in Silk Screen Printing. University Chemistry, 2024, 39(5): 354-362. doi: 10.3866/PKU.DXHX202312014
20. [20]
  Xiaoyang Li , Xiaowei Huang , Yimeng Zhang , Huan Liu , Shao Jin , Junpeng Zhuang . Comprehensive Chemical Experiments on the Synthesis of 1,3-Dibromo-5,5-Dimethylhydantoin and Its Application as a Brominating Reagent. University Chemistry, 2025, 40(7): 286-293. doi: 10.12461/PKU.DXHX202408035

Get Citation

PDF

XML

Metrics

PDF Downloads(66)
Abstract views(4679)
HTML views(1777)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142