Citation: Shi Detai, He Xiaopeng. Albumin: A Multifunctional Carrier for Cancer Theranostics[J]. Chemistry, ;2020, 83(3): 195-208. shu

Albumin: A Multifunctional Carrier for Cancer Theranostics

Shi Detai ^1,2 ,
He Xiaopeng ^1,,

1.
Key Laboratory for Advanced Materials, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237
2.
School of Materials Science and Engineering, Jingdezhen Ceramic Institute, Jingdezhen, 333403

Corresponding author: He Xiaopeng, xphe@ecust.edu.cn
Received Date: 1 December 2019
Accepted Date: 23 December 2019

Figures(10)

Serum albumin has a long circulatory half-life in blood, and can be actively internalized by tumor cells through albumin receptor-mediated pathways. Consequently, this natural biomacromolecule has been recognized as one of the most promising carriers for building theranostic agents. Multifunctional albumin carriers have been used for conjugation with a variety of imaging agents and therapeutic agents towards cancer theranostics. Both covalent and non-covalent strategies have been developed for albumin functionalization. In this review, we summarize the recent progress and propose future perspectives in regard to the exploitation of albumin carriers for precision cancer theranostics.
- Serum albumin,
- Carriers,
- Antitumor,
- Theranostics
1. [1]
  Ganguly P, Breen A, Pillai S C.. Biomater ACS. Sci. Eng., 2018, 4(7):2237-2275.
2. [2]
  Parodi A, Miao J, Soond S M, et al.. Biomolecules, 2019, 9(6):218.
3. [3]
  Chen X, Lau J, Jacobson O, et al.. Bioconjugate Chem., 2019, 30(3):487-502.
4. [4]
  Hoogenboezem E N, Duvall C L.. Adv. Drug Deliv. Rev., 2018, 130:73-89.
5. [5]
  Sand K M K, Bern M, Nilsen J, et al.. Front. Immunol., 2015, 5:682.
6. [6]
  Stapleton N M, Stemerding A M.. Immunol. Rev., 2015, 268(1):253-268.
7. [7]
  Chen G, Roy I, Yang C, et al.. Chem. Rev., 2016, 116(5):2826-2885.
8. [8]
  Qin S, Zhang A, Zhang X.. Small, 2018, 14(45):1802417.
9. [9]
  Bjo M, Thurecht K J, Michael M, et al.. Nano ACS, 2017, 11(10):9594-9613.
10. [10]
  Wang Y, Shi Q, Dong M, et al.. Chem. Rev., 2011, 111(12):7652-7709.
11. [11]
  Min Y, Caster J M, Eblan M J, et al.. Chem. Rev., 2015, 115(19):11147-11190.
12. [12]
  Merlot A M, Kalinowski D S, Richardson D R.. Front. Physiol., 2014, 5:299.
13. [13]
  Bottini N, Xiao H, Bottini M, et al.. Nano ACS, 2019, 13(5):5036-5048.
14. [14]
  Zhao P, Wang Y, Wu A, et al.. ChemBioChem, 2018, 19(17):1796-1805.
15. [15]
  Sun Q, Ojha T, Kiessling F, et al.. Biomacromolecules, 2017, 18(5):1449-1459.
16. [16]
  Zhao Y, Marcel Y L.. Biochemistry, 1996, 35(22):7174-7180.
17. [17]
  Bienk K, Lykke M, Maria M, et al.. J. Control. Release, 2016, 232:143-151.
18. [18]
  Callmann C E, Leguyader C L M, Burton S T, et al.. J. Am. Chem. Soc., 2019, 141(30):11765-11769.
19. [19]
  Zheng Y, Suntharalingam K, Johnstone T C, et al.. J. Am. Chem. Soc., 2014, 136(24):8790-8798.
20. [20]
  Browning R J, James P, Reardon T, et al.. Nano ACS, 2017, 11(9):8560-8578.
21. [21]
  Ma J, Wang Q, Huang Z, et al.. J. Med. Chem., 2017, 60(13):5736-5748.
22. [22]
  Jing C, Zhang H, Zou J, et al.. Angew. Chem., 2018, 130(29):9132-9135.
23. [23]
  Wen X, Shi C, Xu D, et al.. Mol. Pharm., 2019, 16(2):816-824.
24. [24]
  Gou Y, Zhang Y, Zhang Z, et al.. Mol. Pharm., 2017, 14(6):1861-1873.
25. [25]
  Popova M, Soboleva T, Ayad S, et al.. J. Am. Chem. Soc., 2018, 140(30):9721-9729.
26. [26]
  Qi J, Zhang Y, Gou Y, et al.. Mol. Pharm., 2016, 13(9):3098-3105.
27. [27]
  Chen Q, Liu Z.. Adv. Mater., 2016, 28(47):10557-10566.
28. [28]
  Zorzi A, Linciano S, Angelini A.. MedChemComm, 2019, 10(7):1068-1081.
29. [29]
  Wang C, Zhang C, Li Z, et al.. Biomacromolecules, 2018, 19(3):773-781.
30. [30]
  Yousefpour P, Mcdaniel J R, Prasad V, et al.. Nano Lett., 2018, 18(12):7784-7793.
31. [31]
  Yousefpour P, Ahn L, Tewksbury J, et al.. Small, 2019, 15(37):1804452.
32. [32]
  Liu L, Bi Y, Zhou M, et al.. Appl ACS. Mater. Interf., 2017, 9(8):7424-7435.
33. [33]
  Mullapudi S S, Zhang J, Lu S, et al.. Appl ACS. Bio. Mater., 2019, 2(9):3763-3773.
34. [34]
  He Z, Sun J.. Bioconjugate Chem., 2018, 29(6):1852-1858.
35. [35]
  Sleep D, Cameron J, Evans L R.. Biochim. Biophys. Acta, 2013, 1830(12):5526-5534.
36. [36]
  Bukrinski J T, Sønderby P, Antunes F, et al.. Biochemistry, 2017, 56(36):4860-4870.
37. [37]
  Shi L, Xu L, Wu C, et al.. Appl ACS. Mater. Interf., 2018, 10(10):8555-8565.
38. [38]
  Hu D, Xu H, Xiao B, et al.. Appl ACS. Mater. Interf., 2018, 10(41):34974-34982.
39. [39]
  Lin T, Zhao P, Jiang Y, et al.. Nano ACS, 2016, 10(11):9999-10012.
40. [40]
  Ai S, He X, Liu B, et al.. Mol. Pharm., 2019, 16(6):2616-2625.
41. [41]
  Razi M A, Wakabayashi R, Goto M, et al.. Langmuir, 2019, 35(7):2610-2618.
42. [42]
  Gad S F, Park J, Park J E, et al.. Mol. Pharm., 2018, 15(11):871-881.
43. [43]
  Gong G, Jiao Y, Pan Q, et al.. Biomater ACS. Sci. Eng., 2019, 5(4):1895-1906.
44. [44]
  Cusack M, Freer A.. Chem. Rev., 2008, 108(11):4433-4454.
45. [45]
  Ai S, He X, Liu B, et al.. Mol. Pharm., 2019, 16(6):2616-2625.
46. [46]
  Tian L, Chen Q, Yi X, et al.. Small, 2017, 13(25):1700640.
47. [47]
  Yang Z, Luo S, Zeng Y, et al.. Appl ACS. Mater. Interf., 2017, 9(8):6839-6848.
48. [48]
  Jiang Y, Stenzel M.. Macromol. Biosci., 2016, 16(6):791-802.
49. [49]
  Saha A, Pradhan N, Chatterjee S, et al.. Appl ACS. Nano Mater., 2019, 2(6):3671-3683.
50. [50]
  Jiang Y, Wong S, Chen F, et al.. Bioconju. Chem., 2017, 28(4):979-985.
51. [51]
  Ke P C, Lin S, Parak W J, et al.. Nano ACS, 2017, 11(12):11773-11776.
52. [52]
  Cao H, Zou L, He B, et al.. Adv. Funct. Mater., 2017, 27(11):1605679.
53. [53]
  Zhang R R, Grudzinksi J J, Mehta T I, et al.. Mol. Pharm., 2019, 16(8):3350-3360.
54. [54]
  Fu Y, Han H H, Zhang J, et al.. J. Am. Chem. Soc., 2018, 140(28):8671-8674.
55. [55]
  Yang Y, Jia T, Xu F, et al.. Appl ACS. Nano Mater., 2018, 1(3):1058-1065.
56. [56]
  Wahsner J, Gale E M, Rodr A, et al.. Chem. Rev., 2019, 119(2):957-1057.
57. [57]
  Zhang Y, Zou T, Guan M, et al.. Appl ACS. Mater. Interf., 2016, 8(18):11246-11254.
58. [58]
  Zhou Z, Bai R, Wang Z, et al.. Bioconju. Chem., 2019, 30(6):1821-1829.
59. [59]
  Kumar A, Kim S, Nam J.. J. Am. Chem. Soc., 2016, 138(44):14509-14525.
60. [60]
  Hasler R, Schibli R, Umbricht C A, et al.. Mol. Pharm., 2018, 15(12):5556-5564.
61. [61]
  Wu C, Hsieh C, Wu Y.. Mol. Pharm., 2011, 8(6):1996-2011.
62. [62]
  Zhang M, Xing L, Ke H, et al.. Appl ACS. Mater. Interf., 2017, 9(13):11337-11344.
63. [63]
  Melamed J R, Edelstein R S, Day E S.. Nano ACS, 2015, 9(1):6-11.
64. [64]
  Lucky S S, Soo K C, Zhang Y.. Chem. Rev., 2015, 115(4):1990-2042.
65. [65]
  Yang G, Zeng S, Phua F, et al.. Adv. Mater., 2019, 31(28):1901513.
66. [66]
  Xu L, Wang S, Xu C, et al.. Appl ACS. Mater. Interf., 2019, 11(42):38385-38394.
67. [67]
  Schmidt T W, Castellano F N.. J. Phys. Chem. Lett., 2014, 5(22):4062-4072.
68. [68]
  Sabri T, Pawelek P D, Capobianco J A.. Appl ACS. Mater. Interf., 2018, 10(32):26947-26953.
69. [69]
  Reinhardt C J.. Biochemistry, 2018, 57(2):194-199.
70. [70]
  Chen Q, Liu X, Zeng J, et al.. Biomaterials, 2016, 98, 23-30.
71. [71]
  Han L, Xia J, Hai X, et al.. Appl ACS. Mater. Interf., 2017, 9(8):6941-6949.
72. [72]
  Hua X, Bao Y, Zeng J, et al.. Appl ACS. Mater. Interf., 2018, 10(49):42077-42087.
73. [73]
  Chen J, Liu L, Motevalli S M, et al.. Adv. Funct. Mater., 2018, 28(17):1707291.
74. [74]
  Zhang Z, Yu P, Gou Y, et al.. J. Med. Chem., 2019, 62(23):10630-10644.
75. [75]
  Wang X, Sheng W, Wang Y, et al.. Mol. Pharm., 2018, 15(6):2403-2412.
76. [76]
  Liu L, Bi Y, Zhou M, et al.. Appl. Mater. Interf., 2017, 9(8):7424-7435.
77. [77]
  Zhang C, Wu J, Liu W, et al.. Appl ACS. Mater. Interf., 2019, 11, 44989-44998.
78. [78]
  Tian L, Chen Q, Yi X, et al.. Small, 2017, 13(25):1700640.
79. [79]
  Chen Q, Feng L, Liu J, et al.. Adv. Mater., 2016, 28(33):7129-7136.
80. [80]
  Yang W, Guo W, Le W, et al.. Nano ACS, 2016, 10(11):10245-10257.
81. [81]
  Ren H, Liu J, Su F, et al.. Appl ACS. Mater. Interf., 2017, 9, 3463-3473.
82. [82]
  Wang X, Gao S, Qin Z, et al.. Appl ACS. Mater. Interf., 2018, 10(17):15140-15149.
1. [1]
  Ping Song , Nan Zhang , Jie Wang , Rui Yan , Zhiqiang Wang , Yingxue Jin . Experimental Teaching Design on Synthesis and Antitumor Activity Study of Cu-Pyropheophorbide-a Methyl Ester. University Chemistry, 2024, 39(6): 278-286. doi: 10.3866/PKU.DXHX202310087
2. [2]
  Hanxue LIU , Shijie LI , Meng REN , Xuling XUE , Hongke LIU . Design and antitumor properties of dehydroabietic acid functionalized cyclometalated iridium(Ⅲ) complex. Chinese Journal of Inorganic Chemistry, 2025, 41(8): 1483-1494. doi: 10.11862/CJIC.20250031
3. [3]
  Xiaotong LU , Pan ZHANG , Zijie ZHAO , Lei HUANG , Hongwei ZUO , Lili LIANG . Antitumor and antibacterial activities of pyridyl Schiff base indium and dysprosium complexes. Chinese Journal of Inorganic Chemistry, 2025, 41(8): 1523-1532. doi: 10.11862/CJIC.20250073
4. [4]
  Jiahao Zeng , Hui Chao . 诱导程序性细胞死亡的金属抗肿瘤药物研究. University Chemistry, 2025, 40(6): 145-159. doi: 10.12461/PKU.DXHX202406019
5. [5]
  Peng YUE , Liyao SHI , Jinglei CUI , Huirong ZHANG , Yanxia GUO . Effects of Ce and Mn promoters on the selective oxidation of ammonia over V₂O₅/TiO₂ catalyst. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 293-307. doi: 10.11862/CJIC.20240210
6. [6]
  Fa Wang , Yu Chen , Hui Chao . Ruthenium(II) Complexes as Photoactivated Chemo-Prodrugs for Hypoxic Tumor Therapy. University Chemistry, 2025, 40(7): 200-212. doi: 10.12461/PKU.DXHX202410024
7. [7]
  Aiai WANG , Lu ZHAO , Yunfeng BAI , Feng FENG . Research progress of bimetallic organic framework in tumor diagnosis and treatment. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1825-1839. doi: 10.11862/CJIC.20240225
8. [8]
  Jian Li , Yu Zhang , Rongrong Yan , Kaiyuan Sun , Xiaoqing Liu , Zishang Liang , Yinan Jiao , Hui Bu , Xin Chen , Jinjin Zhao , Jianlin Shi . Highly Efficient, Targeted, and Traceable Perovskite Nanocrystals for Photoelectrocatalytic Oncotherapy. Acta Physico-Chimica Sinica, 2025, 41(5): 100042-0. doi: 10.1016/j.actphy.2024.100042
9. [9]
  Jing WU , Puzhen HUI , Huilin ZHENG , Pingchuan YUAN , Chunfei WANG , Hui WANG , Xiaoxia GU . Synthesis, crystal structures, and antitumor activities of transition metal complexes incorporating a naphthol-aldehyde Schiff base ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2422-2428. doi: 10.11862/CJIC.20240278
10. [10]
  Ruiqing LIU , Wenxiu LIU , Kun XIE , Yiran LIU , Hui CHENG , Xiaoyu WANG , Chenxu TIAN , Xiujing LIN , Xiaomiao FENG . Three-dimensional porous titanium nitride as a highly efficient sulfur host. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 867-876. doi: 10.11862/CJIC.20230441
11. [11]
  Xuejie Wang , Guoqing Cui , Congkai Wang , Yang Yang , Guiyuan Jiang , Chunming Xu . Research Progress on Carbon-based Catalysts for Catalytic Dehydrogenation of Liquid Organic Hydrogen Carriers. Acta Physico-Chimica Sinica, 2025, 41(5): 100044-0. doi: 10.1016/j.actphy.2024.100044
12. [12]
  Qi Wang , Yicong Gao , Feng Lu , Quli Fan . Preparation and Performance Characterization of the Second Near-Infrared Phototheranostic Probe: A New Design and Teaching Practice of Polymer Chemistry Comprehensive Experiment. University Chemistry, 2024, 39(11): 342-349. doi: 10.12461/PKU.DXHX202404141
13. [13]
  Xinghai Liu , Hongke Wu . Exploration and Practice of Ideological and Political Education in Heterocyclic Chemistry Based on "Fentanyl" Event. University Chemistry, 2024, 39(8): 359-364. doi: 10.3866/PKU.DXHX202312100
14. [14]
  Xiaoxuan Yu , Wukun Liu . Practice of Ideological and Political Education in Medicinal Chemistry for Pharmacy Administration Major: A Case Study on the Discovery of Cisplatin’s Anticancer Function. University Chemistry, 2025, 40(4): 408-414. doi: 10.12461/PKU.DXHX202405200
15. [15]
  Hailian Tang , Siyuan Chen , Qiaoyun Liu , Guoyi Bai , Botao Qiao , Liu Fei . Stabilized Rh/hydroxyapatite Catalyst for Furfuryl Alcohol Hydrogenation: Application of Oxidative Strong Metal-Support Interactions in Reducing Conditions. Acta Physico-Chimica Sinica, 2025, 41(4): 2408004-0. doi: 10.3866/PKU.WHXB202408004
16. [16]
  Tingting XU , Wenjing ZHANG , Yongbo SONG . Research advances of atomic precision coinage metal nanoclusters in tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2275-2285. doi: 10.11862/CJIC.20240229
17. [17]
  Xue Wu , Yupeng Liu , Bingzhe Wang , Lingyun Li , Zhenjian Li , Qingcheng Wang , Quansheng Cheng , Guichuan Xing , Songnan Qu . Rationally assembling different surface functionalized carbon dots for enhanced near-infrared tumor photothermal therapy. Acta Physico-Chimica Sinica, 2025, 41(9): 100109-0. doi: 10.1016/j.actphy.2025.100109
18. [18]
  Jiahui CHEN , Tingting ZHENG , Xiuyun ZHANG , Wei LÜ . Research progress of near-infrared absorption inorganic nanomaterials in photothermal and photodynamic therapy of tumors. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2396-2414. doi: 10.11862/CJIC.20240106
19. [19]
  Yongjie ZHANG , Bintong HUANG , Yueming ZHAI . Research progress of formation mechanism and characterization techniques of protein corona on the surface of nanoparticles. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2318-2334. doi: 10.11862/CJIC.20240247
20. [20]
  Xinran Zhang , Siqi Liu , Yichi Chen , Qingli Zou , Qinghong Xu , Yaqin Huang . From Protein to Energy Storage Materials: Edible Gelatin Jelly Electrolyte. University Chemistry, 2025, 40(7): 255-266. doi: 10.12461/PKU.DXHX202408104

Get Citation

PDF

XML

Metrics

PDF Downloads(180)
Abstract views(6602)
HTML views(2593)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142