Citation: Liang CUI, Feng QIU, Nai Li WANG, Xin Sheng YAO. A New Glucuronidated Metabolite of Andrographolide in Human[J]. Chinese Chemical Letters, ;2005, 16(3): 369-371. shu

A New Glucuronidated Metabolite of Andrographolide in Human

Liang CUI ^1, ,
Feng QIU ¹ ,
Nai Li WANG ^1,2 ,
Xin Sheng YAO ^1,2

1.
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016;
2.
Traditional Chinese Medicines & Natural Products Research Center Shenzhen, Shenzhen 518057

Received Date: 9 March 2004

A new andrographolide metabolite 1 was isolated from human urine samples after oral administration. The structure was determined to be 3-carbonylandrographolide-19-O-β-D-glucuronide on the basis of chemical evidences and spectral analysis, especially by 2D-NMR techniques.
- Andrographolide,
- metabolite in human urine,
- 3-carbonyl-andrographolide-19-O-β-D-glucuronide,
- oxygenated metabolite,
- glucuronide conjugate.
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