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Citation: Chen Wang, Hu Daihua, Feng Zili, Han Meng, Lin Mingyu. An Improved Synthesis of 1α-Hydroxydehydroepiandrosterone[J]. Chemistry, ;2018, 81(10): 934-938. shu

An Improved Synthesis of 1α-Hydroxydehydroepiandrosterone

Vitamin D Research Institute, Shaanxi University of Technology, Hanzhong 723001

Corresponding author: Chen Wang, chenwang0519@126.com
Received Date: 27 June 2018
Accepted Date: 6 July 2018

Figures(2)

1α-hydroxydehydroepiandrosterone was prepared from androsta-1, 4-diene-3, 17-dione through six steps including protection of carbonyl group, bromination, elimination, oxidation, incomplete hydrogenation and deprotection, with an overall yield of 29%. The method has the advantages of easily available raw materials, conventional reagents, mild reaction conditions, simple operation and lays a foundation for industrialized production of 1α-Hydroxydehydroepiandrosterone and the synthesis of vitamin D drugs.
- 1α-Hydroxydehydroepiandrosterone,
- Androsta-1, 4-diene-3, 17-dione,
- Incomplete hydrogenation
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