Citation: Zhao Bo, Zhao Renjie, Zhu Hong. Syntheses, Characterizations and Bioassay of Imidazo[1, 5-a] Pyridinium Salts[J]. Chemistry, ;2020, 83(1): 70-74. shu

Syntheses, Characterizations and Bioassay of Imidazo[1, 5-a] Pyridinium Salts

Zhao Bo ¹ ,
Zhao Renjie ² ,
Zhu Hong ^1,,

1.
School of Basic Medical Sciences, North Sichuan Medical College, Nanchong, 637000
2.
Department of Psychiatry, North Sichuan Medical College, Nanchong, 637000

Corresponding author: Zhu Hong, zhuhongyuxia@163.com
Received Date: 15 August 2019
Accepted Date: 19 September 2019

Figures(3)

Imidazo[1, 5-a] pyridinium salts were synthesized via a facile three-component coupling reaction. Their structures were confirmed by ¹H NMR, ¹³C NMR, MS and X-ray crystal diffraction analysis. Unexpected structures were obtained using diethylenetriamine and triethylenetetramine as raw materials. The antibacterial properties of the as-synthesized salts were studied by minimal inhibitory concentration (MIC) method using penicillin as a control. The results showed that all the compounds have antibacterial effect on Micrococcus lysococcus and Streptococcus B, and the antibacterial effect of compound 2 was the best. Compound 3 containing heteroatom O has stronger antibacterial activity against Maltophilia maltophilia and Klebsiella pneumoniae than that of penicillin. The biphenyl bridged bidentate imidazole[1, 5-a]pyridinium salt (compound 5) has a better antibacterial effect than the ethyl bridged bidentate imidazole[1, 5-a]pyridinium salt (compound 4). Compound 6 having a monodentate large π system aromatic ring has better antibacterial effect than that of compounds 7 and 8 containing a bidentate large π system aromatic ring.
- Ionic liquid,
- Imidazo[1, 5-a] pyridinium salts,
- Antibacterial activities
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1.
沈阳化工大学材料科学与工程学院沈阳 110142