Citation: Chun YANG, Wen Yi HE, Li Jun LI, Rui Ming XU, Shou Ren ZHANG, Zeper ABLIZ, Yi Kang SI. Using Nuclear Magnetic Resonance and MS/MS Spectroscopy for the Identification of Brodimoprim Metabolites in Rat Urine[J]. Chinese Chemical Letters, ;2001, 12(6): 513-516. shu

Using Nuclear Magnetic Resonance and MS/MS Spectroscopy for the Identification of Brodimoprim Metabolites in Rat Urine

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050

Received Date: 18 September 2000

Eight metabolites of brodimoprim (BDP) in rat urine were detected by NMR and ESI-MS/MS. They were demethyl-BDP glucuronide, demethyl-BDP sulfurate, demethyl-BDP glucuronide sulfurate, α-hydroxyl-BDP, α-hydroxyl-BDP glucuronide, BDP sulfurate, N-oxide-BDP sulfurate, and α-hydroxyl-N-oxide-BDP sulfurate. All the sulfurates are reported for the first time.
- Nuclear magnetic resonance spectroscopy,
- MS/MS spectroscopy,
- metabolites,
- brodimoprim.
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