Citation: Li Shangfeng, Ma Xiuguang. Research Progress in the Synthesis of Homocamptothecin[J]. Chemistry, ;2018, 81(3): 203-208. shu

Research Progress in the Synthesis of Homocamptothecin

Sundia MediTech Co., Ltd., Shanghai 201203

Received Date: 17 May 2017
Accepted Date: 29 August 2017

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To date, there have been two ways to synthesize homocamptothecin including semi-synthesis and total synthesis. The former is simple and concise, yet with few substituent groups. It only produces the racemic homocamptothecin. On the contrary, the latter can introduce various substituent groups on ring A and B. This protocol can bring the asymmetric synthesis into practice, though the route seems a little lengthy. All the study advance of homocamptothecin at home and abroad was reviewed. Each group's synthetic protocol was introduced in depth along with their research results. The outlook of homocamptothecin in the field of medicine was foreshown, with the indication of the future research direction.
- Homocamptothecin,
- Topoisomerase I
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沈阳化工大学材料科学与工程学院沈阳 110142