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Citation: Chen Wang, Hu Daihua, Feng Zili. Improved Synthesis of 1α-Hydroxydehydroepiandrosterone[J]. Chemistry, ;2019, 82(12): 1126-1129. shu

Improved Synthesis of 1α-Hydroxydehydroepiandrosterone

College of Biological Science & Engineering, Shaanxi University of Technology, Hanzhong 723001

Corresponding author: Chen Wang, chenwang0519@126.com
Received Date: 1 July 2019
Accepted Date: 16 August 2019

Figures(1)

1α-hydroxydehydroepiandrosterone was prepared from androsta-1, 4-diene-3, 17-dione through six steps including bromination and elimination, protection of carbonyl group, oxidation, incomplete hydrogenation and deprotection, with an overall yield of 27.3%. The method is economical, technically feasible, and environment-friendly; it can provide reference for the scale production of 1α-hydroxydehydroepiandrosterone and research of vitamin D drugs.
- 1α-hydroxydehydroepiandrosterone,
- Androsta-1, 4-diene-3, 17-dione,
- Incomplete hydrogenation
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