Citation: Zhao Wenpeng, Zhang Yangqian, Zhao Xueqin, Zhang Yimin. Optimization of Synthesis Process of Sulfobutyl Ether-β-Cyclodextrin by Response Surface Methodology[J]. Chemistry, ;2020, 83(12): 1149-1154. shu

Optimization of Synthesis Process of Sulfobutyl Ether-β-Cyclodextrin by Response Surface Methodology

School of Chemical Engineering and Technology, Key Laboratory for Green Chemical Technology of State Education Ministry, Tianjin University, Tianjin, 300350

Corresponding author: Zhang Yimin, zhangym@tju.edu.cn
Received Date: 5 May 2020
Accepted Date: 28 August 2020

Figures(5)

Using alkaline electrolyzed water as medium, SBE-β-CD with degree of substitution 3 was synthesized by water bath method and microwave method respectively with β-CD and 1, 4-butane sultone as raw materials. The effects of react temperature, react time and pH of alkaline electrolyzed water on the yield of product were investigated under two different conditions. Using product yield as response value, Box-Behnken response surface design was used to explore the influences of various variables and their interaction on product yield in microwave method, and the prediction model of regression equation was established. The results showed that the reaction time of microwave method was shortened by more than ten hours compared with the water bath method, and the product yield was increased by about 10%~20%. The optimum reaction conditions were obtained as follows:the react temperature was 77℃, the react time was 2.75 h, and pH of alkaline electrolyzed water was 12.7. Under the optimum reaction conditions, the product yield of 70.4% was obtained, which was close to the theoretical prediction value of the model.
- Sulfobutyl ether-β-cyclodextrin,
- β-cyclodextrin,
- 1, 4-butane sultone,
- Alkaline electrolyzed water,
- Response surface methodology
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