{"进展评述":[{"abstractInfo":"过去几十年里，抗肿瘤药物传输取得了巨大的进展，但是肿瘤的高效治疗依然是难啃的“硬骨头”。研究重点逐渐由载体肿瘤聚集向精确靶向、继而向肿瘤组织深处渗透性给药转移，特别是，如何克服种种障碍以实现其均匀地分布于整个肿瘤组织，达到有效的抗肿瘤药物浓度以更好地发挥疗效。本文从肿瘤组织渗透机理入手，探讨载体的粒径、Zeta电位、形状、结构与化学组成等因素对肿瘤组织渗透性的影响；介绍了多细胞球体模型、多层细胞培养与体内模型等肿瘤组织渗透性评价方法；并对载体在肿瘤组织渗透性方面的研究进行了展望。","abstractInfoCn":"过去几十年里，抗肿瘤药物传输取得了巨大的进展，但是肿瘤的高效治疗依然是难啃的“硬骨头”。研究重点逐渐由载体肿瘤聚集向精确靶向、继而向肿瘤组织深处渗透性给药转移，特别是，如何克服种种障碍以实现其均匀地分布于整个肿瘤组织，达到有效的抗肿瘤药物浓度以更好地发挥疗效。本文从肿瘤组织渗透机理入手，探讨载体的粒径、Zeta电位、形状、结构与化学组成等因素对肿瘤组织渗透性的影响；介绍了多细胞球体模型、多层细胞培养与体内模型等肿瘤组织渗透性评价方法；并对载体在肿瘤组织渗透性方面的研究进行了展望。","abstractInfoEn":"Over the last decades, remarkable progress has been made in the field of drug delivery in tumor.But, tumor therapy is still a tough nut to crack.However, in spite of significant advances to tumor targeting, an effective treatment strategy for malignant tumors still remains elusive.The research focus gradually shifted from the aggregation of carriers in the tumor to precise targeting and deep tumor penetration.How to overcome all obstacles to achieve its uniform distribution in the entire tumor tissue, to achieve an effective anti-tumor drug concentration are payed particular attention.In this paper, the mechanism of tumor tissue penetration were introduced, the effects of particles size, Zeta potential, particles shape, structure and chemical composition on tumor tissue penetration were discussed, and methods for assessing tumor tissue permeability were presented.The future research direction of this field was also prospected.","articleNo":"","authorCnList":["周国永"," 罗迎春"," 李和平"],"authorEnList":["Zhou Guoyong"," Luo Yingchun"," Li Heping"],"authorList":["周国永"," 罗迎春"," 李和平"],"authors":"周国永, 罗迎春, 李和平","authorsCn":"周国永, 罗迎春, 李和平","authorsEn":"Zhou Guoyong, Luo Yingchun, Li Heping","categoryName":"进展评述","categoryNameCn":"进展评述","categoryNameEn":"","citation":"周国永, 罗迎春, 李和平. 促进纳米载体肿瘤组织渗透性的研究进展. 化学通报, 2017, 80(10): 891-899.","citationCn":"周国永, 罗迎春, 李和平. 促进纳米载体肿瘤组织渗透性的研究进展. 化学通报, 2017, 80(10): 891-899.","citationEn":"周国永, 罗迎春, 李和平. Progress in Polymer Nano Carriers for Improving Deep Tumor Penetration. Chemistry, 2017, 80(10): 891-899.","doi":"","figContent":"hxtb-80-10-891-1.jpg$$hxtb-80-10-891-2.jpg$$hxtb-80-10-891-3.jpg$$hxtb-80-10-891-4.jpg$$hxtb-80-10-891-5.jpg$$hxtb-80-10-891-6.jpg$$hxtb-80-10-891-7.jpg$$hxtb-80-10-891-8.jpg$$hxtb-80-10-891-9.jpg","figList":["hxtb-80-10-891-1.jpg","hxtb-80-10-891-2.jpg","hxtb-80-10-891-3.jpg","hxtb-80-10-891-4.jpg","hxtb-80-10-891-5.jpg","hxtb-80-10-891-6.jpg","hxtb-80-10-891-7.jpg","hxtb-80-10-891-8.jpg","hxtb-80-10-891-9.jpg"],"firstFig":"hxtb-80-10-891-1.jpg","fpage":"891","highCitedState":"","htmlCount":1695,"htmlFile":"","id":"0c19d4e8-6243-4f94-8a83-e6b107a0f61f","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"肿瘤组织渗透, 抗癌药物, 纳米载体, 肿瘤治疗","keywordCn":"肿瘤组织渗透, 抗癌药物, 纳米载体, 肿瘤治疗","keywordCnList":["肿瘤组织渗透"," 抗癌药物"," 纳米载体"," 肿瘤治疗"],"keywordEn":"Tumor penetration, Anticancer drug, Nano-carriers, Tumor therapy","keywordEnList":["Tumor penetration"," Anticancer drug"," Nano-carriers"," Tumor therapy"],"keywordList":["肿瘤组织渗透"," 抗癌药物"," 纳米载体"," 肿瘤治疗"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"899","oldUrl":"","pdfDownCount":69,"pdfSize":3167.8,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"促进纳米载体肿瘤组织渗透性的研究进展","titleCn":"促进纳米载体肿瘤组织渗透性的研究进展","titleEn":"Progress in Polymer Nano Carriers for Improving Deep Tumor Penetration","viewCount":5014,"volume":"80","year":2017},{"abstractInfo":"手足口病是在东南亚，特别是在中国大规模频繁爆发的疾病，柯萨奇病毒A16型以及肠道病毒71型是引起感染的主要致病病原体，其中EV71感染不仅造成轻症病例，还能造成重症和死亡病例，也是在我国目前的主要致病原。目前我国已有EV71灭活疫苗上市，但疫苗本身存在一定程度风险且不能预防所有的手足口病。当前对于感染仅仅可以使用一些常用的广谱抗病毒药物进行支持性治疗。本文针对目前引起手足口病的EV71的小分子抑制剂的合成研究进展进行了综述，为治疗人手足口病的药物研发提供参考。","abstractInfoCn":"手足口病是在东南亚，特别是在中国大规模频繁爆发的疾病，柯萨奇病毒A16型以及肠道病毒71型是引起感染的主要致病病原体，其中EV71感染不仅造成轻症病例，还能造成重症和死亡病例，也是在我国目前的主要致病原。目前我国已有EV71灭活疫苗上市，但疫苗本身存在一定程度风险且不能预防所有的手足口病。当前对于感染仅仅可以使用一些常用的广谱抗病毒药物进行支持性治疗。本文针对目前引起手足口病的EV71的小分子抑制剂的合成研究进展进行了综述，为治疗人手足口病的药物研发提供参考。","abstractInfoEn":"Human Hand, Foot and Mouth Disease (HFMD) has always outbroken frequently and extensively in Southeast Asia, especially in China.Coxasckie virus A16 and Enterovirus 71 are the major pathogens to cause HFMD.EV71 is the main pathogen which caused HFMD in our country currently, it could lead to mild to severe clinical symptoms, and even to death.Approved inactivated vaccine for prevention of EV71 has been available recently, however it could not prevent all HFMD, and there is also a certain degree of risk when the vaccine is used.Only some commonly used broad-spectrum antiviral drugs could be applied for the treatment of HFMD in clinical at present.This review focus on the progress in drug syntheses of small molecule inhibitors of HFMD caused by EV71, and provides the reference for the development of effective therapeutic drugs for HFMD.","articleNo":"","authorCnList":["赵佩佩"," 贺万丽"," 赵杨杨"," 毛永红"," 汪颖"," 蔡岩"],"authorEnList":["Zhao Peipei"," He Wanli"," Zhao Yangyang"," Mao Yonghong"," Wang Ying"," Cai Yan"],"authorList":["赵佩佩"," 贺万丽"," 赵杨杨"," 毛永红"," 汪颖"," 蔡岩"],"authors":"赵佩佩, 贺万丽, 赵杨杨, 毛永红, 汪颖, 蔡岩","authorsCn":"赵佩佩, 贺万丽, 赵杨杨, 毛永红, 汪颖, 蔡岩","authorsEn":"Zhao Peipei, He Wanli, Zhao Yangyang, Mao Yonghong, Wang Ying, Cai Yan","categoryName":"进展评述","categoryNameCn":"进展评述","categoryNameEn":"","citation":"赵佩佩, 贺万丽, 赵杨杨, 毛永红, 汪颖, 蔡岩. 抗人手足口病药物的合成研究进展. 化学通报, 2017, 80(10): 900-907.","citationCn":"赵佩佩, 贺万丽, 赵杨杨, 毛永红, 汪颖, 蔡岩. 抗人手足口病药物的合成研究进展. 化学通报, 2017, 80(10): 900-907.","citationEn":"赵佩佩, 贺万丽, 赵杨杨, 毛永红, 汪颖, 蔡岩. Advances in the Synthesis of Drugs for Human Hand, Foot and Mouth Disease. Chemistry, 2017, 80(10): 900-907.","doi":"","figContent":"","figList":[],"firstFig":"","fpage":"900","highCitedState":"","htmlCount":0,"htmlFile":"","id":"fb5c5369-1d9b-48c4-b42b-f92d791784b6","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"人手足口病, 肠道病毒71型, 蛋白靶点, 药物合成,  ","keywordCn":"人手足口病, 肠道病毒71型, 蛋白靶点, 药物合成,  ","keywordCnList":["人手足口病"," 肠道病毒71型"," 蛋白靶点"," 药物合成","  "],"keywordEn":"Human Hand, Foot and Mouth Disease (HFMD), Enterovirus 71, Protein target, Drug synthesis","keywordEnList":["Human Hand"," Foot and Mouth Disease (HFMD)"," Enterovirus 71"," Protein target"," Drug synthesis"],"keywordList":["人手足口病"," 肠道病毒71型"," 蛋白靶点"," 药物合成","  "],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"907","oldUrl":"","pdfDownCount":4,"pdfSize":1077.63,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"抗人手足口病药物的合成研究进展","titleCn":"抗人手足口病药物的合成研究进展","titleEn":"Advances in the Synthesis of Drugs for Human Hand, Foot and Mouth Disease","viewCount":556,"volume":"80","year":2017},{"abstractInfo":"砜类化合物具有广谱的生物活性，广泛应用于化学、医药、农药、材料科学等领域。同时作为强吸电子基团，砜类化合物可以通过碱和亲电试剂反应延长碳链，因此该类化合物的合成方法引起了国内外研究人员的高度重视，本文结合国内外学者对这方面的相关研究，重点从硫醚氧化、磺酰氯的磺酰化和亚磺酸盐的偶联三个方面对近几年来砜类化合物合成方法进行了综述。","abstractInfoCn":"砜类化合物具有广谱的生物活性，广泛应用于化学、医药、农药、材料科学等领域。同时作为强吸电子基团，砜类化合物可以通过碱和亲电试剂反应延长碳链，因此该类化合物的合成方法引起了国内外研究人员的高度重视，本文结合国内外学者对这方面的相关研究，重点从硫醚氧化、磺酰氯的磺酰化和亚磺酸盐的偶联三个方面对近几年来砜类化合物合成方法进行了综述。","abstractInfoEn":"The broad spectrum of biological activity of sulfone compounds endows a wide applications in chemistry, medicine, agrochemistry and material science.Being an strong electron-withdrawing group, elongation of carbon chain could easily achieved <i>via<\/i> reaction of aliphatic sulfones with various electrophiles under basic condition.As a result, novel synthetic methodologies have continuous been developed especially during the past decades.This paper aimed at summarizing the synthetic methods of the sulfone compounds appeared in recent years, emphasizing the oxidation of sulfides, sulfonylation with sulfonyl chlorides and coupling of sulfinic acid salts.","articleNo":"","authorCnList":["肖彩琴"],"authorEnList":["Xiao Caiqin"],"authorList":["肖彩琴"],"authors":"肖彩琴","authorsCn":"肖彩琴","authorsEn":"Xiao Caiqin","categoryName":"进展评述","categoryNameCn":"进展评述","categoryNameEn":"","citation":"肖彩琴. 砜类化合物合成研究进展. 化学通报, 2017, 80(10): 908-917.","citationCn":"肖彩琴. 砜类化合物合成研究进展. 化学通报, 2017, 80(10): 908-917.","citationEn":"肖彩琴. Progress in the Syntheses of Sulfones. Chemistry, 2017, 80(10): 908-917.","doi":"","figContent":"hxtb-80-10-908-S1.jpg$$hxtb-80-10-908-S2.jpg$$hxtb-80-10-908-S3.jpg$$hxtb-80-10-908-S4.jpg$$hxtb-80-10-908-S5.jpg$$hxtb-80-10-908-S6.jpg$$hxtb-80-10-908-S7.jpg$$hxtb-80-10-908-S8.jpg$$hxtb-80-10-908-S9.jpg$$hxtb-80-10-908-S10.jpg$$hxtb-80-10-908-S11.jpg$$hxtb-80-10-908-S12.jpg","figList":["hxtb-80-10-908-S1.jpg","hxtb-80-10-908-S2.jpg","hxtb-80-10-908-S3.jpg","hxtb-80-10-908-S4.jpg","hxtb-80-10-908-S5.jpg","hxtb-80-10-908-S6.jpg","hxtb-80-10-908-S7.jpg","hxtb-80-10-908-S8.jpg","hxtb-80-10-908-S9.jpg","hxtb-80-10-908-S10.jpg","hxtb-80-10-908-S11.jpg","hxtb-80-10-908-S12.jpg"],"firstFig":"hxtb-80-10-908-S1.jpg","fpage":"908","highCitedState":"","htmlCount":3841,"htmlFile":"","id":"9f2a0857-3205-4f12-8eb2-e5aeb8846251","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"砜类化合物, 合成","keywordCn":"砜类化合物, 合成","keywordCnList":["砜类化合物"," 合成"],"keywordEn":"Sulfones, Synthesis","keywordEnList":["Sulfones"," Synthesis"],"keywordList":["砜类化合物"," 合成"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"917","oldUrl":"","pdfDownCount":227,"pdfSize":1280.83,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"砜类化合物合成研究进展","titleCn":"砜类化合物合成研究进展","titleEn":"Progress in the Syntheses of Sulfones","viewCount":8906,"volume":"80","year":2017},{"abstractInfo":"表面活性肽（Surfactin）是由枯草芽孢杆菌（<i>Bacillussubtilis<\/i>）发酵产生的一系列具有相似基本结构的环状脂肽。与合成的表面活性剂相比，Surfactin的优势在于，其是以碳氢化合物等可再生能源为原料、采用微生物发酵技术产生的纯天然产品，具有表面活性大、环境无污染、易生物降解、抑菌作用良好等优异特性，符合现代绿色化学发展理念，在多个领域应用广泛。本文详细介绍了Surfactin的基本结构、主要特性、生产工艺、纯化方式以及应用，并对Surfactin下一步的研究工作进行了展望，为今后关于Surfactin的进一步研究提供了便利。","abstractInfoCn":"表面活性肽（Surfactin）是由枯草芽孢杆菌（<i>Bacillus subtilis<\/i>）发酵产生的一系列具有相似基本结构的环状脂肽。与合成的表面活性剂相比，Surfactin的优势在于，其是以碳氢化合物等可再生能源为原料、采用微生物发酵技术产生的纯天然产品，具有表面活性大、环境无污染、易生物降解、抑菌作用良好等优异特性，符合现代绿色化学发展理念，在多个领域应用广泛。本文详细介绍了Surfactin的基本结构、主要特性、生产工艺、纯化方式以及应用，并对Surfactin下一步的研究工作进行了展望，为今后关于Surfactin的进一步研究提供了便利。","abstractInfoEn":"Surfactin belongs to biosurfactant.It is a series of cyclic lipopeptides with similar basic structures produced by fermentation of <i>Bacillus subtilis.<\/i> Compared with synthetic surfactant, surfactin has following advantages:(1) It is a natural product produced by microbial fermentation technology using renewable energy such as hydrocarbon; (2) It has high surface activity, no pollution to the environment, easy to biodegrade, good antibacterial effect and other excellent features; (3) It is consistent with the modern concept of the development of green chemistry, and used in a wide range of applications.In this paper, the basic structure, main characteristics, production process, purification methods and application of surfactin were reviewed in detail, and the research prospect on surfactin is discussed, which could facilitate the further study of surfactin.","articleNo":"","authorCnList":["李艳艳"," 张剑"],"authorEnList":["Li Yanyan"," Zhang Jian"],"authorList":["李艳艳"," 张剑"],"authors":"李艳艳, 张剑","authorsCn":"李艳艳, 张剑","authorsEn":"Li Yanyan, Zhang Jian","categoryName":"进展评述","categoryNameCn":"进展评述","categoryNameEn":"","citation":"李艳艳, 张剑. 表面活性肽的研究进展. 化学通报, 2017, 80(10): 918-924.","citationCn":"李艳艳, 张剑. 表面活性肽的研究进展. 化学通报, 2017, 80(10): 918-924.","citationEn":"李艳艳, 张剑. Research Progress in Surfactin. Chemistry, 2017, 80(10): 918-924.","doi":"","figContent":"hxtb-80-10-918-S1.jpg$$hxtb-80-10-918-2.jpg$$hxtb-80-10-918-3.jpg$$hxtb-80-10-918-4.jpg$$hxtb-80-10-918-5.jpg","figList":["hxtb-80-10-918-S1.jpg","hxtb-80-10-918-2.jpg","hxtb-80-10-918-3.jpg","hxtb-80-10-918-4.jpg","hxtb-80-10-918-5.jpg"],"firstFig":"hxtb-80-10-918-S1.jpg","fpage":"918","highCitedState":"","htmlCount":2282,"htmlFile":"","id":"6fbf119e-a2bd-4abb-9a8b-3696bd36937c","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"生物表面活性剂, Surfactin, 微生物发酵, 环状脂肽","keywordCn":"生物表面活性剂, Surfactin, 微生物发酵, 环状脂肽","keywordCnList":["生物表面活性剂"," Surfactin"," 微生物发酵"," 环状脂肽"],"keywordEn":"Biosurfactant, Surfactin, Microbial fermentation, Cyclic lipopeptide","keywordEnList":["Biosurfactant"," Surfactin"," Microbial fermentation"," Cyclic lipopeptide"],"keywordList":["生物表面活性剂"," Surfactin"," 微生物发酵"," 环状脂肽"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"924","oldUrl":"","pdfDownCount":73,"pdfSize":1404.8,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"表面活性肽的研究进展","titleCn":"表面活性肽的研究进展","titleEn":"Research Progress in Surfactin","viewCount":5314,"volume":"80","year":2017},{"abstractInfo":"近年来具有环境响应性的嵌段共聚物的研发受到了人们的广泛关注。该类型共聚物可以对外界环境刺激产生相应的结构、物理及化学性能的变化。根据外界环境刺激响应机理及类型的不同，可将其分为单一因素、双重因素以及三重因素刺激响应性嵌段共聚物三大类。针对每一类体系，本文重点综述了嵌段共聚物的设计合成、自组装以及应用等研究现状，并概括总结了各种有序聚集体（如胶束、囊泡等）随外界环境刺激（如pH、温度、光、CO<sub>2<\/sub>、氧化还原剂等）所作出的响应性变化。最后，对智能型嵌段共聚物在药物控释、纳米容器制备、生物功能材料等方面潜在的应用价值和今后可能的发展方向进行了展望。","abstractInfoCn":"近年来具有环境响应性的嵌段共聚物的研发受到了人们的广泛关注。该类型共聚物可以对外界环境刺激产生相应的结构、物理及化学性能的变化。根据外界环境刺激响应机理及类型的不同，可将其分为单一因素、双重因素以及三重因素刺激响应性嵌段共聚物三大类。针对每一类体系，本文重点综述了嵌段共聚物的设计合成、自组装以及应用等研究现状，并概括总结了各种有序聚集体（如胶束、囊泡等）随外界环境刺激（如pH、温度、光、CO<sub>2<\/sub>、氧化还原剂等）所作出的响应性变化。最后，对智能型嵌段共聚物在药物控释、纳米容器制备、生物功能材料等方面潜在的应用价值和今后可能的发展方向进行了展望。","abstractInfoEn":"In recent years, the research of environmentally responsive block copolymers has attracted wide attention from researchers.The structures, physical and chemical properties of the copolymers responded to change, when they were stimulated by external environment.According to the different response mechanism and types of external stimuli, the stimulus-responsive block copolymers were classified into three categories:single stimulus response, dual stimulus response and triple stimulus response.As for each type of system, this review discussed the design, synthesis, self-assembly and application of stimuli-responsive polymers in aqueous solution.Meanwhile, the various ordered aggregates (such as micelles, vesicles, etc.) changed with stimulus response (pH, temperature, light, CO<sub>2<\/sub>, redox agent, etc.) were summarized in brief.Finally, the potential application value of intelligent block copolymers in drug controlled release, the synthesis of nano container, biological functional materials and the possible development direction in the future were prospected.","articleNo":"","authorCnList":["魏渊"," 郑成"," 毛桃嫣"," 林璟"," 凌慧"],"authorEnList":["Wei Yuan"," Zheng Cheng"," Mao Taoyan"," Lin Jing"," Ling Hui"],"authorList":["魏渊"," 郑成"," 毛桃嫣"," 林璟"," 凌慧"],"authors":"魏渊, 郑成, 毛桃嫣, 林璟, 凌慧","authorsCn":"魏渊, 郑成, 毛桃嫣, 林璟, 凌慧","authorsEn":"Wei Yuan, Zheng Cheng, Mao Taoyan, Lin Jing, Ling Hui","categoryName":"进展评述","categoryNameCn":"进展评述","categoryNameEn":"","citation":"魏渊, 郑成, 毛桃嫣, 林璟, 凌慧. 环境响应性嵌段共聚物的合成、自组装及应用研究进展. 化学通报, 2017, 80(10): 925-934.","citationCn":"魏渊, 郑成, 毛桃嫣, 林璟, 凌慧. 环境响应性嵌段共聚物的合成、自组装及应用研究进展. 化学通报, 2017, 80(10): 925-934.","citationEn":"魏渊, 郑成, 毛桃嫣, 林璟, 凌慧. Progress in Syntheses, Self-Assembly and Applications of Environmental Responsive Block Copolymers. Chemistry, 2017, 80(10): 925-934.","doi":"","figContent":"hxtb-80-10-925-S1.jpg$$hxtb-80-10-925-1.jpg$$hxtb-80-10-925-2.jpg$$hxtb-80-10-925-3.jpg$$hxtb-80-10-925-4.jpg$$hxtb-80-10-925-5.jpg$$hxtb-80-10-925-6.jpg$$hxtb-80-10-925-7.jpg$$hxtb-80-10-925-8.jpg","figList":["hxtb-80-10-925-S1.jpg","hxtb-80-10-925-1.jpg","hxtb-80-10-925-2.jpg","hxtb-80-10-925-3.jpg","hxtb-80-10-925-4.jpg","hxtb-80-10-925-5.jpg","hxtb-80-10-925-6.jpg","hxtb-80-10-925-7.jpg","hxtb-80-10-925-8.jpg"],"firstFig":"hxtb-80-10-925-S1.jpg","fpage":"925","highCitedState":"","htmlCount":862,"htmlFile":"","id":"d614be74-e614-492a-82c2-a403d2894f46","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"嵌段共聚物, 环境响应性, 自组装, 胶束, 药物控释","keywordCn":"嵌段共聚物, 环境响应性, 自组装, 胶束, 药物控释","keywordCnList":["嵌段共聚物"," 环境响应性"," 自组装"," 胶束"," 药物控释"],"keywordEn":"Block copolymers, Stimuli responsive, Self assembly, Micelle, Drug controlled release","keywordEnList":["Block copolymers"," Stimuli responsive"," Self assembly"," Micelle"," Drug controlled release"],"keywordList":["嵌段共聚物"," 环境响应性"," 自组装"," 胶束"," 药物控释"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"934","oldUrl":"","pdfDownCount":32,"pdfSize":2303.06,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"环境响应性嵌段共聚物的合成、自组装及应用研究进展","titleCn":"环境响应性嵌段共聚物的合成、自组装及应用研究进展","titleEn":"Progress in Syntheses, Self-Assembly and Applications of Environmental Responsive Block Copolymers","viewCount":4275,"volume":"80","year":2017}],"研究论文":[{"abstractInfo":"本文以聚苯乙烯（PS）胶球为模板，通过一步水浴法结合煅烧后处理制备了不同比例的In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>空心球状复合材料（简写为In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>-H）。通过X-射线衍射、扫描电镜、X-射线光电子能谱、紫外-可见漫反射吸收光谱和氮气吸附-脱附等测试手段对该系列复合材料的结构、组成和形貌进行了表征。结果表明，In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>复合材料经PS模板处理后呈现空心球状结构，球壁由纳米粒子堆积而成。将In<sub>2<\/sub>O<sub>3<\/sub>与ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>复合后其光吸收性能呈现了一定的红移现象，且In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>-H（1:4）的比表面积较大（66.92m<sup>2<\/sup>·g<sup>-1<\/sup>）。同时，为了考察该复合材料的光催化性能，在多模式光催化条件下对甲基橙的降解情况进行了研究。结果表明，In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>-H（1:4）表现出较好的光催化性能，其光催化活性高于P25、ZrO<sub>2<\/sub>、In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>及其他体积比的In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>-H。","abstractInfoCn":"本文以聚苯乙烯（PS）胶球为模板，通过一步水浴法结合煅烧后处理制备了不同比例的In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>空心球状复合材料（简写为In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>-H）。通过X-射线衍射、扫描电镜、X-射线光电子能谱、紫外-可见漫反射吸收光谱和氮气吸附-脱附等测试手段对该系列复合材料的结构、组成和形貌进行了表征。结果表明，In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>复合材料经PS模板处理后呈现空心球状结构，球壁由纳米粒子堆积而成。将In<sub>2<\/sub>O<sub>3<\/sub>与ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>复合后其光吸收性能呈现了一定的红移现象，且In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>-H（1:4）的比表面积较大（66.92m<sup>2<\/sup>·g<sup>-1<\/sup>）。同时，为了考察该复合材料的光催化性能，在多模式光催化条件下对甲基橙的降解情况进行了研究。结果表明，In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>-H（1:4）表现出较好的光催化性能，其光催化活性高于P25、ZrO<sub>2<\/sub>、In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>及其他体积比的In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>-H。","abstractInfoEn":"In this paper, using polystyrene (PS) spheres as the template, In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub> hollow spheres (In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>-H) with different proportions were prepared by one-step method combined with calcination treatment.The structures, compositions and morphologies of as-prepared composites were characterized by XRD, XPS, UV-Vis/DRS, SEM and N<sub>2<\/sub> absorption-desorption measurements.The results showed that In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub> composites had a hollow spherical structure after being treated by PS template, and the spherical wall was formed by the nanoparticles.After compounding In<sub>2<\/sub>O<sub>3<\/sub> with ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>, its optical absorption had red-shifted slightly, moreover, the specific surface area of In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>-H (1:4) hollow sphere was larger (66.92 m<sup>2<\/sup>·g<sup>-1<\/sup>).In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>-H (1:4) showed higher photocatalytic activity in the degradation of methyl orange (MO) under multimodes photocatalysis, compared with P25, ZrO<sub>2<\/sub>, In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>, and other ratio In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>-H.","articleNo":"","authorCnList":["张晶晶"," 李莉"," 张鑫悦"," 周黔龙"," 郝玉婷"],"authorEnList":["Zhang Jingjing"," Li Li"," Zhang Xinyue"," Zhou Qianlong"," Hao Yuting"],"authorList":["张晶晶"," 李莉"," 张鑫悦"," 周黔龙"," 郝玉婷"],"authors":"张晶晶, 李莉, 张鑫悦, 周黔龙, 郝玉婷","authorsCn":"张晶晶, 李莉, 张鑫悦, 周黔龙, 郝玉婷","authorsEn":"Zhang Jingjing, Li Li, Zhang Xinyue, Zhou Qianlong, Hao Yuting","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"","citation":"张晶晶, 李莉, 张鑫悦, 周黔龙, 郝玉婷. 空心球形In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>纳米复合材料多模式光催化. 化学通报, 2017, 80(10): 935-941, 975.","citationCn":"张晶晶, 李莉, 张鑫悦, 周黔龙, 郝玉婷. 空心球形In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>纳米复合材料多模式光催化. 化学通报, 2017, 80(10): 935-941, 975.","citationEn":"张晶晶, 李莉, 张鑫悦, 周黔龙, 郝玉婷. Multimode Photocatalysis of Hollow Sphere In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub> Nanocomposite. Chemistry, 2017, 80(10): 935-941, 975.","doi":"","figContent":"hxtb-80-10-935-1.jpg$$hxtb-80-10-935-2.jpg$$hxtb-80-10-935-3.jpg$$hxtb-80-10-935-4.jpg$$hxtb-80-10-935-5.jpg$$hxtb-80-10-935-6.jpg$$hxtb-80-10-935-7.jpg","figList":["hxtb-80-10-935-1.jpg","hxtb-80-10-935-2.jpg","hxtb-80-10-935-3.jpg","hxtb-80-10-935-4.jpg","hxtb-80-10-935-5.jpg","hxtb-80-10-935-6.jpg","hxtb-80-10-935-7.jpg"],"firstFig":"hxtb-80-10-935-1.jpg","fpage":"935","highCitedState":"","htmlCount":980,"htmlFile":"","id":"fd9d659e-a65f-44c7-92a4-2e0f773e8417","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"聚苯乙烯, 一步法, 空心球, In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>, 多模式光催化","keywordCn":"聚苯乙烯, 一步法, 空心球, In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>, 多模式光催化","keywordCnList":["聚苯乙烯"," 一步法"," 空心球"," In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>"," 多模式光催化"],"keywordEn":"Polystyrene, One-step method, Hollow spheres, In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>, Multimodes photocatalysis","keywordEnList":["Polystyrene"," One-step method"," Hollow spheres"," In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>"," Multimodes photocatalysis"],"keywordList":["聚苯乙烯"," 一步法"," 空心球"," In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>"," 多模式光催化"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"941, 975","oldUrl":"","pdfDownCount":3,"pdfSize":2024.7,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"空心球形In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>纳米复合材料多模式光催化","titleCn":"空心球形In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub>纳米复合材料多模式光催化","titleEn":"Multimode Photocatalysis of Hollow Sphere In<sub>2<\/sub>O<sub>3<\/sub>/ZrO<sub>2<\/sub>-TiO<sub>2<\/sub> Nanocomposite","viewCount":2644,"volume":"80","year":2017},{"abstractInfo":"分别通过溶胶-凝胶法、浸渍法制备Cu/活性炭（AC）水解催化剂，考察了不同制备方法对水解脱硫性能的影响。利用XRD、BET、SEM等对载体及催化剂进行表征，分析了预处理对AC表面性质及不同制备方法对脱硫效率的影响，并探讨了水解脱硫的机理。结果表明，浸渍法所制备的水解催化剂活性优于溶胶-凝胶法制备的催化剂，在通过预处理增大了AC的比表面积、丰富了AC的孔道结构的基础上，浸渍法能均匀地将活性组分分散在载体表面及其孔道中，而溶胶-凝胶法制备的催化剂活性组分主要覆盖在载体的表面，不能有效进入孔道内，造成脱硫效率下降。在反应温度80℃、羰基硫浓度1.33g/m<sup>3<\/sup>、空速1500h<sup>-1<\/sup>、氧化铜质量分数为5%时，浸渍法制备的水解催化剂具有较高的硫容，可达29mgS/g。","abstractInfoCn":"分别通过溶胶-凝胶法、浸渍法制备Cu/活性炭（AC）水解催化剂，考察了不同制备方法对水解脱硫性能的影响。利用XRD、BET、SEM等对载体及催化剂进行表征，分析了预处理对AC表面性质及不同制备方法对脱硫效率的影响，并探讨了水解脱硫的机理。结果表明，浸渍法所制备的水解催化剂活性优于溶胶-凝胶法制备的催化剂，在通过预处理增大了AC的比表面积、丰富了AC的孔道结构的基础上，浸渍法能均匀地将活性组分分散在载体表面及其孔道中，而溶胶-凝胶法制备的催化剂活性组分主要覆盖在载体的表面，不能有效进入孔道内，造成脱硫效率下降。在反应温度80℃、羰基硫浓度1.33g/m<sup>3<\/sup>、空速1500h<sup>-1<\/sup>、氧化铜质量分数为5%时，浸渍法制备的水解催化剂具有较高的硫容，可达29mgS/g。","abstractInfoEn":"Cu/AC hydrolysis catalysts were prepared by sol-gel method and impregnation method, and the influence of the preparation methods on their desulfurization activities were investigated.XRD, BET and SEM were used to characterize the support and the catalysts.The influence of surface pretreatment and preparation methods on their desulfurization activities and the mechanism of hydrolysis desulfurization were discussed.The results showed that the desulfurization activity of the catalyst prepared by impregnation method is better than that prepared by sol-gel method.By expanding the specific surface area and increasing the number of pores of activated carbon in the process of pretreatment, the catalyst which was prepared by impregnated method can be uniformly dispersed on the surface of carrier and also into its pores.On the contrast, the catalyst prepared by sol-gel method resulted in active component dispersing only on the surface of activated carbon, leading to low desulfurization efficiency.Under the temperature of 80℃, 1.33g/m<sup>3<\/sup> of COS concentration, 1500h<sup>-1<\/sup> of space velocity, 5% of mass fraction copper oxide, Cu/AC hydrolysis catalyst prepared by impregnation method exhibits the highest sulfur capacity of 29mgS/g.","articleNo":"","authorCnList":["王广建"," 陈晓婷"," 田爱秀"," 王芳"],"authorEnList":["Wang Guangjian"," Chen Xiaoting"," Tain Aixiu"," Wang Fang"],"authorList":["王广建"," 陈晓婷"," 田爱秀"," 王芳"],"authors":"王广建, 陈晓婷, 田爱秀, 王芳","authorsCn":"王广建, 陈晓婷, 田爱秀, 王芳","authorsEn":"Wang Guangjian, Chen Xiaoting, Tain Aixiu, Wang Fang","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"","citation":"王广建, 陈晓婷, 田爱秀, 王芳. 活性炭基水解催化剂的制备及其脱硫性能的研究. 化学通报, 2017, 80(10): 942-947.","citationCn":"王广建, 陈晓婷, 田爱秀, 王芳. 活性炭基水解催化剂的制备及其脱硫性能的研究. 化学通报, 2017, 80(10): 942-947.","citationEn":"王广建, 陈晓婷, 田爱秀, 王芳. Preparation of Cu/AC Catalyst and Its Application for Desulfurization. Chemistry, 2017, 80(10): 942-947.","doi":"","figContent":"hxtb-80-10-942-1.jpg$$hxtb-80-10-942-2.jpg$$hxtb-80-10-942-3.jpg$$hxtb-80-10-942-4.jpg$$hxtb-80-10-942-5.jpg$$hxtb-80-10-942-6.jpg$$hxtb-80-10-942-7.jpg$$hxtb-80-10-942-8.jpg$$hxtb-80-10-942-S1.jpg","figList":["hxtb-80-10-942-1.jpg","hxtb-80-10-942-2.jpg","hxtb-80-10-942-3.jpg","hxtb-80-10-942-4.jpg","hxtb-80-10-942-5.jpg","hxtb-80-10-942-6.jpg","hxtb-80-10-942-7.jpg","hxtb-80-10-942-8.jpg","hxtb-80-10-942-S1.jpg"],"firstFig":"hxtb-80-10-942-1.jpg","fpage":"942","highCitedState":"","htmlCount":374,"htmlFile":"","id":"382d5735-f82e-4e17-b746-9c2b61c09a23","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"溶胶-凝胶法, 浸渍法, 催化水解, 羰基硫","keywordCn":"溶胶-凝胶法, 浸渍法, 催化水解, 羰基硫","keywordCnList":["溶胶-凝胶法"," 浸渍法"," 催化水解"," 羰基硫"],"keywordEn":"Sol-gel method, Impregnation method, Catalytic hydrolysis, Carbonyl sulfide","keywordEnList":["Sol-gel method"," Impregnation method"," Catalytic hydrolysis"," Carbonyl sulfide"],"keywordList":["溶胶-凝胶法"," 浸渍法"," 催化水解"," 羰基硫"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"947","oldUrl":"","pdfDownCount":5,"pdfSize":2183.01,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"活性炭基水解催化剂的制备及其脱硫性能的研究","titleCn":"活性炭基水解催化剂的制备及其脱硫性能的研究","titleEn":"Preparation of Cu/AC Catalyst and Its Application for Desulfurization","viewCount":1768,"volume":"80","year":2017},{"abstractInfo":"本文将三类粘结剂体系（PVDF、LA133和CMC+SBR）用于构筑锂硫电池硫正极，表征了不同粘结剂材料的官能团结构、结晶性能、热力学性质、电解液吸收性与粘结强度，考察了粘结剂种类对电极电化学性能的影响。结果表明，由1:1质量比的CMC+SBR制作的硫电极吸液率低，剥离强度低，循环稳定性较差；无定形LA133支持高的粘结强度，维稳电极结构的能力强；PVDF因半结晶状态制约粘结效果，制作的电极吸液量高，但电荷转移阻抗小。基于PVDF制作的硫正极具有相对最优的电化学性能，其0.2C下循环100周后保留的可逆容量达722mAh·g<sup>-1<\/sup>，容量保持率达82.9%。","abstractInfoCn":"本文将三类粘结剂体系（PVDF、LA133和CMC+SBR）用于构筑锂硫电池硫正极，表征了不同粘结剂材料的官能团结构、结晶性能、热力学性质、电解液吸收性与粘结强度，考察了粘结剂种类对电极电化学性能的影响。结果表明，由1:1质量比的CMC+SBR制作的硫电极吸液率低，剥离强度低，循环稳定性较差；无定形LA133支持高的粘结强度，维稳电极结构的能力强；PVDF因半结晶状态制约粘结效果，制作的电极吸液量高，但电荷转移阻抗小。基于PVDF制作的硫正极具有相对最优的电化学性能，其0.2C下循环100周后保留的可逆容量达722mAh·g<sup>-1<\/sup>，容量保持率达82.9%。","abstractInfoEn":"Three kinds of binder systems (PVDF, LA133, CMC+SBR with 1:1 mass ratio) were employed for constructing sulfur electrode of Li-S battery.The molecule structures, crystallization properties, thermodynamic properties, electrolyte absorption and binding strength of various materials were characterized.The effects of binder type on the electrochemical properties of Li-S battery were investigated.Low electrolyte uptake, weak peel strength and poor cycle capability appears in the sulfur cathode fabricated by CMC+SBR.Amorphous LA133 favors high binding strength and stable electrode structure.PVDF leads to poor adhesion quality due to its semi crystalline, and the constructed cathode produces high electrolyte absorption but low charge transfer resistance.In contrast, a reversible capacity of 722mAh·g<sup>-1<\/sup> and capacity retention rate of 82.9% after 100 cycles at 0.2 C is exhibited in the PVDF-based cathode, which is the best performance level among mentioned three binder systems.","articleNo":"","authorCnList":["卢海"," 李涛"," 王金磊"," 易大伟"," 赖延清"],"authorEnList":["Lu Hai"," Li Tao"," Wang Jinlei"," Yi Dawei"," Lai Yanqing"],"authorList":["卢海"," 李涛"," 王金磊"," 易大伟"," 赖延清"],"authors":"卢海, 李涛, 王金磊, 易大伟, 赖延清","authorsCn":"卢海, 李涛, 王金磊, 易大伟, 赖延清","authorsEn":"Lu Hai, Li Tao, Wang Jinlei, Yi Dawei, Lai Yanqing","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"","citation":"卢海, 李涛, 王金磊, 易大伟, 赖延清. 锂硫电池硫正极粘结剂的比较研究. 化学通报, 2017, 80(10): 948-952.","citationCn":"卢海, 李涛, 王金磊, 易大伟, 赖延清. 锂硫电池硫正极粘结剂的比较研究. 化学通报, 2017, 80(10): 948-952.","citationEn":"卢海, 李涛, 王金磊, 易大伟, 赖延清. Comparative Study on Different Binders used for Sulfur Cathode of Lithium Sulfur Battery. Chemistry, 2017, 80(10): 948-952.","doi":"","figContent":"hxtb-80-10-948-S1.jpg$$hxtb-80-10-948-1.jpg$$hxtb-80-10-948-2.jpg$$hxtb-80-10-948-3.jpg$$hxtb-80-10-948-4.jpg$$hxtb-80-10-948-5.jpg","figList":["hxtb-80-10-948-S1.jpg","hxtb-80-10-948-1.jpg","hxtb-80-10-948-2.jpg","hxtb-80-10-948-3.jpg","hxtb-80-10-948-4.jpg","hxtb-80-10-948-5.jpg"],"firstFig":"hxtb-80-10-948-S1.jpg","fpage":"948","highCitedState":"","htmlCount":1146,"htmlFile":"","id":"8f2e61e1-d8d0-483f-ad16-4f5b4176d82e","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"锂硫电池, 硫正极, 粘结剂, 电化学性能","keywordCn":"锂硫电池, 硫正极, 粘结剂, 电化学性能","keywordCnList":["锂硫电池"," 硫正极"," 粘结剂"," 电化学性能"],"keywordEn":"Lithium sulfur battery, Sulfur cathode, Binder, Electrochemical performance","keywordEnList":["Lithium sulfur battery"," Sulfur cathode"," Binder"," Electrochemical performance"],"keywordList":["锂硫电池"," 硫正极"," 粘结剂"," 电化学性能"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"952","oldUrl":"","pdfDownCount":42,"pdfSize":1310.21,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"锂硫电池硫正极粘结剂的比较研究","titleCn":"锂硫电池硫正极粘结剂的比较研究","titleEn":"Comparative Study on Different Binders used for Sulfur Cathode of Lithium Sulfur Battery","viewCount":3715,"volume":"80","year":2017},{"abstractInfo":"本文用水溶性的四硫富瓦烯（TTF）羧酸盐PropylTTFK<sub>2<\/sub>（<b>1<\/b>）合成了两种金属配合物Zn（L<sup>1<\/sup>）（Phen）<sub>2<\/sub>·CH<sub>3<\/sub>OH·2H<sub>2<\/sub>O（配合物<b>3<\/b>）和Cd（L<sup>1<\/sup>）（Phen）<sub>2<\/sub>·2CH<sub>3<\/sub>OH·H<sub>2<\/sub>O（配合物<b>4<\/b>）（L<sup>1<\/sup>=PropylTTF<sup>2-<\/sup>；Phen=1，10-phenanthroline）。经元素分析对配合物的组成进行分析，并通过X射线单晶衍射解析了配合物的晶体结构，表明分子中存在明显的分子间S…S及氢键作用。同时也研究了配合物的紫外、荧光和电化学性质，滴定实验显示两种配合物均是很好的TCNQ电子接受体。","abstractInfoCn":"本文用水溶性的四硫富瓦烯（TTF）羧酸盐PropylTTFK<sub>2<\/sub>（<b>1<\/b>）合成了两种金属配合物Zn（L<sup>1<\/sup>）（Phen）<sub>2<\/sub>·CH<sub>3<\/sub>OH·2H<sub>2<\/sub>O（配合物<b>3<\/b>）和Cd（L<sup>1<\/sup>）（Phen）<sub>2<\/sub>·2CH<sub>3<\/sub>OH·H<sub>2<\/sub>O（配合物<b>4<\/b>）（L<sup>1<\/sup>=PropylTTF<sup>2-<\/sup>；Phen=1，10-phenanthroline）。经元素分析对配合物的组成进行分析，并通过X射线单晶衍射解析了配合物的晶体结构，表明分子中存在明显的分子间S…S及氢键作用。同时也研究了配合物的紫外、荧光和电化学性质，滴定实验显示两种配合物均是很好的TCNQ电子接受体。","abstractInfoEn":"In this paper, two mononuclear coordination complexes Zn (L<sup>1<\/sup>)(Phen)<sub>2<\/sub>·CH<sub>3<\/sub>OH·2H<sub>2<\/sub>O (<b>3<\/b>) and Cd (L<sup>1<\/sup>)(Phen)<sub>2<\/sub>·2CH<sub>3<\/sub>OH·H<sub>2<\/sub>O (<b>4<\/b>), (L<sup>1<\/sup>=PropylTTF<sup>2-<\/sup>; Phen=1, 10-phenanthroline) derived from a water-soluble TTF-dicarboxylate salt PropylTTFK<sub>2<\/sub>(1)(PropylTTFK<sub>2<\/sub>=Propylenedithio-4', 5'-tetrathiafulavalene-4, 5-dicarboxylate dipotassium salt) were prepared.Their structures were characterized by elemental analysis.And the crystal structures of the complex <b>3<\/b> and <b>4<\/b> were analyzed by X-ray single crystal diffraction.Noticeable inter molecular S…S or/and H-bonding interactions have been found in <b>3<\/b> and <b>4<\/b>, resulting in the formation of 1D chain.All of them have been characterized by UV-Vis, fluorescence and electrochemistry.The titration of TCNQ shows these complexes can form classical electron-acceptor salt with TCNQ.","articleNo":"","authorCnList":["张睿"," 顾晓龙"," 庞欢"],"authorEnList":["Zhang Rui"," Gu Xiaolong"," Pang Huan"],"authorList":["张睿"," 顾晓龙"," 庞欢"],"authors":"张睿, 顾晓龙, 庞欢","authorsCn":"张睿, 顾晓龙, 庞欢","authorsEn":"Zhang Rui, Gu Xiaolong, Pang Huan","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"","citation":"张睿, 顾晓龙, 庞欢. 两种含有四硫富瓦烯羧酸和1, 10-菲咯啉配体的金属配合物的合成、结构及光学性质研究. 化学通报, 2017, 80(10): 958-962.","citationCn":"张睿, 顾晓龙, 庞欢. 两种含有四硫富瓦烯羧酸和1, 10-菲咯啉配体的金属配合物的合成、结构及光学性质研究. 化学通报, 2017, 80(10): 958-962.","citationEn":"张睿, 顾晓龙, 庞欢. Syntheses, Structures and Spectral Properties of Two Metal Complexes Containing Tetrathiafulvalene Carboxylic Acid and 1, 10-Phenanthroline Ligands. Chemistry, 2017, 80(10): 958-962.","doi":"","figContent":"hxtb-80-10-958-S1.jpg$$hxtb-80-10-958-1.jpg$$hxtb-80-10-958-2.jpg$$hxtb-80-10-958-3.jpg$$hxtb-80-10-958-4.jpg$$hxtb-80-10-958-5.jpg$$hxtb-80-10-958-6.jpg$$hxtb-80-10-958-7.jpg$$hxtb-80-10-958-8.jpg","figList":["hxtb-80-10-958-S1.jpg","hxtb-80-10-958-1.jpg","hxtb-80-10-958-2.jpg","hxtb-80-10-958-3.jpg","hxtb-80-10-958-4.jpg","hxtb-80-10-958-5.jpg","hxtb-80-10-958-6.jpg","hxtb-80-10-958-7.jpg","hxtb-80-10-958-8.jpg"],"firstFig":"hxtb-80-10-958-S1.jpg","fpage":"958","highCitedState":"","htmlCount":1146,"htmlFile":"","id":"daaa95cc-882d-4635-aaa3-1f83fa9ac3f3","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"TTF羧酸盐配合物, 晶体结构, 紫外光谱, 荧光, 电化学性质","keywordCn":"TTF羧酸盐配合物, 晶体结构, 紫外光谱, 荧光, 电化学性质","keywordCnList":["TTF羧酸盐配合物"," 晶体结构"," 紫外光谱"," 荧光"," 电化学性质"],"keywordEn":"Coordination complexes constructed by TTF dicarboxylate salt, Crystal structures, UV Vis spectrum, Fluorescence spectrum, Electrochemistry Properties","keywordEnList":["Coordination complexes constructed by TTF dicarboxylate salt"," Crystal structures"," UV Vis spectrum"," Fluorescence spectrum"," Electrochemistry Properties"],"keywordList":["TTF羧酸盐配合物"," 晶体结构"," 紫外光谱"," 荧光"," 电化学性质"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"962","oldUrl":"","pdfDownCount":4,"pdfSize":1833.02,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"两种含有四硫富瓦烯羧酸和1, 10-菲咯啉配体的金属配合物的合成、结构及光学性质研究","titleCn":"两种含有四硫富瓦烯羧酸和1, 10-菲咯啉配体的金属配合物的合成、结构及光学性质研究","titleEn":"Syntheses, Structures and Spectral Properties of Two Metal Complexes Containing Tetrathiafulvalene Carboxylic Acid and 1, 10-Phenanthroline Ligands","viewCount":2279,"volume":"80","year":2017},{"abstractInfo":"本文采用CCSD（T）/aug-cc-pVTZ//UB3LYP/6-311+G（2<i>d<\/i>，<i>p<\/i>）方法对HCl+NO<sub>3<\/sub>反应机理及速率常数进行了研究，并在此基础上考虑了水分子对该反应的影响。研究结果表明，HCl+NO<sub>3<\/sub>反应经历了生成产物为Cl+HNO<sub>3<\/sub>的通道，克服了13.67kcal·mol<sup>-1<\/sup>的能垒。加入水分子后，所得的产物并没有发生改变，但势能面却比裸反应复杂得多，经历了NO<sub>3<\/sub>…H<sub>2<\/sub>O+HCl、H<sub>2<\/sub>O…HCl+NO<sub>3<\/sub>和HCl…H<sub>2<\/sub>O+NO<sub>3<\/sub>三条反应通道。其中通道HCl…H<sub>2<\/sub>O+NO<sub>3<\/sub>为水分子参与反应的优势通道。此外，该通道比相同温度下裸反应的速率常数<i>k<\/i><sub>R1<\/sub>提高了0.33×10<sup>4<\/sup>~1.07×10<sup>7<\/sup>倍，且在298K时，<i>k<\/i>′<sub>RW3<\/sub>/<i>k<\/i>′<sub>total<\/sub>已达到95.9%，说明此时在实际大气环境中水分子对NO<sub>3<\/sub>+HCl反应有明显的影响。","abstractInfoCn":"本文采用CCSD（T）/aug-cc-pVTZ//UB3LYP/6-311+G（2<i>d<\/i>，<i>p<\/i>）方法对HCl+NO<sub>3<\/sub>反应机理及速率常数进行了研究，并在此基础上考虑了水分子对该反应的影响。研究结果表明，HCl+NO<sub>3<\/sub>反应经历了生成产物为Cl+HNO<sub>3<\/sub>的通道，克服了13.67kcal·mol<sup>-1<\/sup>的能垒。加入水分子后，所得的产物并没有发生改变，但势能面却比裸反应复杂得多，经历了NO<sub>3<\/sub>…H<sub>2<\/sub>O+HCl、H<sub>2<\/sub>O…HCl+NO<sub>3<\/sub>和HCl…H<sub>2<\/sub>O+NO<sub>3<\/sub>三条反应通道。其中通道HCl…H<sub>2<\/sub>O+NO<sub>3<\/sub>为水分子参与反应的优势通道。此外，该通道比相同温度下裸反应的速率常数<i>k<\/i><sub>R1<\/sub>提高了0.33×10<sup>4<\/sup>~1.07×10<sup>7<\/sup>倍，且在298K时，<i>k<\/i>′<sub>RW3<\/sub>/<i>k<\/i>′<sub>total<\/sub>已达到95.9%，说明此时在实际大气环境中水分子对NO<sub>3<\/sub>+HCl反应有明显的影响。","abstractInfoEn":"In this article, the mechanism and rate constant for the reaction of HCl+NO<sub>3<\/sub> without and with a water molecule were studied at the CCSD (T)/aug-cc-pVTZ//UB3LYP/6-311+G (2<i>d<\/i>, <i>p<\/i>) level of theory.The results show that there is only one channel for the NO<sub>3<\/sub>+HCl reaction, labeled as HNO<sub>3<\/sub>+Cl formation channel.When one water molecule is added, the product of the reaction does not change, but the potential energy surface of the reaction becomes quite complex, yielding three different channels of NO<sub>3<\/sub>…H<sub>2<\/sub>O+HCl, H<sub>2<\/sub>O…HCl+NO<sub>3<\/sub> and HCl…H<sub>2<\/sub>O+NO<sub>3<\/sub>.Channel HCl…H<sub>2<\/sub>O+NO<sub>3<\/sub> is the dominant channel for water molecules to participate in the reaction.Besides, the rate constant of HCl…H<sub>2<\/sub>O+NO<sub>3<\/sub> channel is predicted to be faster by 0.33×10<sup>4<\/sup>~1.07×10<sup>7<\/sup> times than that of the NO<sub>3<\/sub>+HCl naked reaction.Its effective rate constant <i>k<\/i>'<sub>RW3<\/sub>/<i>k<\/i>'<sub>total<\/sub> is up to 95.9% at 298 K, that is, the single water molecule has a obvious influence on the atmospheric reaction of NO<sub>3<\/sub>+HCl.","articleNo":"","authorCnList":["姚秋月"," 文明杰"," 鲁有松"," 李明静"," 张田雷"],"authorEnList":["Yao Qiuyue"," Wen Mingjie"," Lu Yousong"," Li Mingjing"," Zhang Tianlei"],"authorList":["姚秋月"," 文明杰"," 鲁有松"," 李明静"," 张田雷"],"authors":"姚秋月, 文明杰, 鲁有松, 李明静, 张田雷","authorsCn":"姚秋月, 文明杰, 鲁有松, 李明静, 张田雷","authorsEn":"Yao Qiuyue, Wen Mingjie, Lu Yousong, Li Mingjing, Zhang Tianlei","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"","citation":"姚秋月, 文明杰, 鲁有松, 李明静, 张田雷. 水分子催化HCl+NO<sub>3<\/sub>反应机理及动力学性质的理论研究. 化学通报, 2017, 80(10): 963-970.","citationCn":"姚秋月, 文明杰, 鲁有松, 李明静, 张田雷. 水分子催化HCl+NO<sub>3<\/sub>反应机理及动力学性质的理论研究. 化学通报, 2017, 80(10): 963-970.","citationEn":"姚秋月, 文明杰, 鲁有松, 李明静, 张田雷. Theoretical Study on the Mechanism and Kinetics for Water-Catalyzed HCl + NO<sub>3<\/sub> Reaction. Chemistry, 2017, 80(10): 963-970.","doi":"","figContent":"hxtb-80-10-963-S1.jpg$$hxtb-80-10-963-1.jpg$$hxtb-80-10-963-S2.jpg$$hxtb-80-10-963-2.jpg$$hxtb-80-10-963-3.jpg$$hxtb-80-10-963-4.jpg$$hxtb-80-10-963-5.jpg","figList":["hxtb-80-10-963-S1.jpg","hxtb-80-10-963-1.jpg","hxtb-80-10-963-S2.jpg","hxtb-80-10-963-2.jpg","hxtb-80-10-963-3.jpg","hxtb-80-10-963-4.jpg","hxtb-80-10-963-5.jpg"],"firstFig":"hxtb-80-10-963-S1.jpg","fpage":"963","highCitedState":"","htmlCount":526,"htmlFile":"","id":"0a3c5895-639f-45b9-bd0b-e1dffdb28eec","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"HCl+NO<sub>3<\/sub>, 水催化, 反应机理, 速率常数, 有效速率常数","keywordCn":"HCl+NO<sub>3<\/sub>, 水催化, 反应机理, 速率常数, 有效速率常数","keywordCnList":["HCl+NO<sub>3<\/sub>"," 水催化"," 反应机理"," 速率常数"," 有效速率常数"],"keywordEn":"NO<sub>3<\/sub>+HCl, Water-catalyzed, Reaction mechanism, Rate constant, Effective rate constant","keywordEnList":["NO<sub>3<\/sub>+HCl"," Water-catalyzed"," Reaction mechanism"," Rate constant"," Effective rate constant"],"keywordList":["HCl+NO<sub>3<\/sub>"," 水催化"," 反应机理"," 速率常数"," 有效速率常数"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"970","oldUrl":"","pdfDownCount":3,"pdfSize":1788.68,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"水分子催化HCl+NO<sub>3<\/sub>反应机理及动力学性质的理论研究","titleCn":"水分子催化HCl+NO<sub>3<\/sub>反应机理及动力学性质的理论研究","titleEn":"Theoretical Study on the Mechanism and Kinetics for Water-Catalyzed HCl + NO<sub>3<\/sub> Reaction","viewCount":1529,"volume":"80","year":2017},{"abstractInfo":"近几年雾霾频发，国内外有关雾霾的研究大量涌现，但相关研究主要集中在雾霾的组成、来源以及导致雾霾增强的气象条件及其变化规律等，很少采用物理化学原理进行讨论。作为气溶胶，雾霾涉及沉降与沉降平衡、表面吸附、扩散等诸多物理化学过程。通过构建简化模型并借助物理化学原理，本文对雾霾粒子的沉降与平衡、高度分布、雾与霾的区别、消除雾霾的方法等进行了讨论，得出了一些具有理论意义和应用价值的结论。","abstractInfoCn":"近几年雾霾频发，国内外有关雾霾的研究大量涌现，但相关研究主要集中在雾霾的组成、来源以及导致雾霾增强的气象条件及其变化规律等，很少采用物理化学原理进行讨论。作为气溶胶，雾霾涉及沉降与沉降平衡、表面吸附、扩散等诸多物理化学过程。通过构建简化模型并借助物理化学原理，本文对雾霾粒子的沉降与平衡、高度分布、雾与霾的区别、消除雾霾的方法等进行了讨论，得出了一些具有理论意义和应用价值的结论。","abstractInfoEn":"In recent years, dense haze and fog occurs with increasing frequency in the world.There are a lot of researches on the composition, formation, enhancement and evolution of haze and fog with emphasis on weather conditions and human activities, but with little concerns on analysis of haze and fog based on the principles of physical chemistry.As the most common aerosol, the occurrence and evolution of haze and fog are closely related to many physiochemical phenomena such as precipitation, precipitation equilibrium, surface adsorption of water vapor and diffusion.In this work, the height-distribution, the difference between dry/humid haze, and the effectiveness of wet-cleaning of haze are discussed based on a simplified model using some physical chemistry principles.Some important conclusions meaningful for people to have a correct understanding of haze and fog are reached.","articleNo":"","authorCnList":["齐维琳"," 韩绪爽"," 陆博"," 张树永"],"authorEnList":["Qi Weilin"," Han Xushuang"," Lu Bo"," Zhang Shuyong"],"authorList":["齐维琳"," 韩绪爽"," 陆博"," 张树永"],"authors":"齐维琳, 韩绪爽, 陆博, 张树永","authorsCn":"齐维琳, 韩绪爽, 陆博, 张树永","authorsEn":"Qi Weilin, Han Xushuang, Lu Bo, Zhang Shuyong","categoryName":"研究论文","categoryNameCn":"研究论文","categoryNameEn":"","citation":"齐维琳, 韩绪爽, 陆博, 张树永. 与雾霾相关的物理化学现象辨析. 化学通报, 2017, 80(10): 971-975.","citationCn":"齐维琳, 韩绪爽, 陆博, 张树永. 与雾霾相关的物理化学现象辨析. 化学通报, 2017, 80(10): 971-975.","citationEn":"齐维琳, 韩绪爽, 陆博, 张树永. Discussion on the Haze and Fog Based on the Principles of Physical Chemistry. Chemistry, 2017, 80(10): 971-975.","doi":"","figContent":"hxtb-80-10-971-1.jpg$$hxtb-80-10-971-2.jpg$$hxtb-80-10-971-3.jpg$$hxtb-80-10-971-4.jpg","figList":["hxtb-80-10-971-1.jpg","hxtb-80-10-971-2.jpg","hxtb-80-10-971-3.jpg","hxtb-80-10-971-4.jpg"],"firstFig":"hxtb-80-10-971-1.jpg","fpage":"971","highCitedState":"","htmlCount":366,"htmlFile":"","id":"ed467826-e8ce-4704-9ebc-99b60652176f","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"雾霾, 沉降, 吸附, 湿法除霾","keywordCn":"雾霾, 沉降, 吸附, 湿法除霾","keywordCnList":["雾霾"," 沉降"," 吸附"," 湿法除霾"],"keywordEn":"Haze and fog, Precipitation, Adsorption, Wet-cleaning","keywordEnList":["Haze and fog"," Precipitation"," Adsorption"," Wet-cleaning"],"keywordList":["雾霾"," 沉降"," 吸附"," 湿法除霾"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"975","oldUrl":"","pdfDownCount":12,"pdfSize":1383.34,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"与雾霾相关的物理化学现象辨析","titleCn":"与雾霾相关的物理化学现象辨析","titleEn":"Discussion on the Haze and Fog Based on the Principles of Physical Chemistry","viewCount":1480,"volume":"80","year":2017}],"其他":[{"abstractInfo":"Hereanovelcyanoacrylicester,(<i>E<\/i>)-2-cyano-3-[4-(2,4-difluorophenoxy)benzylamino]-3-methoxyacrylicacid2-ethoxyethylester(MAE),whichiscapableofsite-specificcleavageofsupercoiledpUC19DNA,wasintroduced.ThecleavagespecificitywasinvestigatedthroughUVabsorption,fluorescence,agarosegelelectrophoresis,andDNAsequencingtechniques.RedshiftandhypochromismintheabsorptionspectraandstaticfluorescencequenchingsuggestedthatatypicalintercalationoccurredbetweenDNAandMAE.Inaddition,detectablevarietiesinthegelelectrophoresisandDNAsequencingindicatedthatthecleavagewassite-specific,anddoublestrandsofDNAwerehydrolyzedstepbystep.","abstractInfoCn":"研究了一种新型丙烯酸酯（<i>E<\/i>）-2-氰基-3-[4-（2，4-二氟苯氧基）-苄氨基]-3-甲氧基-丙烯酸2-乙氧基乙酯（MAE）对超螺旋pUC19 DNA的定点切割作用。利用紫外吸收、荧光光谱、凝胶电泳和DNA测序技术研究其核酸切割特异性。紫外吸收光谱的红移和减色效应，以及静态荧光猝灭表明MAE与DNA的作用属于典型的插入模式。不仅如此，凝胶电泳条带的变化以及DNA测序结果表明DNA的定点切割是通过DNA双链的分步水解完成。","abstractInfoEn":"Here a novel cyanoacrylic ester, (<i>E<\/i>)-2-cyano-3-[4-(2, 4-difluorophenoxy) benzylamino]-3-methoxyacrylic acid 2-ethoxyethyl ester (MAE), which is capable of site-specific cleavage of supercoiled pUC19 DNA, was introduced.The cleavage specificity was investigated through UV absorption, fluorescence, agarose gel electrophoresis, and DNA sequencing techniques.Red shift and hypochromism in the absorption spectra and static fluorescence quenching suggested that a typical intercalation occurred between DNA and MAE.In addition, detectable varieties in the gel electrophoresis and DNA sequencing indicated that the cleavage was site-specific, and double strands of DNA were hydrolyzed step by step.","articleNo":"","authorCnList":["孟二娟"," 桑延晓"," 祝智慧"," 刘事林"," 胡方中"," 任雪玲"],"authorEnList":["Meng Erjuan"," Sang Yanxiao"," Zhu Zhihui"," Liu Shilin"," Hu Fangzhong"," Ren Xueling"],"authorList":["Meng Erjuan"," Sang Yanxiao"," Zhu Zhihui"," Liu Shilin"," Hu Fangzhong"," Ren Xueling"],"authors":"Meng Erjuan, Sang Yanxiao, Zhu Zhihui, Liu Shilin, Hu Fangzhong, Ren Xueling","authorsCn":"孟二娟, 桑延晓, 祝智慧, 刘事林, 胡方中, 任雪玲","authorsEn":"Meng Erjuan, Sang Yanxiao, Zhu Zhihui, Liu Shilin, Hu Fangzhong, Ren Xueling","categoryName":"","categoryNameCn":"研究论文","categoryNameEn":"","citation":"Meng Erjuan, Sang Yanxiao, Zhu Zhihui, Liu Shilin, Hu Fangzhong, Ren Xueling. Specific Cleavage of Supercoiled Plasmid DNA by (<i>E<\/i>)-2-Cyano-3-[4-(2, 4-difluorophenoxy) benzylamino]-3-methoxyacrylic acid 2-Ethoxyethyl Ester. Chemistry, 2017, 80(10): 953-957.","citationCn":"Meng Erjuan, Sang Yanxiao, Zhu Zhihui, Liu Shilin, Hu Fangzhong, Ren Xueling. (<i>E<\/i>)-2-氰基-3-[4-(2, 4-二氟苯氧基)-苄氨基]-3-甲氧基-丙烯酸2-乙氧基乙酯对超螺旋质粒DNA的特异性切割. 化学通报, 2017, 80(10): 953-957.","citationEn":"Meng Erjuan, Sang Yanxiao, Zhu Zhihui, Liu Shilin, Hu Fangzhong, Ren Xueling. Specific Cleavage of Supercoiled Plasmid DNA by (<i>E<\/i>)-2-Cyano-3-[4-(2, 4-difluorophenoxy) benzylamino]-3-methoxyacrylic acid 2-Ethoxyethyl Ester. Chemistry, 2017, 80(10): 953-957.","doi":"","figContent":"hxtb-80-10-953-S1.jpg$$hxtb-80-10-953-1.jpg$$hxtb-80-10-953-2.jpg$$hxtb-80-10-953-3.jpg$$hxtb-80-10-953-4.jpg","figList":["hxtb-80-10-953-S1.jpg","hxtb-80-10-953-1.jpg","hxtb-80-10-953-2.jpg","hxtb-80-10-953-3.jpg","hxtb-80-10-953-4.jpg"],"firstFig":"hxtb-80-10-953-S1.jpg","fpage":"953","highCitedState":"","htmlCount":201,"htmlFile":"","id":"1065397c-89c4-4d5a-ae3f-a6e1aae4a686","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"DNA cleavage, Acrylic ester, Spectroscopy, DNA sequencing","keywordCn":"DNA切割, 丙烯酸酯, 光谱, DNA测序","keywordCnList":["DNA切割"," 丙烯酸酯"," 光谱"," DNA测序"],"keywordEn":"DNA cleavage, Acrylic ester, Spectroscopy, DNA sequencing","keywordEnList":["DNA cleavage"," Acrylic ester"," Spectroscopy"," DNA sequencing"],"keywordList":["DNA cleavage"," Acrylic ester"," Spectroscopy"," DNA sequencing"],"language":"en","latestInfo":"","latestState":"","latestStateEn":"","lpage":"957","oldUrl":"","pdfDownCount":2,"pdfSize":1613.57,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"Specific Cleavage of Supercoiled Plasmid DNA by (<i>E<\/i>)-2-Cyano-3-[4-(2, 4-difluorophenoxy) benzylamino]-3-methoxyacrylic acid 2-Ethoxyethyl Ester","titleCn":"(<i>E<\/i>)-2-氰基-3-[4-(2, 4-二氟苯氧基)-苄氨基]-3-甲氧基-丙烯酸2-乙氧基乙酯对超螺旋质粒DNA的特异性切割","titleEn":"Specific Cleavage of Supercoiled Plasmid DNA by (<i>E<\/i>)-2-Cyano-3-[4-(2, 4-difluorophenoxy) benzylamino]-3-methoxyacrylic acid 2-Ethoxyethyl Ester","viewCount":1171,"volume":"80","year":2017}],"研究简报":[{"abstractInfo":"依据活性结构单元的拼合原理，以2-呋喃甲醛和4-氟苯乙酮为原料出发，经Aldol缩合、脱水、哌嗪取代反应生成4’-（1-哌嗪基）呋喃查尔酮（2）后，再与酰氯和磺酰氯反应，得到了10个未见报道的含哌嗪取代的呋喃查尔酮衍生物，其结构经<sup>1<\/sup>HNMR和<sup>13<\/sup>CNMR确证。采用小鼠巨噬细胞Raw264.7模型初步测试了目标化合物的体外抗炎活性，结果表明，磺酰胺类化合物的抗炎活性要优于酰胺类化合物，特别是化合物4d能有效抑制NO的生成（IC<sub>50<\/sub>=3.88μmol/L），与阳性对照药地塞米松活性相当。","abstractInfoCn":"依据活性结构单元的拼合原理，以2-呋喃甲醛和4-氟苯乙酮为原料出发，经Aldol缩合、脱水、哌嗪取代反应生成4’-（1-哌嗪基）呋喃查尔酮（2）后，再与酰氯和磺酰氯反应，得到了10个未见报道的含哌嗪取代的呋喃查尔酮衍生物，其结构经<sup>1<\/sup>H NMR和<sup>13<\/sup>C NMR确证。采用小鼠巨噬细胞Raw 264.7模型初步测试了目标化合物的体外抗炎活性，结果表明，磺酰胺类化合物的抗炎活性要优于酰胺类化合物，特别是化合物4d能有效抑制NO的生成（IC<sub>50<\/sub>=3.88μmol/L），与阳性对照药地塞米松活性相当。","abstractInfoEn":"A series of new 4'-(<i>N<\/i>-substitued-1-piperazinyl) furanyl chalcone derivatives have been synthesized, and their structures were characterized by <sup>1<\/sup>H NMR and <sup>13<\/sup>C NMR.The <i>in vitro<\/i> anti-inflammatory activities of synthesized compounds were evaluated in lipopolysaccharide (LPS)-stimulated RAW-264.7 macrophages.The results demonstrated that sulfamide compounds showed higher anti-inflammatory activity than their amide analogs.In particular, compound 4d was found to be the most potent anti-inflammatory compound (IC<sub>50<\/sub>=3.88μmol/L), which has a comparable activity to the positive control drug dexamethasone.","articleNo":"","authorCnList":["高慧"," 郑喜"," 王斯"," 杨林丽"," 毛泽伟"],"authorEnList":["Gao Hui"," Zheng Xi"," Wang Si"," Yang Linli"," Mao Zewei"],"authorList":["高慧"," 郑喜"," 王斯"," 杨林丽"," 毛泽伟"],"authors":"高慧, 郑喜, 王斯, 杨林丽, 毛泽伟","authorsCn":"高慧, 郑喜, 王斯, 杨林丽, 毛泽伟","authorsEn":"Gao Hui, Zheng Xi, Wang Si, Yang Linli, Mao Zewei","categoryName":"研究简报","categoryNameCn":"研究简报","categoryNameEn":"","citation":"高慧, 郑喜, 王斯, 杨林丽, 毛泽伟. 含酰基哌嗪片段的呋喃查尔酮衍生物的合成及其抗炎活性研究. 化学通报, 2017, 80(10): 976-979.","citationCn":"高慧, 郑喜, 王斯, 杨林丽, 毛泽伟. 含酰基哌嗪片段的呋喃查尔酮衍生物的合成及其抗炎活性研究. 化学通报, 2017, 80(10): 976-979.","citationEn":"高慧, 郑喜, 王斯, 杨林丽, 毛泽伟. Synthesis and Anti-Inflammatory Evaluation of Acylpiperazine Substituted Furanyl Chalcone Derivatives. Chemistry, 2017, 80(10): 976-979.","doi":"","figContent":"hxtb-80-10-976-S1.jpg","figList":["hxtb-80-10-976-S1.jpg"],"firstFig":"hxtb-80-10-976-S1.jpg","fpage":"976","highCitedState":"","htmlCount":83,"htmlFile":"","id":"783342fd-05f4-4882-acd2-ad066938afbb","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"呋喃查尔酮衍生物, 合成, 抗炎活性","keywordCn":"呋喃查尔酮衍生物, 合成, 抗炎活性","keywordCnList":["呋喃查尔酮衍生物"," 合成"," 抗炎活性"],"keywordEn":"Furanyl chalcone derivatives, Synthesis, Anti-inflammatory activity","keywordEnList":["Furanyl chalcone derivatives"," Synthesis"," Anti-inflammatory activity"],"keywordList":["呋喃查尔酮衍生物"," 合成"," 抗炎活性"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"979","oldUrl":"","pdfDownCount":5,"pdfSize":1219.74,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"含酰基哌嗪片段的呋喃查尔酮衍生物的合成及其抗炎活性研究","titleCn":"含酰基哌嗪片段的呋喃查尔酮衍生物的合成及其抗炎活性研究","titleEn":"Synthesis and Anti-Inflammatory Evaluation of Acylpiperazine Substituted Furanyl Chalcone Derivatives","viewCount":887,"volume":"80","year":2017},{"abstractInfo":"在甲苯中，以ZnBr<sub>2<\/sub>为催化剂、4-二甲氨基吡啶为碱，通过<i>N<\/i>-Boc取代的炔基胺类化合物的环化反应合成了5位取代的2-噁唑烷酮类化合物。考察了催化剂种类、碱、温度等对反应的影响，在优化条件下以良好的产率得到了一系列目标产物。","abstractInfoCn":"在甲苯中，以ZnBr<sub>2<\/sub>为催化剂、4-二甲氨基吡啶为碱，通过<i>N<\/i>-Boc取代的炔基胺类化合物的环化反应合成了5位取代的2-噁唑烷酮类化合物。考察了催化剂种类、碱、温度等对反应的影响，在优化条件下以良好的产率得到了一系列目标产物。","abstractInfoEn":"Various 5-substitued 2-oxazolidinones were obtained by a ZnBr<sub>2<\/sub> catalyzed cyclization of <i>N<\/i>-Boc alkynylamines in toluene with DMAP as a base.The effects of catalyst type, alkali and temperature on the reaction were investigated.A series of target products were obtained with good yield under the optimized conditions.","articleNo":"","authorCnList":["张卫卫"],"authorEnList":["Zhang Weiwei"],"authorList":["张卫卫"],"authors":"张卫卫","authorsCn":"张卫卫","authorsEn":"Zhang Weiwei","categoryName":"研究简报","categoryNameCn":"研究简报","categoryNameEn":"","citation":"张卫卫. ZnBr<sub>2<\/sub>催化合成2-噁唑烷酮类化合物. 化学通报, 2017, 80(10): 980-983, 952.","citationCn":"张卫卫. ZnBr<sub>2<\/sub>催化合成2-噁唑烷酮类化合物. 化学通报, 2017, 80(10): 980-983, 952.","citationEn":"张卫卫. ZnBr<sub>2<\/sub> Catalyzed Syntheses of 2-Oxazolidinones. Chemistry, 2017, 80(10): 980-983, 952.","doi":"","figContent":"hxtb-80-10-980-S1.jpg$$hxtb-80-10-980-S2.jpg","figList":["hxtb-80-10-980-S1.jpg","hxtb-80-10-980-S2.jpg"],"firstFig":"hxtb-80-10-980-S1.jpg","fpage":"980","highCitedState":"","htmlCount":159,"htmlFile":"","id":"ef5ea376-2b30-4e23-b279-7d054970544a","issnPpub":"0441-3776","issue":"10","journalPublishId":"hxtb","journalReferenceCodeType":0,"journalTitleCn":"化学通报","journalTitleEn":"Chemistry","keyword":"ZnBr<sub>2<\/sub>, 4-二甲氨基吡啶, <i>N<\/i>-Boc取代的炔基胺, 2-噁唑烷酮, 环化","keywordCn":"ZnBr<sub>2<\/sub>, 4-二甲氨基吡啶, <i>N<\/i>-Boc取代的炔基胺, 2-噁唑烷酮, 环化","keywordCnList":["ZnBr<sub>2<\/sub>"," 4-二甲氨基吡啶"," <i>N<\/i>-Boc取代的炔基胺"," 2-噁唑烷酮"," 环化"],"keywordEn":"ZnBr<sub>2<\/sub>, 4-Dimethylaminopyridine, <i>N<\/i>-Boc alkynylamines, 2-Oxazolidinones, Cyclization","keywordEnList":["ZnBr<sub>2<\/sub>"," 4-Dimethylaminopyridine"," <i>N<\/i>-Boc alkynylamines"," 2-Oxazolidinones"," Cyclization"],"keywordList":["ZnBr<sub>2<\/sub>"," 4-二甲氨基吡啶"," <i>N<\/i>-Boc取代的炔基胺"," 2-噁唑烷酮"," 环化"],"language":"zh","latestInfo":"","latestState":"","latestStateEn":"","lpage":"983, 952","oldUrl":"","pdfDownCount":4,"pdfSize":1308.13,"pubDate":"2017-10-01","recommendState":"","releaseState":"1","secCount":0,"title":"ZnBr<sub>2<\/sub>催化合成2-噁唑烷酮类化合物","titleCn":"ZnBr<sub>2<\/sub>催化合成2-噁唑烷酮类化合物","titleEn":"ZnBr<sub>2<\/sub> Catalyzed Syntheses of 2-Oxazolidinones","viewCount":1786,"volume":"80","year":2017}]}