Citation: Wang Min, Pan He, Jiang Hongxu, Zhang Shun. One-Pot Synthesis of N1-Substituted 3, 4-Dihydropyrimidin-2(1H)-ones Catalyzed by Stannous Chloride Dihydrate[J]. Chemistry, ;2017, 80(9): 863-867. shu

One-Pot Synthesis of N1-Substituted 3, 4-Dihydropyrimidin-2(1H)-ones Catalyzed by Stannous Chloride Dihydrate

College of Chemistry & Chemical Engineering, Bohai University, Jinzhou 121013

Received Date: 23 February 2017
Accepted Date: 11 May 2017

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N1-Substituted 3, 4-dihydropyrimidin-2(1H)-ones were synthesized by a SnCl₂ catalysed three components one-pot reaction using aromatic aldehydes, ethyl acetoacetate (methyl acetoacetate) and monosubstituted urea as raw materials under solvent-free conditions. Effects of the amount of catalyst and the reaction temperature on the yields of product were studied. The structures of the titled products were characterized by IR, ¹H NMR, ¹³C NMR and elemental analysis. A mechanism to rationalize the reaction was proposed. This synthetic method has the advantages of short reaction time, mild reaction conditions, high yield, high catalytic activity, inexpensive catalyst and environmentally benign etc.
- 3, 4-Dihydropyrimidin-2(1H)-ones,
- Stannous chloride dihydrate,
- One pot synthesis,
- Solvent free
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沈阳化工大学材料科学与工程学院沈阳 110142