Citation: Jun LIU, Xian Ming HU, Han Sheng XU. Synthesis and Structural Determination of (2R,4S,5S)-(+)-Threo-5-(2,2-dichloroacetamido)-4-(4-nitrophenyl)-2-aryl-1,3-dioxanes[J]. Chinese Chemical Letters, ;1999, 10(3): 199-200. shu

Synthesis and Structural Determination of (2R,4S,5S)-(+)-Threo-5-(2,2-dichloroacetamido)-4-(4-nitrophenyl)-2-aryl-1,3-dioxanes

Department of Chemistry, Wuhan University, Wuhan 430072

Received Date: 2 August 1998

Fund Project: This work was supported by the fundation of national education committee for the scholars back from abroad, the science and technology fundation of Wuhan city.Red Heart K (Group) Co.Ltd. We are grateful to Prof.Chui Yuxing (Beijing Medical University.NMR Lab) for technical assistance.

(2R,4S,5S)-(+)-threo-5-(2,2-dichloroacetamido)-4-(4-nitrophenyl)-2-aryl-l,3-dioxanes, were synthesized with high diastereoselectivity and good yields.The structures of acetals were determined and the configurations were confirmed by 2D-NMR (NOESY).
- Acetals,
- diastereoselective synthesis,
- chloramphenicol,
- 2D-NMR
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