Citation: Wang Yongsheng, Zhao Ling, Wang Tao, Liu Rong. Progress in the Synthesis of (R)-3-Amino-1-butanol[J]. Chemistry, ;2018, 81(11): 986-991. shu

Progress in the Synthesis of (R)-3-Amino-1-butanol

Wang Yongsheng ^1,2, ,
Zhao Ling ³ ,
Wang Tao ^1,2 ,
Liu Rong ^1,2,,

1.
Gansu Chemical Industry Research Institute Co., Ltd., Lanzhou 730020
2.
Gansu Key Laboratory of Fine Chemicals, Lanzhou 730020
3.
Department of Pathology, Lanzhou University Second Hospital, Lanzhou 730020

Corresponding author: Liu Rong, elitelori@hotmail.com
Received Date: 14 June 2018
Accepted Date: 20 August 2018

As a key intermediate for the synthesis of HIV intergrase inhibitors dolutegravir, the quality and price of (R)-3-amino-1-butanol have a significant impact on the quality and production cost of dolutegravir. In this paper, the synthesis of (R)-3-amino-1-butanol was reviewed from five aspects:chemical resolution, chiral synthesis, chemical induction, preparative chromatograph and enzymatic hydrolysis.
- (R)-3-amino-1-butanol,
- Dolutegravir,
- 4-Hydroxy-2-butanone,
- Transaminas
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沈阳化工大学材料科学与工程学院沈阳 110142