Citation: Nian Yujiao, Kong Weijun, Zhao Xue, Yang Shihai, Yang Meihua. Application Progress of Aptamers in Targeted Specific Detection[J]. Chemistry, ;2017, 80(9): 819-828. shu

Application Progress of Aptamers in Targeted Specific Detection

Nian Yujiao ^1,2 ,
Kong Weijun ¹ ,
Zhao Xue ³ ,
Yang Shihai ^2,, ,
Yang Meihua ^1,,

1.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193
2.
College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118
3.
Jilin Agricultural Science and Technology College, Jilin 132101

Corresponding author: Yang Shihai, jlyangs@163.com Yang Meihua, yangmeihua15@hotmail.com
Received Date: 18 February 2017
Accepted Date: 2 May 2017

Figures(4)

Aptamers are a kind of oligonucleotide sequences (DNA or RNA) obtained by SELEX technique in vitro, which can combine with the targets by folding into a certain space structure for specific adsorption. The function of aptamers is similar to that of antibodies, but they have incomparable advantages, such as a wide range of targets, good specificity and affinity, screening in vitro without animals, easy labeling and modification, good stability, no toxicity and easy to prepare. In recent years, aptamers have been widely used in the fields of analytical chemistry, biochemistry, food safety, clinical diagnosis and especially multi-components detection. In this paper, the applications of aptamers in rapid detection of metal ions, antibiotics, pesticide residues, mycotoxins, proteins, microorganisms and cells were reviewed, the possible limitations and the main problems were discussed, as well as the application trends were prospected in order to provide some supports and references to expand the application of aptamers and related research.
- Aptamers,
- Specific recognition,
- Sensitive and rapid detection
1. [1]
2. [2]
  J A Cruz-Aguado, G Penner. J. Agric. Food Chem., 2008, 56(22):10456~10461.
3. [3]
  C Tuerk, L Gold. Science, 1990, 249(4968):505~510.
4. [4]
  A D Ellington, J W Szostak. Nature, 1990, 346(6287):818~822.
5. [5]
  F Li, H Q Zhang, Z X Wang et al. Anal. Chem., 2014, 87(1):274~292.
6. [6]
  H Q Zhang, F Li, B Dever et al. Chem. Rev., 2012, 113(4):2812~2841.
7. [7]
8. [8]
  K H Leung, B Y He, C Yang et al. ACS Appl. Mater. Interf., 2015, 7(43):24046~24052.
9. [9]
  Z S Qian, X Y Shan, L J Chai et al. Biosens. Bioelectron., 2015, 68:225~231.
10. [10]
  S N Hashim, A Tsuchiya, N Kamiya et al. Chem. Lett., 2015, 44(12):1670~1672.
11. [11]
  A Yasmeen, F Du, Y Zhao et al. ACS Chem. Biol., 2016, 11(7):1945~1951.
12. [12]
  Y B Miao, N Gan, H X Ren et al. Talanta, 2016, 147:296~301.
13. [13]
  Y Wang, N Gan, T H Li et al. Anal. Methods, 2016, 8(15):3006~3013.
14. [14]
  J K Xue, J Liu, Wang C S et al. Anal. Methods, 2016, 8(9):1981~1988.
15. [15]
  Y N Zheng, Y L Yuan, Y Q Chai et al. Biosens. Bioelectron., 2015, 66:585~589.
16. [16]
  L Cui, J Wu, H X Ju. Biosens. Bioelectron., 2016, 79:861~865.
17. [17]
  S J Wu, H Zhang, Z Shi et al. Food Control, 2015, 50:597~604.
18. [18]
19. [19]
20. [20]
  H Kurt, M Yüce, B Hussain et al. Biosens. Bioelectron., 2016, 81:280~286.
21. [21]
  Y B Miao, H X Ren, N Gan et al. Anal. Chim. Acta, 2016, 929:49~55.
22. [22]
  T T Tang, J J Deng, M Zhang et al. Talanta, 2016, 146:55~61.
23. [23]
  H J Shi, G H Zhao, M C Liu et al. J. Hazard. Mater., 2013, 260:754~761.
24. [24]
  Y Tian, Y Wang, Z Sheng et al. Anal. Biochem., 2016, 513:87~92.
25. [25]
  W H Bai, C Zhu, J C Liu et al. Environ. Toxicol. Chem., 2015, 34(10):2244~2249
26. [26]
  B X Lin, Y Yu, R Y Li et al. Sens. Actuat. B, 2016, 229:100~109.
27. [27]
  X Liu, Y Li, J Liang et al. Talanta, 2016, 160:99~105.
28. [28]
  Y Y Qi, F R Xiu, M F Zheng et al. Biosens. Bioelectron., 2016, 83:243~249.
29. [29]
  P J Wang, Y Wan, A Ali et al. Sci. China:Chem., 2016, 59(2):237~242.
30. [30]
  R Bala, R K Sharma, N Wangoo. Anal. Bioanal. Chem., 2016, 408(1):333~338.
31. [31]
  L D Wu, P P Qi, X C Fu et al. J. Electroanal. Chem., 2016, 771:45~49.
32. [32]
  R Bala, M Kumar, K Bansal et al. Biosens. Bioelectron., 2016, 85:445~449.
33. [33]
  R Chauhan, J Singh, T Sachdev et al. Biosens. Bioelectron., 2016, 81:532~545.
34. [34]
  W L Zhou, W J Kong, X W Dou et al. J. Chromatogr. B, 2016, 1022:102~108.
35. [35]
  X H Yang, Y C Hu, W J Kong et al. J. Sep. Sci., 2014, 37(21):3052~3059.
36. [36]
  L Lv, C B Cui, C Y Liang et al. Food Control, 2016, 60:296~301.
37. [37]
  X F Chu, X W Dou, R Z Liang et al. Nanoscale, 2016, 8(7):4127~4133.
38. [38]
  L Chen, F Wen, M Li et al. Food Chem., 2017, 215:377~382.
39. [39]
  A Erdem, G Congur. Talanta, 2014, 128:428~433.
40. [40]
  S Scarano, E Dausse, F Crispo et al. Anal. Chim. Acta, 2015, 897:1~9.
41. [41]
  C C Chang, C Y Chen, T L Chuang et al. Biosens. Bioelectron., 2016, 78:200~205.
42. [42]
  Y T Tseng, C H Wang, C P Chang et al. Biosens. Bioelectron., 2016, 82:105~111.
43. [43]
  S F Yuan, N R Zhang, K L Singh et al. Antimicrob. Agents Chemother., 2015, 59(7):4082~4093.
44. [44]
  W K Li, X R Feng, X Yan et al. Nucleic Acid Ther., 2016,26(3):166~172.
45. [45]
46. [46]
  C L A Hamula, H Peng, Z Wang et al. J. Mol. Evol., 2015, 81(5~6):194~209.
47. [47]
  S M Yoo, D K Kim, S Y Lee. Talanta, 2015, 132:112~117.
48. [48]
  Q Y Wang, Y J Kang. Nanoscale Res. Lett., 2016, 11(1):1~9.
49. [49]
  D P Sun, J Lu, Z G Chen et al. Anal. Chim. Acta, 2015, 885:166~173.
50. [50]
  N Zhang, T Bing, L Y Shen et al. Angew. Chem. Int. Ed., 2016, 55(12):3914~3918.
51. [51]
  C L Esposito, S Catuogno, V de Franciscis. SiRNA Delivery Methods:Methods and Protocols, 2016, 1364:197~208.
52. [52]
  J F Callan, R C Mulrooney, S Kamila. J. Fluoresc., 2008, 18(6):1157~1161.
53. [53]
  Y L Wei, Y X Chen, H H Li et al. Biosens. Bioelectron., 2015, 63:311~316.
54. [54]
  Q Zhang, H B Qiu, F Q Tang et al. Chem. Lett., 2016, 45(3):289~290.
55. [55]
  H Z Qiu, Z E Huang, M Chen et al. Microchim. Acta, 2015, 182(15~16):2387~2393.
56. [56]
  F Chen, C Q Cai, X M Chen et al. Sci. Rep., 2016, 6:18814.
57. [57]
  X X He, Z X Li, X K Jia et al. Talanta, 2013, 111:105~110.
58. [58]
  Y Huo, L Qi, X J Lv et al. Biosens. Bioelectron., 2016, 78:315~320.
59. [59]
  Y F He, L F Liao, C H Xu et al. Microchim. Acta, 2015, 182(1~2):419~426.
60. [60]
61. [61]
  Y L Wei, Y X Chen, H H Li et al. Biosens. Bioelectron., 2015, 63:311~316.
62. [62]
  B Y Fang, M H Yao, C Y Wang et al. Colloid. Surf., B, 2016, 140:233~238.
63. [63]
  M Roushani, F Shahdost-Fard. Anal. Chim. Acta, 2015, 853:214~221.
64. [64]
  Y F Tang, F Long, C M Gu et al. Anal. Chim. Acta, 2016, 933:182~188.
65. [65]
  Z H Chen, Y Tan, K F Xu et al. Biosens. Bioelectron., 2016, 75:8~14.
66. [66]
  G Bozokalfa, H Akbulut, B Demir et al. Anal. Chem., 2016, 88(7):4161~4167.
67. [67]
  Z B Chen, M H Lu. Talanta, 2016, 160:444~448.
68. [68]
  S B Zhang, L P Wang, M L Liu et al. Anal. Methods, 2016, 8(18):3740~3746.
69. [69]
  Y L Zhang, Z Y Sun, L N Tang et al. Microchim. Acta, 2016, 183(10):2791~2797.
70. [70]
  F Haddache, A Le Goff, N Spinelli et al. Electrochim. Acta, 2016, 219:82~87.
71. [71]
  J M Wang, J Song, X Y Wang et al. Talanta, 2016, 161:437~442.
72. [72]
  A S Emrani, N M Danesh, M Ramezani et al. Biosens. Bioelectron., 2016, 79:288~293.
73. [73]
  D L Ma, M Wang, B He et al. ACS Appl. Mater. Interf., 2015, 7(34):19060~19067.
74. [74]
  M Roushani, F Shahdost-fard. Microchim. Acta, 2016, 183(1):185~193.
75. [75]
  F Beigloo, A Noori, M A Mehrgardi et al. J. Iran. Chem. Soc., 2016, 13(4):659~669.
76. [76]
  H Hasegawa, N Savory, K Abe et al. Molecules, 2016, 21(4):421.
77. [77]
  X L Tang, Y Hua, Q Guan et al. Eur. J. Clin. Microbiol. Infect. Dis., 2016, 35(4):587~595.
78. [78]
  G Mahlknecht, M Sela, Y Yarden. Gene Therapy of Solid Cancers:Methods Protoc., 2015:3~15.
79. [79]
  I C Elle, K K Karlsen, M G Terp et al. Mol. BioSyst., 2015, 11(5):1260~1270.
80. [80]
  E Ouellet, J H Foley, E M Conway et al. Biotechnol. Bioeng., 2015, 112(8):1506~1522.
81. [81]
82. [82]
83. [83]
  H P Dwivedi, R D Smiley, L A Jaykus. Appl. Microbiol. Biotechnol., 2010, 87:2323~2334.
84. [84]
  X J Xing, X G Liu, Y Zhou et al. RSC Adv., 2016, 6(14):11815~11821.
85. [85]
  D Q Fan, C T Wu, K Wang et al. Chem. Commun., 2016, 52(2):406~409.
86. [86]
  E Mondragón, L J Maher Ⅲ. Nucl. Acid Ther., 2016, 26(1):29~43.
87. [87]
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