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Citation: Yu Xiang, Chen Yafang. Evaluation of 2, 3-Diphenyl-4-thiazolidinone Derivatives as Antifungal Agents[J]. Chemistry, ;2018, 81(8): 759-762. shu

Evaluation of 2, 3-Diphenyl-4-thiazolidinone Derivatives as Antifungal Agents

Yu Xiang ^, ,
Chen Yafang

College of pharmacy, Guiyang University of Chinese Medicine, Guiyang 550025

Corresponding author: Yu Xiang, yuxiangjx@126.com
Received Date: 26 February 2018
Accepted Date: 17 April 2018

Figures(2)

A series of 2, 3-diphenyl-4-thiazolidinone derivatives were synthesized and characterized by ¹H NMR and MS. Their antifungal activities were also evaluated in vitro at the concentration of 100 μg/mL against seven phytopathogenic fungi, namely F. graminearum, A. alternata, F.oxysporium f. sp. vasinfectum, P.oryzae, V.mali, A.solani and A.brassicae. Among all compounds, 4g exhibits a potential antifungal activity against V. mali with the highest inhibition rates of 62.7%. Introduction of the methyl group at the phenyl ring of 4-thiazolidinone derivatives could generally increase the potency.
- 4-Thiazolidinone,
- Synthesis,
- Antifungal activity
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