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Citation: Lu Shuiming, Chen Ruyu. Synthesis and Biological Activity of the Derivatives of 2,4,6-Trioxo-1,3,5,2-triazaphosphorine[J]. Chinese Journal of Applied Chemistry, ;1998, 15(5): 18-20. shu

Synthesis and Biological Activity of the Derivatives of 2,4,6-Trioxo-1,3,5,2-triazaphosphorine

Lu Shuiming ,
Chen Ruyu

Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071

Received Date: 18 February 1998
Revised Date: 17 June 1998

A series of the title 2,4,6-trioxo-1,3,5,2-triazaphosphorine derivatives have been synthesized by reaction of N,N-bis(2-chloroethyl)aminophosphoryldiisocyanate with ami nes. The structures of the products were confirmed by ¹H NMR, IR MS, ³¹P NMR and elemental analysis. The preliminary bioassay indicated that some of them had antitumor activity.
- triazaphosphorine,
- synthesis,
- biological activity
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