Citation: Chen Lijuan, Li Pu, Wang Xiaobin, Ruan Xianghui, Xue Wei. Synthesis and Biological Activities of Penta-1, 4-diene-3-one Oxime Ether Derivatives[J]. Chemistry, ;2017, 80(12): 1156-1159. shu

Synthesis and Biological Activities of Penta-1, 4-diene-3-one Oxime Ether Derivatives

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025

Corresponding author: Xue Wei, wxue@gzu.edu.cn
Received Date: 20 May 2017
Accepted Date: 12 September 2017

Figures(1)

Seven novel penta-1, 4-diene-3-one oxime ether derivatives were synthesized by converting carbonyl groups in the 1, 4-pentadien-3-ones to an oxime ether groups, and their structures were confirmed by IR, ¹H NMR, ¹³C NMR and ESI-MS. Antiviral bioassays at the concentration of 500mg/L indicated that compounds 4c, 4f, and 4g exhibite better curative activity against tobacco mosaic virus (TMV) (49.6%, 53.6% and 47.4%, respectively) than ribavirin (45.2%). The protective activities of compounds 4b, 4c, 4f and 4g against TMV are 57.2%, 58.4%, 58.9% and 59.0% respectively, which were lower than that of ribavirin (61.8%). The inactivition activities of compounds 4a, 4b, 4c and 4g against TMV are 95.5%, 92.6%, 95.0% and 89.5% respectively, which are superior to that of ribavirin (87.9%). These results indicated that penta-1, 4-diene-3-one oxime ether derivatives have good inhibitory effect against plant virus, and that some compounds with potent anti-plant viral activities can be obtained after appropriate modifications on structures of penta-1, 4-diene-3-one oxime ethers.
- Penta-1, 4-diene-3-one,
- Oxime ether,
- Antiviral activity,
- Tobacco mosaic virus
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