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Citation: Li Shangfeng, Ma Xiuguang, Huang Yijun. A New Synthetic Protocol for a Series of Novel Homocamptothecin Compounds[J]. Chemistry, ;2017, 80(12): 1148-1151, 1127. shu

A New Synthetic Protocol for a Series of Novel Homocamptothecin Compounds

Sundia MediTech Co., Ltd., Shanghai 201203

Received Date: 25 May 2017
Accepted Date: 12 September 2017

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A new strategy was developed to synthesize a series of homocamptothecin compounds starting from t-butyl bromoacetate. This way is quite straightforward and simple and the gross yield makes a great improvement without the use of the reported phosphate or other traditional protecting groups. It enhances the solubility of each camptothecin derivative, accelerates the reaction to completion and simplifies the workup and purification procedures. As a result, a lot of amides could be obtained conveniently.
- Homocamptothecin,
- topoisomerase
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