Citation: Liu Caiping, Bai Yang. Progress in the Application of Cyclodextrin-Based Supramolecular Polymer in Drug/Gene Delivery[J]. Chemistry, ;2018, 81(4): 326-331, 383. shu

Progress in the Application of Cyclodextrin-Based Supramolecular Polymer in Drug/Gene Delivery

Liu Caiping ,
Bai Yang ^,

College of Chemistry and Chemical Engineering, Shaanxi province Key Laboratory of Applied Chemistry, Shaanxi University of Science & Technology, Xi'an 710021

Corresponding author: Bai Yang, baiyang@sust.edu.cn
Received Date: 22 September 2017
Accepted Date: 31 January 2018

Figures(6)

Noncovalent interactions are utilized as the driving force to construct supramolecular polymers (SPs). Due to the dynamic and reversible natures, SPs have drawn increasing attention in the field of stimuli-responsive polymeric materials. As one of host molecules, cyclodextrin can form complexes with ferrocene, azobenzene, adamantine or benzene molecules which possess the proper size through host-guest inclusion interaction. The obtained SPs display fascinating property such as stimuli-responsive property, low cytotoxicity and good biocompatibility, which may further applied in the field of drug/gene delivery. Based on the biomedical application of cyclodextrin-based SPs, the main contents are summarized including three aspects as following, cyclodextrin-based SPs used in the drug controlled release, cyclodextrin-based SPs used in the gene transfection, cyclodextrin-based SPs used in the drug/gene co-delivery. Furthermore, new research trends are also expected on the progress of this kind of SPs.
- Cyclodextrin,
- Host-guest inclusion,
- Supramolecular polymers,
- Drug controlled release,
- Gene transfection
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Progress in the Application of Cyclodextrin-Based Supramolecular Polymer in Drug/Gene Delivery

南开大学师唯/华北电力大学（保定）刘景维：二维配位聚合物中有序的亲锂冠醚位点用于无枝晶锂沉积

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通讯作者: 陈斌, bchen63@163.com