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Citation: Duan Jianfeng, Mu Xiaojing, Zhou Zhao, Bi Jingfu, Xiao Shangyou. Syntheses of 2, 3-Dihydroquinazolin-4(1H)-ones Derivatives in High Temperature Water[J]. Chemistry, ;2018, 81(11): 1023-1027. shu

Syntheses of 2, 3-Dihydroquinazolin-4(1H)-ones Derivatives in High Temperature Water

School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030

Corresponding author: Xiao Shangyou, xsy6508@163.com
Received Date: 8 June 2018
Accepted Date: 16 August 2018

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In order to develop green chemistry and reduce the amount of toxic solvents in chemical reactions, 2, 3-dihydroquinazoline-4(1H)-one derivatives were synthesized successfully with 2-aminobenzamide and aldehyde as substrates and high temperature water as solvent in the absence of organic solvent and catalyst. The reaction temperature, reaction time and the effect of substituents on the aromatic ring on the reaction were investigated. Under the optimal conditions of molar ratio 1:1, temperature of 130℃ and reaction time of 1 h, the yield was 32.4%~85.7%.
- High-temperature water,
- 2-Aminophenamide,
- Aldehydes,
- 2, 3-Dihydroquinazolin-4(1H)-one derivatives,
- Green chemistry
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