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Citation: Wan Lingzi, Bu Lehao, Liu Yaowei, Mao Yongjun. New Synthetic Method of Saflufenacil[J]. Chemistry, ;2019, 82(9): 826-830. shu

New Synthetic Method of Saflufenacil

College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620

Corresponding author: Mao Yongjun, yongjun.mao@hotmail.com
Received Date: 11 May 2019
Accepted Date: 21 June 2019

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The synthetic process of saflufenacil and its key intermediates is designed and completed, which has the potential for industrial manufacturing. The key intermediate N-methyl-N-isopropylaminosulfonamide is prepared by using chlorosulfonyl isocyanate, t-butanol, N-methyl-N-isopropylamine as the starting material. The overall yield of the three-step reaction is about 75%. Then, 2-chloro-4-fluorobenzoic acid was used as a raw material to prepare saflufenacil by nitration, chloridization, condensation, catalytic hydrogenation reduction, aminolysis and methylation reactions. The total yield of 8 steps is 48.6%, and the purity of the target product is 98.6%. The final products and the intermediates are characterized by NMR and MS.
- Herbicide,
- Saflufenacil,
- N-methyl-N-isopropylaminosulfonamide,
- Synthesis process
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