Citation: Kun Liu, Yang Bai, Jing Yang, Huaitian Bu. Hyaluronic Acid-Based Drug Delivery Carriers and Their Applications[J]. Chemistry, ;2021, 84(3): 225-231. shu

Hyaluronic Acid-Based Drug Delivery Carriers and Their Applications

Shaanxi Key Laboratory of Chemical Additives for Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an, 710021

Corresponding author: Yang Bai, baiyang@sust.edu.cn Huaitian Bu, buhuaitian@hotmail.com
Received Date: 9 August 2020
Accepted Date: 20 October 2020

Figures(5)

Traditional nano-drug delivery carriers mainly achieve drug release through cellular endocytosis process. However, due to their passive targeting mechanism, the enrichment and therapeutic effect of nano carriers in tumor tissues will be reduced. In recent years, hyaluronic acid (HA) has been widely reported by researchers due to its excellent water-solubility, biocompatibility, biodegradability and active tumor targeting properties. Therefore, HA has been widely utilized in the construction of drug delivery carriers and has attracted much more attention in the field of targeted cancer therapy field. Based on the different therapeutic mechanism, HA-based nano carriers and their applications in chemotherapy, photothermal therapy, photodynamic therapy, and synergistic therapy fields are summarized in this paper. On this basis, the research trends are also expected based on the progress of HA-based nano-carriers.
- Hyaluronic acid,
- Drug controlled release,
- Active targeting ability,
- Tumor therapy
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