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Citation: Zhiping Liu, Chunfang Gan, Yanmin Huang, Jianguo Cui, Wanxing Wei. Syntheses and Cytotoxicities of Polyoxime Naringin Derivatives[J]. Chemistry, ;2021, 84(1): 90-95. shu

Syntheses and Cytotoxicities of Polyoxime Naringin Derivatives

1.
College of Chemistry and Material, Nanning Normal University, Nanning, 530001
2.
College of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004

Corresponding author: Zhiping Liu, liuzhiping828@126.com
Received Date: 14 July 2020
Accepted Date: 5 September 2020

Figures(1)

Taking natural product naringenin as raw material, it was etherified with α-bromoacetophenone, 4-chloro-α-bromoacetophenone, 1-(2-bromoethyl)-indole-3-formaldehyde and α-bromoacetone respectively. Then the intermediate products were subjected to oximation reaction with hydroxylamine hydrochloride and methoxyamine hydrochloride to obtained eight polyoxime naringin derivatives 6~13. Their structures were determined by IR, NMR and HR-MS. The cytotoxic activities of the target compounds were evaluated against SGC-7901 by MTT method in vitro. The results showed that the compounds 10 and 12 display distinct antiproliferative activity against SGC-7901 with the values of IC₅₀ 16.4 and 15.3 μmol/L, respectively.
- Naringin,
- Polyoxime,
- Cytotoxicity
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