Citation: Nian Yujiao, Kong Weijun, Zhao Xue, Yang Shihai, Yang Meihua. Application Progress of Aptamers in Targeted Specific Detection[J]. Chemistry, ;2017, 80(9): 819-828. shu

Application Progress of Aptamers in Targeted Specific Detection

Nian Yujiao ^1,2 ,
Kong Weijun ¹ ,
Zhao Xue ³ ,
Yang Shihai ^2,, ,
Yang Meihua ^1,,

1.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193
2.
College of Traditional Chinese Medicine, Jilin Agricultural University, Changchun 130118
3.
Jilin Agricultural Science and Technology College, Jilin 132101

Corresponding author: Yang Shihai, jlyangs@163.com Yang Meihua, yangmeihua15@hotmail.com
Received Date: 18 February 2017
Accepted Date: 2 May 2017

Figures(4)

Aptamers are a kind of oligonucleotide sequences (DNA or RNA) obtained by SELEX technique in vitro, which can combine with the targets by folding into a certain space structure for specific adsorption. The function of aptamers is similar to that of antibodies, but they have incomparable advantages, such as a wide range of targets, good specificity and affinity, screening in vitro without animals, easy labeling and modification, good stability, no toxicity and easy to prepare. In recent years, aptamers have been widely used in the fields of analytical chemistry, biochemistry, food safety, clinical diagnosis and especially multi-components detection. In this paper, the applications of aptamers in rapid detection of metal ions, antibiotics, pesticide residues, mycotoxins, proteins, microorganisms and cells were reviewed, the possible limitations and the main problems were discussed, as well as the application trends were prospected in order to provide some supports and references to expand the application of aptamers and related research.
- Aptamers,
- Specific recognition,
- Sensitive and rapid detection
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