Citation: Hu Jiadong, Wen Wen. Progress in the Stereoselective Construction of Chiral 4-Substituted Chroman Skeleton[J]. Chemistry, ;2020, 83(9): 799-804. shu

Progress in the Stereoselective Construction of Chiral 4-Substituted Chroman Skeleton

Hu Jiadong ^1,2,, ,
Wen Wen ¹

1.
School of Medicinal and Chemical Engineering, Yangling Vocational & Technical College, Yangling, 712100
2.
College of Chemistry & Pharmacy, Northwest A & F University, Yangling, 712100

Corresponding author: Hu Jiadong, hujiadong@aliyun.com
Received Date: 2 March 2020
Accepted Date: 8 April 2020

Figures(1)

Chiral 4-substituted chroman skeleton is widely found in numerous bioactive natural products and their analogues. The asymmetric construction strategy of this skeleton plays a crucial role in the research of new drugs. In order to provide a reference for the asymmetric synthesis of active natural products containing this skeleton, in this paper the stereoselective forge methods of chiral 4-substituted chroman from addition reaction, hydrogenation reaction, alkylation reaction, ene/propargylation reaction, desymmetrization reaction, carbonyl α-arylation reaction and rearrangement reaction are summarized.
- Chiral 4-substituted chroman skeleton,
- Stereoselectivity,
- Addition reaction,
- Hydrogenation reaction
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沈阳化工大学材料科学与工程学院沈阳 110142