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Citation: Chen Hansong, Li Zhengming. Synthesis and Biological Activities of 3-Pyrazolyl-6-substituted-s-triazolo [3,4-b]-1,3,4-thiadiazoles[J]. Chinese Journal of Applied Chemistry, ;1998, 15(3): 59-62. shu

Synthesis and Biological Activities of 3-Pyrazolyl-6-substituted-s-triazolo [3,4-b]-1,3,4-thiadiazoles

Institute of Elemento Organic Chemistry, Nankai University, Tianjin 300071

Received Date: 21 October 1997
Revised Date: 16 March 1998

In view of the biological activity of s-triazolo [3,4-b]-1,3,4-thiadiazole fused heterocyclic derivatives, nine novel compounds 3-((4'-chloro)-3'-ethyl-1'-methyl-5'-pyrazolyl)-6-substituted-s-triazolo [3,4-b]-1,3,4-thiadiazoles (4a~g,5,6) were synthesized by condensation of carboxylic acid with 4-amino-3-((4'-chloro)-3'-ethyl-1'-methyl-5'-pyrazolyl)-1,2,4-triazole-5-thione. Their structures were characterized by elemental analysis, ¹H NMR, IR and MS spectroscopy. The preliminary bioassay tests showed that compound 3 exhibited plant growth regulation activity and 4b, 4d and 6 possessed moderate fungicidal activity.
- pyrazolyl-s-triazolo [3,4-b]-1,3,4-thiadiazole,
- synthesis,
- bioassay,
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