Citation: Yuanbin Guo, Kun Li. Research Progress of Aptamers in Cancer Diagnosis[J]. Chemistry, ;2021, 84(1): 40-46. shu

Research Progress of Aptamers in Cancer Diagnosis

Yuanbin Guo ,
Kun Li ^,

School of Environmental and Chemical Engineering, Qinhuangdao, 066000

Corresponding author: Kun Li, likun@ysu.edu.cn
Received Date: 11 July 2020
Accepted Date: 2 September 2020

Figures(5)

Aptamers are short oligonucleotide molecules (ssDNA or RNA) screened from in vitro synthesized oligonucleotide libraries by exponential enrichment ligand phylogenetic technique (SELEX). Aptamers can bind to target molecules specifically by folding into specific spatial structures. Compared with antibodies, aptamers have a great deal of advantages, such as high affinity, easy modification, low cost, easy synthesis and low immunogenicity, which can be used for the research of cancer biomarkers, such as cells, proteins, tissues and growth factors. As a new method for cancer diagnosis, they have broad application prospects in molecular diagnosis. In this paper, the application of aptamers in the diagnosis of lung cancer, gastric cancer, colorectal cancer, breast cancer and prostate cancer in recent years is reviewed, and the role of aptamers as molecular probes from cell detection to serum detection is clarified.
- Aptamer,
- SELEX,
- Cancer,
- Diagnose
1. [1]
2. [2]
  Chen H, Gu Z, An H, et al. Sci. China Chem., 2018, 61(12): 1503~1552.
3. [3]
  Zhang G Q, Zhong L P, Yang N, et al. World J. Gastroenterol, 2019, 25(26): 3359~3369.
4. [4]
5. [5]
  Mayer G. Angew. Chem. Int. Ed., 2009, 48(15): 2672~2689.
6. [6]
  Qian R C, Cao Y, Zhao L J, et al. Angew. Chem. Int. Ed., 2017, 56(17): 4802~4805.
7. [7]
  Needham R J, Sanchez-Cano C, Zhang X, et al. Angew. Chem. Int. Ed., 2017, 56(4): 1017~1020.
8. [8]
  Tian F, Zhou J, Fu R, et al. Food Chem., 2020, 320: 126607.
9. [9]
10. [10]
  Zhao H, Xiang X, Chen M, et al. Toxins (Basel), 2019, 11(2).
11. [11]
  Ni X, Castanares M, Mukherjee A, et al. Curr. Med. Chem., 2011, 18(27): 4206~4214.
12. [12]
  Szostak A D E J W. Nature, 1990, 346: 818~822.
13. [13]
  Wang J, Gao T, Luo Y, et al. J. Mol. Evol., 2019, 87(2-3): 72~82.
14. [14]
  Lee K H, Jeong S, Yang E G, et al. Bioorg. Med. Chem., 2007, 15(24): 7545~7552.
15. [15]
  Mi J, Ray P, Liu J, et al. Mol. Ther. Nucl. Acids, 2016, 5: e315.
16. [16]
  Zhong W, Pu Y, Tan W, et al. Anal. Chem., 2019, 91(13): 8289~8297.
17. [17]
  Fraser L A, Kinghorn A B, Dirkzwager R M, et al. Biosens. Bioelectron., 2018, 100: 591~596.
18. [18]
  Bahreyni A, Ramezani M, Alibolandi M, et al. Anal. Biochem., 2019, 575: 1~9.
19. [19]
  Li W, Wang S, Zhou L, et al. Talanta, 2019, 199: 634~642.
20. [20]
  Ma Q, Qian W, Tao W, et al. Drug Des. Devel. Ther., 2019, 13: 4021~4033.
21. [21]
22. [22]
23. [23]
  Spiro S G, Silvestri G A. Am. J. Respir Crit. Care Med., 2005, 172(5): 523~529.
24. [24]
  Wang H, Zhang Y, Yang H, et al. Mol. Ther. Nucl. Acids, 2018, 10: 187~198.
25. [25]
  Wang H, Qin M, Liu R, et al. Sci. Rep., 2019, 9(1): 18836.
26. [26]
  Zamay G S, Kolovskaya O S, Zamay T N, et al. Mol. Ther., 2015, 23(9): 1486~1496.
27. [27]
  Zhou S, Gan Y, Kong L, et al. Anal. Chim. Acta, 2020, 1120: 43~49.
28. [28]
  Zhao Z, Xu L, Shi X, et al. Analyst, 2009, 134(9): 1808~1814.
29. [29]
  Tsai Y T, Liang C H, Yu J H, et al. Mol. Ther. Nucl. Acids, 2019, 18: 991~998.
30. [30]
  Zamay G S, Zamay T N, Kolovskii V A, et al. Sci. Rep., 2016, 6: 34350.
31. [31]
  Shi H, Cui W, He X, et al. PLoS One, 2013, 8(8): e70476.
32. [32]
  Jung Y J, Katilius E, Ostroff R M, et al. Clin. Lung Cancer, 2017, 18(2): e99~e107.
33. [33]
  Dendup T, Richter J M, Yamaoka Y, et al. World J. Gastroenterology, 2015, 21(38): 10883~10889.
34. [34]
  Alshaer W, Ababneh N, Hatmal M, et al. PLoS One, 2017, 12(12): e0189558.
35. [35]
  Qian R C, Cao Y, Long Y T. Anal. Chem., 2016, 88(17): 8640~8647.
36. [36]
  Ramezanpour M, Daei P, Tabarzad M, et al. Mol. Biol. Rep., 2019, 46(1): 207~215.
37. [37]
  Zheng Y, Zhao Y, Di Y, et al. RSC Adv., 2019, 9(2): 950~957.
38. [38]
  Colombo M, Raposo G, Thery C. Ann. Rev. Cell Dev. Biol., 2014, 30: 255~289.
39. [39]
  Huang R, He L, Li S, et al. Nanoscale, 2020, 12(4): 2445~2451.
40. [40]
  Yatabe J, Yatabe M S, Ishibashi K, et al. Diagn. Pathol., 2013, 8: 203~203.
41. [41]
  Lee S H, Park Y E, Lee J E, et al. Biosens. Bioelectron., 2020, 154: 112065.
42. [42]
  Maimaitiyiming Y, Yang C, Wang Y, et al. Biotechnol. Appl. Biochem., 2019, 66(3): 412~418.
43. [43]
  Zhao Y, Ma W, Zou S, et al. Talanta, 2019, 202: 152~158.
44. [44]
  Zhao Y, Xu J, Le V M, et al. Mol. Pharm., 2019, 16(11): 4696~4710.
45. [45]
  Li K, Qi L, Gao L, et al. RSC Adv., 2019, 9(66): 38867~38876.
46. [46]
  Zhou J, Duan L, Huang J, et al. Anal. Biochem., 2019, 577: 110~116.
47. [47]
  Bray F, Ferlay J, Soerjomataram I, et al. CA Cancer J. Clin., 2018, 68(6): 394~424.
48. [48]
  Chen W, Zheng R, Baade P D, et al. CA Cancer J. Clin., 2016, 66(2): 115~132.
49. [49]
  Wu L, Zhu L, Huang M, et al. Trends Anal. Chem., 2019, 117: 69~77.
50. [50]
  Li X, Zhang P, Dou L, et al. ACS Sensors, 2020, 5(8): 2359~2366.
51. [51]
  Beltran-Gastelum M, Esteban-Fernandez de Avila B, Gong H, et al. ChemPhysChem, 2019, 20(23): 3177~3180.
52. [52]
  Borghei Y S, Hosseini M, Ganjali M R, et al. Sens. Actuat. B, 2020, 315.
53. [53]
  Mohammadinejad A, Taghdisi S M, Es'haghi Z, et al. Eur. J. Pharm. Sci., 2019, 134: 60~68.
54. [54]
  Bezerra G, Córdula C, Campos D, et al. Anal. Bioanal. Chem., 2019, 411(25): 6667~6676.
55. [55]
  Bao J, Zhang W, Zhou W, et al. Talanta, 2020, 215: 120918.
56. [56]
  Zhu C, Li L, Wang Z, et al. Biosens. Bioelectron., 2020, 160.
57. [57]
  An Y, Li R, Zhang F, et al. Anal. Chem., 2020, 92(7): 5404~5410.
58. [58]
  Souza A G, Marangoni K, Fujimura P T, et al. Exp. Cell Res., 2016, 341(2): 147~156.
59. [59]
  Campos-Fernandez E, Barcelos L S, Souza A G, et al. ACS Omega, 2020, 5(7): 3533~3541.
60. [60]
  Ptacek J, Zhang D, Qiu L, et al. Nucl. Acids Res., 2020, DOI: 10.1093/nar/gkaa494.
61. [61]
  Kim M, Kim K, Lee J H. Microchem. J., 2020, 155: 104763.
62. [62]
  Ibau C, Md Arshad M K, Gopinath S C B, et al. Biosens. Bioelectron., 2019, 136: 118~127.
1. [1]
  Qilong Fang , Yiqi Li , Jiangyihui Sheng , Quan Yuan , Jie Tan . Magical Pesticide Residue Detection Test Strips: Aptamer-based Lateral Flow Test Strips for Organophosphorus Pesticide Detection. University Chemistry, 2024, 39(5): 80-89. doi: 10.3866/PKU.DXHX202310004
2. [2]
  Qi Wang , Yicong Gao , Feng Lu , Quli Fan . Preparation and Performance Characterization of the Second Near-Infrared Phototheranostic Probe: A New Design and Teaching Practice of Polymer Chemistry Comprehensive Experiment. University Chemistry, 2024, 39(11): 342-349. doi: 10.12461/PKU.DXHX202404141
3. [3]
  Jiahui CHEN , Tingting ZHENG , Xiuyun ZHANG , Wei LÜ . Research progress of near-infrared absorption inorganic nanomaterials in photothermal and photodynamic therapy of tumors. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2396-2414. doi: 10.11862/CJIC.20240106
4. [4]
  Xin Lv , Hongxing Zhang , Kaibo Duan , Wenhui Dai , Zhihui Wen , Wei Guo , Junsheng Hao . Lighting the Way Against Cancer: Photodynamic Therapy. University Chemistry, 2024, 39(5): 70-79. doi: 10.3866/PKU.DXHX202309090
5. [5]
  Qilu DU , Li ZHAO , Peng NIE , Bo XU . Synthesis and characterization of osmium-germyl complexes stabilized by triphenyl ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1088-1094. doi: 10.11862/CJIC.20240006
6. [6]
  Zhongxin YU , Wei SONG , Yang LIU , Yuxue DING , Fanhao MENG , Shuju WANG , Lixin YOU . Fluorescence sensing on chlortetracycline of a Zn-coordination polymer based on mixed ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2415-2421. doi: 10.11862/CJIC.20240304
7. [7]
  Linjie ZHU , Xufeng LIU . Electrocatalytic hydrogen evolution performance of tetra-iron complexes with bridging diphosphine ligands. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 321-328. doi: 10.11862/CJIC.20240207
8. [8]
  Zijuan LI , Xuan LÜ , Jiaojiao CHEN , Haiyang ZHAO , Shuo SUN , Zhiwu ZHANG , Jianlong ZHANG , Yanling MA , Jie LI , Zixian FENG , Jiahui LIU . Synthesis of visual fluorescence emission CdSe nanocrystals based on ligand regulation. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 308-320. doi: 10.11862/CJIC.20240138
9. [9]
  Guilan He , Yaofeng Yuan . 手性二茂铁双膦配体Xyliphos的合成及应用. University Chemistry, 2025, 40(8): 130-137. doi: 10.12461/PKU.DXHX202409122
10. [10]
  Xiao SANG , Qi LIU , Jianping LANG . Synthesis, structure, and fluorescence properties of Zn(Ⅱ) coordination polymers containing tetra-alkenylpyridine ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2124-2132. doi: 10.11862/CJIC.20240158
11. [11]
  Hongjie SHEN , Haozhe MIAO , Yuhe YANG , Yinghua LI , Deguang HUANG , Xiaofeng ZHANG . Synthesis, crystal structure, and fluorescence properties of two Cu(Ⅰ) complexes based on pyridyl ligand. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 855-863. doi: 10.11862/CJIC.20250009
12. [12]
  Xiaoling LUO , Pintian ZOU , Xiaoyan WANG , Zheng LIU , Xiangfei KONG , Qun TANG , Sheng WANG . Synthesis, crystal structures, and properties of lanthanide metal-organic frameworks based on 2, 5-dibromoterephthalic acid ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1143-1150. doi: 10.11862/CJIC.20230271
13. [13]
  Yingchun ZHANG , Yiwei SHI , Ruijie YANG , Xin WANG , Zhiguo SONG , Min WANG . Dual ligands manganese complexes based on benzene sulfonic acid and 2, 2′-bipyridine: Structure and catalytic properties and mechanism in Mannich reaction. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1501-1510. doi: 10.11862/CJIC.20240078
14. [14]
  Youlin SI , Shuquan SUN , Junsong YANG , Zijun BIE , Yan CHEN , Li LUO . Synthesis and adsorption properties of Zn(Ⅱ) metal-organic framework based on 3, 3', 5, 5'-tetraimidazolyl biphenyl ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1755-1762. doi: 10.11862/CJIC.20240061
15. [15]
  Mengzhen JIANG , Qian WANG , Junfeng BAI . Research progress on low-cost ligand-based metal-organic frameworks for carbon dioxide capture from industrial flue gas. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 1-13. doi: 10.11862/CJIC.20240355
16. [16]
  Linjie ZHU , Xufeng LIU . Synthesis, characterization and electrocatalytic hydrogen evolution of two di-iron complexes containing a phosphine ligand with a pendant amine. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 939-947. doi: 10.11862/CJIC.20240416
17. [17]
  Lubing Qin , Fang Sun , Meiyin Li , Hao Fan , Likai Wang , Qing Tang , Chundong Wang , Zhenghua Tang . Atomically Precise (AgPd)₂₇ Nanoclusters for Nitrate Electroreduction to NH₃: Modulating the Metal Core by a Ligand Induced Strategy. Acta Physico-Chimica Sinica, 2025, 41(1): 100008-0. doi: 10.3866/PKU.WHXB202403008
18. [18]
  Xiaohang JIN , Qi LIU , Jianping LANG . Room‑temperature solid‑state synthesis, structure, and third‑order nonlinear optical properties of phosphine‑ligand‑protected silver thiolate clusters. Chinese Journal of Inorganic Chemistry, 2025, 41(8): 1505-1512. doi: 10.11862/CJIC.20250125
19. [19]
  Li Zhou , Dongyan Tang , Yunchen Du . Focusing on the Cultivation of Outstanding Talents: A “Five in One” Approach to Promoting the Construction of Chemical Experimental and Practical Teaching System. University Chemistry, 2024, 39(7): 121-128. doi: 10.12461/PKU.DXHX202405037
20. [20]
  Zhongbin Pan , Shijie Huang , Yunjie Luo , Hongzhen Xie . Design of a Comprehensive Experiment for Determining Permanganate Index (COD_Mn) in Drinking Water. University Chemistry, 2024, 39(7): 354-360. doi: 10.12461/PKU.DXHX202311040

Get Citation

PDF

XML

Metrics

PDF Downloads(30)
Abstract views(1940)
HTML views(584)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142