Citation: Tao HUANG, Kai Xun HUANG. Preparation and Analysis of Acylated Insulin with Dehydrocholic Acid[J]. Chinese Chemical Letters, ;2005, 16(6): 743-746. shu

Preparation and Analysis of Acylated Insulin with Dehydrocholic Acid

Tao HUANG ,
Kai Xun HUANG

Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074

Received Date: 15 June 2004

Fund Project: This research was supported by the National Natural Science Foundation of China (Project No. 20371018) and the Research Fund from the Department of Education of Hubei Province.

Insulin was chemically modified with dehydrocholic acid without the use of protecting agents and the main monoacylated insulin. ε-N^B29-Dehydrocholyl insulin was obtained selectively and analyzed by PAGE, HPLC and MALDI-TOF-MS.
- Insulin,
- dehydrocholic acid,
- dehydrocholyl insulin,
- chemical modification
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