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Citation: Yang Zihui, Li Wan, Wang Yuhua, Lu Haixia, Guo Linfeng, Yang Ke. Synthesis, Crystal Structure and Herbicidal Activity of Pyridine Carboxamide Containing Diarylamine Group[J]. Chemistry, ;2020, 83(12): 1127-1132. shu

Synthesis, Crystal Structure and Herbicidal Activity of Pyridine Carboxamide Containing Diarylamine Group

Yang Zihui ^3,‡ ,
Li Wan ^2,‡ ,
Wang Yuhua ⁴ ,
Lu Haixia ⁵ ,
Guo Linfeng ⁶ ,
Yang Ke ^1,,

1.
Zhejiang University of Technology, Hangzhou, 310014
2.
College of Pharmaceutical Science, Hebei University, Baoding, 100193
3.
Shan Dong Jinhuahai Biotechnology Co., Ltd., Jinan, 251400
4.
Dezhou Hospital of Traditional Chinese Medicine, Dezhou, 253000
5.
Hangzhou Economic and Technological Development Zone 14 th Street, No.5 Hangzhou, 310018
6.
Building 8, No. 1500 Zuchongzhi Rd., Pudong, Shanghai, 200120

Corresponding author: Yang Ke, yangyongyao168@sina.com
Received Date: 8 April 2020
Accepted Date: 13 June 2020

Figures(4)

The novel compound N-[2-(phenylamino) phenyl]-2-methoxyl pyridine carboxamide (3) was synthesized via three steps, and its structure was characterized by ¹H NMR, ¹³C NMR, ESI-MS and X-ray diffraction. The crystal structure of this compound belongs to monoclinic system, space group P 1 2₁/n 1 with a=10.6329(18), b=13.026(2), c=12.267(2)Å, Z=4, V=12.267(2)Å³, M_r=319.35, D_c=1.270mg/m³, S=1.027, F(000)=672, μ (Mo Kα)=0.085 mm^-1. X-ray crystal structure indicated the presence of intermolecular N(3)-H(3)…O(2) hydrogen bond in the molecule, which plays an important role in stabilizing the crystal structure. The preliminary herbicidal activity bioassay showed that the titled compound 3 had 91.81% inhibition against Barnyard grass at 3000 g a.i/hm².
- Pyridine carboxamide,
- Crystal structure,
- Herbicidal activity,
- Barnyard grass
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