Syntheses of 3,7-disubstitrted 1,4-benzepin-2-one

A series of 3-methoxycarbonylpropoxy-7-(imidazol-4-ylpropinamide)-1, 3-dihydrogen-1-methyl-5-phenyl-2H-1, 4-benzodiazepin-2-ones, as farnesyltransferase(Ftase) inhibitors, were synthesized. The preparation of the key intermediate, 7-amino-3-methoxycabonylpropoxy-1- methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, was improved.