Citation: Zhong Keli, Xiu Ping, Guo Baofeng, Wang Daolin, Tang Lijun. Synthesis of a Thiazolo[3, 2-a]pyrimidine Derivative and Its Recognition Performance for Fe³⁺ in Aqueous Medium[J]. Chemistry, ;2017, 80(1): 84-88. shu

Synthesis of a Thiazolo[3, 2-a]pyrimidine Derivative and Its Recognition Performance for Fe³⁺ in Aqueous Medium

College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013

Corresponding author: Wang Daolin, wangdaolin@sina.com Tang Lijun, ljtang@bhu.edu.cn
Received Date: 8 July 2016
Accepted Date: 15 August 2016

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Thiazole[3, 2-a]pyrimidine derivatives have a variety of biological activities, but their applications are limited because of their poor solubilities. Thiazole[3, 2-a]pyrimidine derivative L has been successfully synthesized by nucleophilic substitution of 7-(3-aminobenzofuran-2-yl) thiazolo[3, 2-a]pyrimidin-5-one as aromatic ring matrix with triethylene glycol monomethyl ether. The structure of L was characterized by NMR and high resolution mass spectrum. Compound L can be used for highly selective recognition of Fe³⁺ with a fluorescence "ON-OFF" response in buffered aqueous solution (HEPES 1×10^-3 mol/L, pH=6.4). The fluorescent probe L displays a wide usable pH range from 3.4 to 6.4, non-interference from other metal ions and the low limit of detection.
- Thiazolo[3, 2-a]pyrimidine,
- Synthesis,
- Fe³⁺,
- Fluorescent probe,
- Recognition
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Synthesis of a Thiazolo[3, 2-a]pyrimidine Derivative and Its Recognition Performance for Fe3+ in Aqueous Medium

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通讯作者: 陈斌, bchen63@163.com

Synthesis of a Thiazolo[3, 2-a]pyrimidine Derivative and Its Recognition Performance for Fe³⁺ in Aqueous Medium