Citation: Wang Yiying, Dong Yuman, Yin Wei, Liu Huanyu, Meng Tao. Progress in the Process Intensification of Whole-Cell Biocatalysis[J]. Chemistry, ;2020, 83(10): 875-882. shu

Progress in the Process Intensification of Whole-Cell Biocatalysis

School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031

Corresponding author: Meng Tao, taomeng@swjtu.edu.cn
Received Date: 21 May 2020
Accepted Date: 12 June 2020

Figures(5)

Cells are the main tool in whole cell biocatalysis. Cell membranes has the disadvantage of resistance to mass transfer, so the efficiency of cell catalysis is much lower than that of free enzyme catalysis. Improving mass transfer to intensify the reaction process is a key issue to be solved in whole cell biocatalysis. Herein, we summarize recent progresses in this field from the perspective of process intensification, which includes improving cell membrane permeability and using microfluidic tools. Moreover, the mechanisms and characteristics of these methods are analyzed. In addition, the challenges and perspectives for further advancing whole cell biocatalysis process intensification are proposed, which provides a reference for the development in this field.
- Cell catalysis,
- Mass transfer,
- Microscale,
- Process intensification,
- Membranes
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