Citation: Guo Ping WANG, Li Cheng YAN, Long Guan ZHU. Synthesis, Crystal Structure and Antitumor Activity of Mixed Ligand Coordination Compound of Copper with Norfloxacin and 1, 10-Phen,[Cu (NFLX)(phen)(H₂O)] NO₃ ·3H₂O[J]. Chinese Chemical Letters, ;2003, 14(11): 1182-1184. shu

Synthesis, Crystal Structure and Antitumor Activity of Mixed Ligand Coordination Compound of Copper with Norfloxacin and 1, 10-Phen,[Cu (NFLX)(phen)(H₂O)] NO₃ ·3H₂O

1.
Department of Chemistry, Zhejiang University, Hangzhou 310027;
2.
Department of Chemistry, Hangzhou Teachers College, Hangzhou 310012

Received Date: 17 March 2003

Fund Project: This work was funded by the National Natural Science Foundation of China (No. 50073019). Antibacterial test was performed by the National Center for Drug Screening of China.

The mixed ligand coordination compound of copper with norfloxacin (NFLX) and 1, 10-phen has been synthesized and characterized by means of X-ray single crystal diffraction. The structure features of the coordination compound are described. Antibacterial activities of the coordination compound have been tested against different microorganisms. The antitumor activities of the coordination compound on leukemia HL-60 cell line and liver cancer BEL-7402 cell line have been measured, respectively. The results indicated that the coordination compound has strong inhibitory effect on HL-60 and BEL-7402 cell lines.
- Synthesis,
- crystal structure,
- antitumor activity,
- norfloxacin,
- coordination compound of copper
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