Citation: Chen Genqiang, Yang Jinming, Sun Di, Han Xiaoxiao, Tian YueE, Liu Shengming, Jiang Jia, Che Zhiping. Syntheses and Insecticidal Activities of Some Paeonol-Based Phenylsulfonylhydrazone Derivatives Against Mythimna separata In Vivo[J]. Chemistry, ;2020, 83(2): 139-143. shu

Syntheses and Insecticidal Activities of Some Paeonol-Based Phenylsulfonylhydrazone Derivatives Against Mythimna separata In Vivo

Laboratory of Pesticidal Design&Synthesis, College of Forestry, Henan University of Science and Technology, Luoyang, 471023

Corresponding author: Che Zhiping, zhipingche@163.com
Received Date: 22 October 2019
Accepted Date: 4 November 2019

Figures(3)

Paeonol can inhibite acetylcholinesterase (AChE) and across the blood-brain barrier (BBB), which lays a solid foundation for the development of new insecticides. In view of this, five paeonol-based phenylsulfonylhydrazone derivatives (5a~5e) were synthesized and evaluated for their in vivo insecticidal activity against a crop-threatening agricultural pest, the pre-third-instar larvae of Mythimna separate, at the concentration of 1mg/mL. Among all the target compounds, compound 5e exhibited significant insecticidal activity, and the final corrected mortality (FMR=50.0%) was equivalent to toosendanin. Meanwhile, some interesting structure-activity relationship results were also discovered:modification of carbonyl on paeonol is acceptable; modification of imino group of intermediate 3 is important for insecticidal activity, and different sulfonated substituents show significant difference in activity. In addition, the insects fed with leaves containing the test compound showed developmental abnormalities during larve, pupae and adult stages.
- Natural product,
- Paeonol,
- Phenylsulfonylhydrazone,
- Insecticidal activity,
- Structure-activity relationship
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