Home

Citation: Tian Zhenfen, Lv Wenhua, Gong Yabin, Zhang Zhaoyue, Chen Yunqi, Zou Aihua. Preparation and Characterization of Bufalin Nanostructure Lipid Carrier[J]. Chemistry, ;2017, 80(7): 679-683. shu

Preparation and Characterization of Bufalin Nanostructure Lipid Carrier

1.
School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237
2.
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, 200437
3.
International College of Engineering, East China University of Science and Technology, Shanghai 200237

Corresponding author: Zou Aihua, aihuazou@ecust.edu.cn
Received Date: 10 January 2017
Accepted Date: 3 March 2017

Figures(3)

In this paper, Bufalin loaded nanostructure lipid carrier (BUF-NLC) was successfully prepared by high pressure homogenization. The physicochemical properties, in vitro release and cytotoxicity (MTT) were characterized. The results indicated that BUF-NLC has small particle size, good dispersibility and stability. The MTT test suggested that the cytotoxicity of BUF-NLC on tumor cells was lower than free BUF in the initial stage, but after prolonged the action time, the cytotoxicity of BUF-NLC was consistent with that of BUF, indicating that NLC package does not reduce the cytotoxicity of BUF, but gradually release it, which was very important to overcome the side-effects caused by the high toxicity of BUF.
- Bufalin (BUF),
- Nanostructure lipid carrier (NLC),
- Sustained release,
- Toxicity
1. [1]
2. [2]
  Y Li, H Zhao, L R Duanet al. Colloid. Surf. A, 2014, 444:54~62.
3. [3]
  Y Liu, P Wang, C Su et al. Int. J. Pharm., 2010, 397(1/2):155~163.
4. [4]
  P Yin, Y Wang, Y Qiu et al. Int. J. Nanomed., 2012, 7(2):3961~3969.
5. [5]
  X Tian, H Z Yin, S C Zhang et al. Eur. J. Pharm. Biopharm.,2014, 87:445~453.
6. [6]
  J Varshosaz, S Eskandari, M Tabakhian. Pharm. Dev. Technol., 2010, 15(1):89~96.
7. [7]
  M L Bondì, E F Craparo, G Giammona. Drug Deliv., 2007, 14(2):61~67.
8. [8]
  S Anne, K C Gordon, R Thomas. Int. J. Pharm., 2006, 314(1):56~62.
9. [9]
  P Lakshmi, G A Kumar. Int. J. Pharm. Pharm. Sci., 2010, 2(4):35~40.
10. [10]
  E B Souto, R H Müller. Handb. Exp. Pharmacol., 2011, 197:115~141.
11. [11]
  Y Y Chen, X M Yang, L Zhao et al. Colloid. Surf. A, 2014, 455(1):36~43.
12. [12]
  T L Zong, L Mei, H L Gao et al. Mol. Pharm., 2014, 11(7):2346~2357.
13. [13]
  K Hayashi, T Tatsui, T Shimanouchi et al. Int. J. Biol. Sci., 2013, 9(2):142~148.
14. [14]
  D R Kalaria, G Sharma, V Beniwal et al. Pharm. Res., 2009, 26:492~501.
15. [15]
  J E Kim, I S Yoon, H J Cho et al. Int. J. Pharm. Pharm. Sci., 2014,464(1/2):117~126.
1. [1]
  Tianyang Yu , Hao Wei . “Illness Enters through the Mouth”: A Brief Overview of Toxic Chemical Substances in Common Foods. University Chemistry, 2025, 40(7): 225-231. doi: 10.12461/PKU.DXHX202409083
2. [2]
  Gaofeng Zeng , Shuyu Liu , Manle Jiang , Yu Wang , Ping Xu , Lei Wang . Micro/Nanorobots for Pollution Detection and Toxic Removal. University Chemistry, 2024, 39(9): 229-234. doi: 10.12461/PKU.DXHX202311055
3. [3]
  Hanmei Lü , Xin Chen , Qifu Sun , Ning Zhao , Xiangxin Guo . Uniform Garnet Nanoparticle Dispersion in Composite Polymer Electrolytes. Acta Physico-Chimica Sinica, 2024, 40(3): 2305016-0. doi: 10.3866/PKU.WHXB202305016
4. [4]
  Peng ZHOU , Xiao CAI , Qingxiang MA , Xu LIU . Effects of Cu doping on the structure and optical properties of Au₁₁(dppf)₄Cl₂ nanocluster. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1254-1260. doi: 10.11862/CJIC.20240047
5. [5]
  Qi Li , Pingan Li , Zetong Liu , Jiahui Zhang , Hao Zhang , Weilai Yu , Xianluo Hu . Fabricating Micro/Nanostructured Separators and Electrode Materials by Coaxial Electrospinning for Lithium-Ion Batteries: From Fundamentals to Applications. Acta Physico-Chimica Sinica, 2024, 40(10): 2311030-0. doi: 10.3866/PKU.WHXB202311030
6. [6]
  Liang MA , Honghua ZHANG , Weilu ZHENG , Aoqi YOU , Zhiyong OUYANG , Junjiang CAO . Construction of highly ordered ZIF-8/Au nanocomposite structure arrays and application of surface-enhanced Raman spectroscopy. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1743-1754. doi: 10.11862/CJIC.20240075
7. [7]
  Yinyin Qian , Rui Xu . Utilizing VESTA Software in the Context of Material Chemistry: Analyzing Twin Crystal Nanostructures in Indium Antimonide. University Chemistry, 2024, 39(3): 103-107. doi: 10.3866/PKU.DXHX202307051
8. [8]
  Chen Pu , Daijie Deng , Henan Li , Li Xu . Fe_0.64Ni_0.36@Fe₃NiN Core-Shell Nanostructure Encapsulated in N-Doped Carbon Nanotubes for Rechargeable Zinc-Air Batteries with Ultralong Cycle Stability. Acta Physico-Chimica Sinica, 2024, 40(2): 2304021-0. doi: 10.3866/PKU.WHXB202304021
9. [9]
  Ruiqing LIU , Wenxiu LIU , Kun XIE , Yiran LIU , Hui CHENG , Xiaoyu WANG , Chenxu TIAN , Xiujing LIN , Xiaomiao FENG . Three-dimensional porous titanium nitride as a highly efficient sulfur host. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 867-876. doi: 10.11862/CJIC.20230441
10. [10]
  Xuejie Wang , Guoqing Cui , Congkai Wang , Yang Yang , Guiyuan Jiang , Chunming Xu . Research Progress on Carbon-based Catalysts for Catalytic Dehydrogenation of Liquid Organic Hydrogen Carriers. Acta Physico-Chimica Sinica, 2025, 41(5): 100044-0. doi: 10.1016/j.actphy.2024.100044
11. [11]
  Xinghai Liu , Hongke Wu . Exploration and Practice of Ideological and Political Education in Heterocyclic Chemistry Based on "Fentanyl" Event. University Chemistry, 2024, 39(8): 359-364. doi: 10.3866/PKU.DXHX202312100
12. [12]
  Xianyong Lu , Tao Hu . Developing an Innovative Inorganic Chemistry Teaching Model Based on Aerospace Specialty Characteristics. University Chemistry, 2025, 40(7): 127-131. doi: 10.12461/PKU.DXHX202409037
13. [13]
  Xinran Zhang , Siqi Liu , Yichi Chen , Qingli Zou , Qinghong Xu , Yaqin Huang . From Protein to Energy Storage Materials: Edible Gelatin Jelly Electrolyte. University Chemistry, 2025, 40(7): 255-266. doi: 10.12461/PKU.DXHX202408104
14. [14]
  Jiandong Liu , Zhijia Zhang , Kamenskii Mikhail , Volkov Filipp , Eliseeva Svetlana , Jianmin Ma . Research Progress on Cathode Electrolyte Interphase in High-Voltage Lithium Batteries. Acta Physico-Chimica Sinica, 2025, 41(2): 2308048-0. doi: 10.3866/PKU.WHXB202308048
15. [15]
  Xiaoxuan Yu , Wukun Liu . Practice of Ideological and Political Education in Medicinal Chemistry for Pharmacy Administration Major: A Case Study on the Discovery of Cisplatin’s Anticancer Function. University Chemistry, 2025, 40(4): 408-414. doi: 10.12461/PKU.DXHX202405200
16. [16]
  Zhaoxuan ZHU , Lixin WANG , Xiaoning TANG , Long LI , Yan SHI , Jiaojing SHAO . Application of poly(vinyl alcohol) conductive hydrogel electrolytes in zinc ion batteries. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 893-902. doi: 10.11862/CJIC.20240368
17. [17]
  Changsheng An , Tao Liu . Decoding SEI chemistry at the lithium-metal potential. Acta Physico-Chimica Sinica, 2025, 41(9): 100101-0. doi: 10.1016/j.actphy.2025.100101
18. [18]
  Zhi Dou , Huiyu Duan , Yixi Lin , Yinghui Xia , Mingbo Zheng , Zhenming Xu . High-Throughput Screening Lithium Alloy Phases and Investigation of Ion Transport for Solid Electrolyte Interphase Layer. Acta Physico-Chimica Sinica, 2024, 40(3): 2305039-0. doi: 10.3866/PKU.WHXB202305039
19. [19]
  Ke Qiu , Fengmei Wang , Mochou Liao , Kerun Zhu , Jiawei Chen , Wei Zhang , Yongyao Xia , Xiaoli Dong , Fei Wang . A Fumed SiO₂-based Composite Hydrogel Polymer Electrolyte for Near-Neutral Zinc-Air Batteries. Acta Physico-Chimica Sinica, 2024, 40(3): 2304036-0. doi: 10.3866/PKU.WHXB202304036
20. [20]
  Fangxuan Liu , Ziyan Liu , Guowei Zhou , Tingting Gao , Wenyu Liu , Bin Sun . 中空结构光催化剂. Acta Physico-Chimica Sinica, 2025, 41(7): 100071-0. doi: 10.1016/j.actphy.2025.100071

Get Citation

PDF

XML

Metrics

PDF Downloads(3)
Abstract views(665)
HTML views(174)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return