Citation: Qiao Sheng HU, Chang Ming HU. Michael Addition of Nitroalkanes to CF₃CCl₂COCH=CHPh:A Facile Route to Fluorine-containing γ-Nitro Ketones[J]. Chinese Chemical Letters, ;1997, 8(8): 665-668. shu

Michael Addition of Nitroalkanes to CF₃CCl₂COCH=CHPh:A Facile Route to Fluorine-containing γ-Nitro Ketones

Qiao Sheng HU ^a,b ,
Chang Ming HU ^a,b

a Laboratory of Organofluorine Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, 200032;
b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, 200032

Received Date: 17 December 1997

Fund Project: We thank the National Natural Science Foundation of China for financial support (No.29632003).

Nitroalkanes react smoothly with CF₃CCl₂COCH=CHPh via Michael addition in the presence of inorganic bases such as KF/Al₂O₃ or K₂CO₃,giving fluorine-containing γ-nitro ketones in good yields.
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