Citation: Xing LU, Yue WANG, Hai Yuan ZHANG, Chun Ji NIU, Jia Zuan NI. Tb(Ⅲ) Speciation in Human Blood Plasma by Computer Simulation[J]. Chinese Chemical Letters, ;2001, 12(9): 809-812. shu

Tb(Ⅲ) Speciation in Human Blood Plasma by Computer Simulation

Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022

Received Date: 20 February 2001

Fund Project: This work was supported by the National Natural Science Foundation of China (grant No. 29890280 and 29971029).

A multi-phase model was developed and Tb(Ⅲ) speciation in human blood plasma was studied. At a concentration below 3.744×10^-4mol/L (or at the concentration), Tb(Ⅲ) is mostly bound to phosphate to form precipitate of TbPO₄. As the concentration of Tb(Ⅲ) increases,phosphate is exceeded and another kind of precipitate of Tb₂(CO₃)₃ appears. Among soluble Tb(Ⅲ) species, Tb(Ⅲ) mainly distribute in [Tb (Tf)] at low concentration and in [Tb (HSA)], [Tb₂(Tf], [Tb (IgG)], [Tb (Lactate)]²⁺, [Tb (CitArgH)] and free Tb(Ⅲ) at high concentration.
- Terbium(Ⅲ),
- speciation,
- human blood plasma,
- computer simulation
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