Citation: Fan Yuxin, Yao Yaoyao, Chen Rui, Zhao Ping, Tang Lei, Wang Cong, Wang Ying. K₂CO₃-Promoted C-S bonds Construction via Direct Coupling of Benzofuran Units with Thiols at 3-Position[J]. Chemistry, ;2018, 81(7): 610-615, 609. shu

K₂CO₃-Promoted C-S bonds Construction via Direct Coupling of Benzofuran Units with Thiols at 3-Position

Fan Yuxin ¹ ,
Yao Yaoyao ¹ ,
Chen Rui ¹ ,
Zhao Ping ¹ ,
Tang Lei ^1,2 ,
Wang Cong ^1,, ,
Wang Ying ^1,2,,

1.
School of Pharmacy, Guizhou Medical University, Guiyang 550004
2.
Guizhou Provincial Engineering Technology Research Center for Chemical Drug R & D, Guizhou Medical University, Guiyang 550004

Corresponding author: Wang Cong, 619624244@qq.com Wang Ying, 280622267@qq.com
Received Date: 6 February 2018
Accepted Date: 7 May 2018

Figures(3)

Based on the previous work, this paper further investigated the reaction of 2-position branched benzofuran units with thiol to form C-S bond at the 3-position. The study found that K₂CO₃ can efficiently promoted the reaction with benzofuran units to produce 3-arylthiobenzofuran derivatives which the functional groups at the 2-position are aliphatic ketones with different chain lengths. All the products were characterized by NMR and HRMS. The reaction has the advantages of mild reaction conditions, wide range of substrate application, simple operation, high yield, environmental friendliness and so on. It can provide a potential synthetic pathway for the synthesis of natural products containing aromatic sulfur-substituted groups and complex drug molecules.
- K₂CO₃-promoted,
- Benzofuran,
- C-S bonds
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K2CO3-Promoted C-S bonds Construction via Direct Coupling of Benzofuran Units with Thiols at 3-Position

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K₂CO₃-Promoted C-S bonds Construction via Direct Coupling of Benzofuran Units with Thiols at 3-Position