Citation: Yuanbin Guo, Kun Li. Research Progress of Aptamers in Cancer Diagnosis[J]. Chemistry, ;2021, 84(1): 40-46. shu

Research Progress of Aptamers in Cancer Diagnosis

Yuanbin Guo ,
Kun Li ^,

School of Environmental and Chemical Engineering, Qinhuangdao, 066000

Corresponding author: Kun Li, likun@ysu.edu.cn
Received Date: 11 July 2020
Accepted Date: 2 September 2020

Figures(5)

Aptamers are short oligonucleotide molecules (ssDNA or RNA) screened from in vitro synthesized oligonucleotide libraries by exponential enrichment ligand phylogenetic technique (SELEX). Aptamers can bind to target molecules specifically by folding into specific spatial structures. Compared with antibodies, aptamers have a great deal of advantages, such as high affinity, easy modification, low cost, easy synthesis and low immunogenicity, which can be used for the research of cancer biomarkers, such as cells, proteins, tissues and growth factors. As a new method for cancer diagnosis, they have broad application prospects in molecular diagnosis. In this paper, the application of aptamers in the diagnosis of lung cancer, gastric cancer, colorectal cancer, breast cancer and prostate cancer in recent years is reviewed, and the role of aptamers as molecular probes from cell detection to serum detection is clarified.
- Aptamer,
- SELEX,
- Cancer,
- Diagnose
1. [1]
2. [2]
  Chen H, Gu Z, An H, et al. Sci. China Chem., 2018, 61(12): 1503~1552.
3. [3]
  Zhang G Q, Zhong L P, Yang N, et al. World J. Gastroenterol, 2019, 25(26): 3359~3369.
4. [4]
5. [5]
  Mayer G. Angew. Chem. Int. Ed., 2009, 48(15): 2672~2689.
6. [6]
  Qian R C, Cao Y, Zhao L J, et al. Angew. Chem. Int. Ed., 2017, 56(17): 4802~4805.
7. [7]
  Needham R J, Sanchez-Cano C, Zhang X, et al. Angew. Chem. Int. Ed., 2017, 56(4): 1017~1020.
8. [8]
  Tian F, Zhou J, Fu R, et al. Food Chem., 2020, 320: 126607.
9. [9]
10. [10]
  Zhao H, Xiang X, Chen M, et al. Toxins (Basel), 2019, 11(2).
11. [11]
  Ni X, Castanares M, Mukherjee A, et al. Curr. Med. Chem., 2011, 18(27): 4206~4214.
12. [12]
  Szostak A D E J W. Nature, 1990, 346: 818~822.
13. [13]
  Wang J, Gao T, Luo Y, et al. J. Mol. Evol., 2019, 87(2-3): 72~82.
14. [14]
  Lee K H, Jeong S, Yang E G, et al. Bioorg. Med. Chem., 2007, 15(24): 7545~7552.
15. [15]
  Mi J, Ray P, Liu J, et al. Mol. Ther. Nucl. Acids, 2016, 5: e315.
16. [16]
  Zhong W, Pu Y, Tan W, et al. Anal. Chem., 2019, 91(13): 8289~8297.
17. [17]
  Fraser L A, Kinghorn A B, Dirkzwager R M, et al. Biosens. Bioelectron., 2018, 100: 591~596.
18. [18]
  Bahreyni A, Ramezani M, Alibolandi M, et al. Anal. Biochem., 2019, 575: 1~9.
19. [19]
  Li W, Wang S, Zhou L, et al. Talanta, 2019, 199: 634~642.
20. [20]
  Ma Q, Qian W, Tao W, et al. Drug Des. Devel. Ther., 2019, 13: 4021~4033.
21. [21]
22. [22]
23. [23]
  Spiro S G, Silvestri G A. Am. J. Respir Crit. Care Med., 2005, 172(5): 523~529.
24. [24]
  Wang H, Zhang Y, Yang H, et al. Mol. Ther. Nucl. Acids, 2018, 10: 187~198.
25. [25]
  Wang H, Qin M, Liu R, et al. Sci. Rep., 2019, 9(1): 18836.
26. [26]
  Zamay G S, Kolovskaya O S, Zamay T N, et al. Mol. Ther., 2015, 23(9): 1486~1496.
27. [27]
  Zhou S, Gan Y, Kong L, et al. Anal. Chim. Acta, 2020, 1120: 43~49.
28. [28]
  Zhao Z, Xu L, Shi X, et al. Analyst, 2009, 134(9): 1808~1814.
29. [29]
  Tsai Y T, Liang C H, Yu J H, et al. Mol. Ther. Nucl. Acids, 2019, 18: 991~998.
30. [30]
  Zamay G S, Zamay T N, Kolovskii V A, et al. Sci. Rep., 2016, 6: 34350.
31. [31]
  Shi H, Cui W, He X, et al. PLoS One, 2013, 8(8): e70476.
32. [32]
  Jung Y J, Katilius E, Ostroff R M, et al. Clin. Lung Cancer, 2017, 18(2): e99~e107.
33. [33]
  Dendup T, Richter J M, Yamaoka Y, et al. World J. Gastroenterology, 2015, 21(38): 10883~10889.
34. [34]
  Alshaer W, Ababneh N, Hatmal M, et al. PLoS One, 2017, 12(12): e0189558.
35. [35]
  Qian R C, Cao Y, Long Y T. Anal. Chem., 2016, 88(17): 8640~8647.
36. [36]
  Ramezanpour M, Daei P, Tabarzad M, et al. Mol. Biol. Rep., 2019, 46(1): 207~215.
37. [37]
  Zheng Y, Zhao Y, Di Y, et al. RSC Adv., 2019, 9(2): 950~957.
38. [38]
  Colombo M, Raposo G, Thery C. Ann. Rev. Cell Dev. Biol., 2014, 30: 255~289.
39. [39]
  Huang R, He L, Li S, et al. Nanoscale, 2020, 12(4): 2445~2451.
40. [40]
  Yatabe J, Yatabe M S, Ishibashi K, et al. Diagn. Pathol., 2013, 8: 203~203.
41. [41]
  Lee S H, Park Y E, Lee J E, et al. Biosens. Bioelectron., 2020, 154: 112065.
42. [42]
  Maimaitiyiming Y, Yang C, Wang Y, et al. Biotechnol. Appl. Biochem., 2019, 66(3): 412~418.
43. [43]
  Zhao Y, Ma W, Zou S, et al. Talanta, 2019, 202: 152~158.
44. [44]
  Zhao Y, Xu J, Le V M, et al. Mol. Pharm., 2019, 16(11): 4696~4710.
45. [45]
  Li K, Qi L, Gao L, et al. RSC Adv., 2019, 9(66): 38867~38876.
46. [46]
  Zhou J, Duan L, Huang J, et al. Anal. Biochem., 2019, 577: 110~116.
47. [47]
  Bray F, Ferlay J, Soerjomataram I, et al. CA Cancer J. Clin., 2018, 68(6): 394~424.
48. [48]
  Chen W, Zheng R, Baade P D, et al. CA Cancer J. Clin., 2016, 66(2): 115~132.
49. [49]
  Wu L, Zhu L, Huang M, et al. Trends Anal. Chem., 2019, 117: 69~77.
50. [50]
  Li X, Zhang P, Dou L, et al. ACS Sensors, 2020, 5(8): 2359~2366.
51. [51]
  Beltran-Gastelum M, Esteban-Fernandez de Avila B, Gong H, et al. ChemPhysChem, 2019, 20(23): 3177~3180.
52. [52]
  Borghei Y S, Hosseini M, Ganjali M R, et al. Sens. Actuat. B, 2020, 315.
53. [53]
  Mohammadinejad A, Taghdisi S M, Es'haghi Z, et al. Eur. J. Pharm. Sci., 2019, 134: 60~68.
54. [54]
  Bezerra G, Córdula C, Campos D, et al. Anal. Bioanal. Chem., 2019, 411(25): 6667~6676.
55. [55]
  Bao J, Zhang W, Zhou W, et al. Talanta, 2020, 215: 120918.
56. [56]
  Zhu C, Li L, Wang Z, et al. Biosens. Bioelectron., 2020, 160.
57. [57]
  An Y, Li R, Zhang F, et al. Anal. Chem., 2020, 92(7): 5404~5410.
58. [58]
  Souza A G, Marangoni K, Fujimura P T, et al. Exp. Cell Res., 2016, 341(2): 147~156.
59. [59]
  Campos-Fernandez E, Barcelos L S, Souza A G, et al. ACS Omega, 2020, 5(7): 3533~3541.
60. [60]
  Ptacek J, Zhang D, Qiu L, et al. Nucl. Acids Res., 2020, DOI: 10.1093/nar/gkaa494.
61. [61]
  Kim M, Kim K, Lee J H. Microchem. J., 2020, 155: 104763.
62. [62]
  Ibau C, Md Arshad M K, Gopinath S C B, et al. Biosens. Bioelectron., 2019, 136: 118~127.
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