Citation: Xi GONG, Xiao Xiao YANG, De Xin WANG. A New Route for the Synthesis of N-Substituted Diketopiperazine Derivatives[J]. Chinese Chemical Letters, ;2006, 17(4): 469-472. shu

A New Route for the Synthesis of N-Substituted Diketopiperazine Derivatives

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Received Date: 30 September 2005

Eight N-substituted diketopiperazines (DKPs) were synthesized by solid-phase protocols. The introduction of iminodiacetic acid (Ida) and followed another α-amino acid residue as the precursor of DKP framework made the present synthesis to bc very facile and efficient.
- Diketopiperazine,
- iminodiacetic acid,
- solid-phase synthesis
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