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Citation: Shi Haijian, Wang Zhongyi, Shi Haoxin. Synthesis of 3,6-Diaryl-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazoles[J]. Chinese Journal of Applied Chemistry, ;1998, 15(3): 51-54. shu

Synthesis of 3,6-Diaryl-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazoles

1.
Department of Chemistry, Anhui Normal University, Wuhu 241000;
2.
Department of Chemistry, China University of Science and Technology, Hefei

Received Date: 21 October 1997
Revised Date: 16 March 1998

Ten title compounds have been prepared by reacting equal mole of 3-aryl 4-amino 5-mercapto-1,2,4-triazoles and aryl carboxylic acids in the presence of phosphorus oxychloride at 98 ℃ for 4~6 h. The structures of the compounds have been characterized by elemental analysis, IR, ¹H NMR and MS measurements. All the compounds were preliminary screened for antimicrobial activity against Staphylococcus aureus and Escherichia coli in 0.002% concentration. Some of the compounds exhibited a rather strong biological activity.
- diaryl-triazolo[3,4-b]-thiadiazole,
- synthesis,
- biological activity
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