Citation: Ding Shenglong, Cong Yun, Gao Chunmai, Liu Mingzhu. Application Development in Estimation of Molecular Weight by Gel Permeation Chromatography[J]. Chemistry, ;2017, 80(2): 151-156. shu

Application Development in Estimation of Molecular Weight by Gel Permeation Chromatography

College of Chemistry and Engineering, Lanzhou University, Lanzhou 730000

Corresponding author: Liu Mingzhu, mzliu@lzu.edu.cn
Received Date: 26 July 2016
Accepted Date: 10 September 2016

Figures(1)

The application and development of molecular weight estimation for oils-soluble and water-soluble polymers by gel permeation chromatography (GPC) is summarized. The effects of pH, salt concentration and temperature on molecular weight estimation of water-soluble ones are presented. In addition, novel utilizations of GPC with dual detectors are introduced. Calibration methodologies in GPC, including various instrumental method and director calibration, as well as universal calibration are reviewed. With the combination of multi-detectors, the performance of one detector could be effectively checked against others and the estimated molecular weights of polymer tend to be reliable and precise.
- Gel permeation chromatography,
- Molecular weight,
- No-size exclusion effect,
- Water soluble polymer
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