Citation: Mingqin Chang, Qian Xi, Ming Ji, Wenyuan Huang, Tingyu Gao, Yang Li. Synthesis and In Vitro Antitumor Activity of Novel Quinoxaline-Based Isoindolin-1-Ones[J]. Chemistry, ;2021, 84(2): 154-161, 171. shu

Synthesis and In Vitro Antitumor Activity of Novel Quinoxaline-Based Isoindolin-1-Ones

Mingqin Chang ¹ ,
Qian Xi ¹ ,
Ming Ji ² ,
Wenyuan Huang ³ ,
Tingyu Gao ¹ ,
Yang Li ^1,,

1.
College of Chemistry and Chemical Engineering, Bohai University, Jinzhou, 121000
2.
Liaoyang Bureau of Quality and Technical Supervision, Liaoyang, 111099
3.
Fuxin Institute For Drug Control, Fuxin, 123000

Corresponding author: Yang Li, bhuzh@163.com
Received Date: 3 July 2020
Accepted Date: 17 September 2020

Figures(3)

In the present investigation, a simple and facile synthesis of a series of structurally novel and intriguing quinoxaline-based isoindolin-1-ones through the one-step reaction of ethyl 3-bromomethylquinoxaline-2-carboxylatewith with arylamines or aliphatic amines in refluxing ethanol medium has been described. The preliminary screening for their in vitro anti-tumor activity against A549 and HT29 using the MTT assay revealed that halo-substituted (F, Cl, Br, I) compounds 7h~7k showed promising inhibitory activity, among which fluro-substituted 7h possessed the best activity against the two cell lines with the IC₅₀ values of 1.50 and 3.77 μg/mL, respectively, which were higher than that of the reference drug cisplatin.
- Quinoxaline,
- Isoindolin-1-one,
- One-step reaction,
- Anti-tumor activity
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沈阳化工大学材料科学与工程学院沈阳 110142