Citation: Shao Lihui, Gan Yiyuan, Zhang Liqiong, Wang Zhenchao, Ouyang Guiping. Progress in Syntheses and Antitumor Activities of 6-Substituted Quinazoline Derivatives[J]. Chemistry, ;2019, 82(9): 779-788. shu

Progress in Syntheses and Antitumor Activities of 6-Substituted Quinazoline Derivatives

Shao Lihui ^1,2 ,
Gan Yiyuan ^1,2 ,
Zhang Liqiong ^1,2 ,
Wang Zhenchao ^1,2,3,, ,
Ouyang Guiping ^1,2,3,4,,

1.
School of Pharmacy, Guizhou University, Guiyang 550025
2.
State Key Laboratory of Functions and Applications of Medicinal Plants, Guiyang 550014
3.
Guizhou Synthetic Drug Engineering Laboratory, Guiyang 550025
4.
Fine Chemical Research and Development Center, Guizhou University, Guiyang 550025

Corresponding author: Wang Zhenchao, wzc.4884@163.com Ouyang Guiping, oygp710@163.com
Received Date: 29 May 2019
Accepted Date: 25 June 2019

Figures(1)

Quinazoline and its derivatives, as an important pharmacophore, have a broad spectrum of antitumor biological activity, and have been the focus of medicinal chemistry research. In this paper, the syntheses of quinazoline derivatives with different substituents such as amides, halogens, ethers, 7-rings, heterocyclics derivatives, as well as their antitumor biological activity were reviewed. It is expected to provide a reference for the desigs and syntheses of new anticancer compounds with higher activity and less toxicity.
- 6-Substituted quinazoline,
- Antitumor activity,
- Tyrosine kinase inhibitor,
- Mechanism of action
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