Citation: Zhang Aiqin, Wang Man, Zhang Hui, Jin Jun, Shen Gangyi. Advances in Label-Free Optical Biosensor[J]. Chemistry, ;2018, 81(1): 21-28, 44. shu

Advances in Label-Free Optical Biosensor

Zhang Aiqin ¹ ,
Wang Man ² ,
Zhang Hui ¹ ,
Jin Jun ^1,, ,
Shen Gangyi ^2,,

1.
College of Life and Environmental Science, Beijing Engineering Research Center of Food Environment and Public Health, Minzu University of China, Beijing 100081
2.
College of Pharmacy, Key Laboratory of Ethnomedicine, Ministry of Education, Minzu University of China, Beijing 100081

Corresponding author: Jin Jun, junjin3799@126.com; Shen Gangyi, shengy@muc.edu.cn
Received Date: 6 July 2017
Accepted Date: 8 October 2017

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Label-free optical biosensor has been widely studied and applied to the research fields including chemistry, pharmacy and biology associated with life science recently, due to its key features such as label-free of target molecule, dynamic monitoring, non-destructive detection and so on. This article mainly focuses on the current development of four representative kinds of label-free optical biosensors, including surface plasmon resonance biosensor, optical waveguide light mode spectroscopy biosensor, spectroscopic ellipsometry biosensor, and reflectometry interference spectroscopy biosensor. In addition to the introduction of the instrument structure and mechanism, method development, and applications in various fields, the advantages and shortcomings of these methods are discussed, which may illuminate the future development.
- Optical biosensor,
- Label-free,
- Surface plasmon resonance,
- Optical waveguide lightmode spectroscopy,
- Spectroscopic ellipsometry,
- Reflectometry interference spectroscopy
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