Citation: Hong Ping GUO, Cheng Zhi HUANG, Jian LING. Resonance Light Scattering Imaging Determination of Heparin[J]. Chinese Chemical Letters, ;2006, 17(1): 53-56. shu

Resonance Light Scattering Imaging Determination of Heparin

College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715

Received Date: 18 April 2005

Fund Project: Herein we are grateful to the supports from the National Natural Science Foundation of China (No. 20425517, No. 20275032), the Program for New Century Excellent Talents in University (NCET-04-0852) and Chun Hui Program (No: [2004] 7-24) directed under the Ministry of Education of PRC, and the Municipal Science and Technology Committee of Chongqing.

A laser-induced resonance light scattering (RLS) imaging method to determine heparin is described based on the high light scattering emission power of the aggregation species of heparin with α, β, γ, δtetra(4-trimethylaminoniumphenyl)prophyrin (TAPP) in solution. By imaging the light scattering signals of the aggregation species, we proposed the method to determine the heparin with a detection range of 0.02-0.6μg/mL and the detection limit (3σ) of 1.3 ng/mL.
- Heparin,
- α,β,γ,δ-tetra(4-trimethylaminonium phenyl)prophyrin (TAPP),
- resonance light scattering (RLS) imaging
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